A5055820361- Synthesis and biological activity
- Inflammatory mediators and NSAID effects
- Free Radicals and Antioxidants
- Eicosanoids and Hypertension Pharmacology
- Nanocomposite Films for Food Packaging
- Synthesis and Characterization of Heterocyclic Compounds
- Analytical Methods in Pharmaceuticals
- Synthesis of heterocyclic compounds
- biodegradable polymer synthesis and properties
- Biochemical Acid Research Studies
- Computational Drug Discovery Methods
- Synthesis and Reactions of Organic Compounds
- Diabetes Management and Research
- Heart Failure Treatment and Management
- Carbon dioxide utilization in catalysis
- Bone Tissue Engineering Materials
- Analytical Chemistry and Sensors
- Bioactive Compounds and Antitumor Agents
- Antimicrobial agents and applications
- Diabetes and associated disorders
- Cardiac electrophysiology and arrhythmias
- Natural Antidiabetic Agents Studies
- Synthesis and bioactivity of alkaloids
- Electrospun Nanofibers in Biomedical Applications
- Enzyme function and inhibition
Grigore T. Popa University of Medicine and Pharmacy
2013-2021
Alexandru Ioan Cuza University
2019
The xanthine structure has proved to be an important scaffold in the process of developing a wide variety biologically active molecules such as bronchodilator, hypoglycemiant, anticancer and anti-inflammatory agents. It is known that hyperglycemia generates reactive oxygen species which are involved progression diabetes mellitus its complications. Therefore, development new compounds with antioxidant activity could therapeutic strategy against this metabolic syndrome. New thiazolidine-4-one...
Abstract Background Aryl-propionic acid derivatives with ibuprofen as representative drug are very important for therapy, being recommended especially anti-inflammatory and analgesic effects. On other hand 1,3-thiazolidine-4-one scaffold is an heterocycle, which associated different biological effects such analgesic, antioxidant, antiviral, antiproliferative, antimicrobial etc. The present study aimed to evaluated the toxicity degree of new ibuprofen. Methods For evaluation degree, cell...
l-Arginine is a semi-essential aminoacid with important role in regulation of physiological processes humans. It serves as precursor for the synthesis proteins and also substrate different enzymes such nitric oxide synthase. This amino-acid act free radical scavenger, inhibits activity pro-oxidant thus acts an antioxidant has bactericidal effect against broad spectrum bacteria.New thiazolidine-4-one derivatives nitro-l-arginine methyl ester (NO2-Arg-OMe) have been synthesized biologically...
In the past many research studies have focused on thiazolidine-4-one scaffold, due to important biological effects associated with its heterocycle. This scaffold is present in structure of synthetic compounds, which showed significant such as antimicrobial, antifungal, antioxidant, anti-inflammatory, analgesic, antidiabetic effects. It was also identified natural actithiazic acid, isolated from Streptomyces strains. Starting this new xanthine derivatives been synthetized and evaluated for...
Starting from indomethacin (IND), one of the most prescribed non-steroidal anti-inflammatory drugs (NSAIDs), new nitric oxide-releasing derivatives with 1,3,4-oxadiazole-2-thiol scaffold (NO-IND-OXDs, 8a-p) have been developed as a safer and more efficient multitarget therapeutic strategy. The successful synthesis designed compounds (intermediaries finals) was proved by complete spectroscopic analyses. In order to study in silico interaction NO-IND-OXDs cyclooxygenase isoenzymes, molecular...
This work reports the design of [1,3,4]thiadiazolo[3′,2′:1,2]imidazo[4,5-c]quinolines using a Pictet–Spengler reaction. The scope reaction was achieved from 6-(2-aminophenyl)imidazo[2,1-b][1,3,4]thiadiazole derivatives and available aldehydes. A wide range aldehydes were employed to examine cyclization. In parallel, mechanism investigation realized showed hydride transfer which led dismutation intermediate species. To complete this methodological study, "sequential" oxidation/SNAr procedure...
A series of diclofenac hydrazones was synthesized and the structure compounds proved using different spectral methods such as infrared (IR), nuclear magnetic resonance ( 1 H-NMR) high resolution mass spectroscopy (HR-MS).The biological evaluation, focused on in vitro antioxidant effects DPPH (2,2-diphenyl-1-picrylhydrazyl) ABTS (2,2'azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid)) free radicals scavenging assays also performed.An improved effect compared to observed. RezumatO serie de...
The aim of the study was to optimize synthesis diclofenac derivative with hydrazones structure in order obtain higher yields and purity by variation different parameters such as: ratio between reactants, solvent, catalyst, temperature, time reaction method used. anti-inflammatory effects derivatives were evaluated using vitro assays: albumin denaturation erythrocyte membrane stability. obtained results showed that effect tested is increasing concentration, best being at concentration 125...
Glibenclamide and lipoic acid are two drugs frequently recommended for the management of diabetes mellitus, so, development a new formulation containing both substances has great benefit in terms efficiency compliance, acting also as multi-target drug system. Accordingly, aim this study was physicochemicalcharacterization polymeric systems based on chitosan (CS) whose matrix were encapsulated glibenclamide (Gly) (LA). The prepared microparticles (CS–Gly, CS–LA, CS–Gly–LA) through ionic...
The aim of this study was to optimize the method used for obtaining microparticles based on chitosan � a biocompatible, biodegradable, and nontoxic polymer, characterize developed systems. Chitosan microparticles, as drug delivery systems were obtained by inotropic gelation using pentasodiumtripolyphosphate (TPP) cross-linking agent. with low molecular weight (CSLMW) in concentration which ranged between 0.5 5 %, while agent 1 5%. characterization terms shape, uniformity adhesion performed...
Abstract Background Aryl-propionic acid derivatives with ibuprofen as representative drug are very important for therapy, being recommended especially anti-inflammatory and analgesic effects. On other hand 1,3-thiazolidine-4-one scaffold is an heterocycle, which associated different biological effects such analgesic, antioxidant, antiviral, antiproliferative, antimicrobial etc. The present study aimed to evaluated the toxicity degree of new ibuprofen. Methods For evaluation degree, cell...