A5051600468- Synthesis and biological activity
- Nanocomposite Films for Food Packaging
- Advanced Drug Delivery Systems
- Natural Antidiabetic Agents Studies
- Computational Drug Discovery Methods
- Electrospun Nanofibers in Biomedical Applications
- Analytical Methods in Pharmaceuticals
- Antimicrobial agents and applications
- Nanoparticle-Based Drug Delivery
- Synthesis and Characterization of Heterocyclic Compounds
- Diabetes Treatment and Management
- Free Radicals and Antioxidants
- biodegradable polymer synthesis and properties
- Silk-based biomaterials and applications
- Analytical Chemistry and Chromatography
- Wound Healing and Treatments
- Biochemical Acid Research Studies
- Synthesis and Reactions of Organic Compounds
- Enzyme function and inhibition
- Multicomponent Synthesis of Heterocycles
- Synthesis of β-Lactam Compounds
- Plant tissue culture and regeneration
- Biochemical effects in animals
- Fungal Plant Pathogen Control
- Helicobacter pylori-related gastroenterology studies
Grigore T. Popa University of Medicine and Pharmacy
2015-2024
Wound management represents a continuous challenge for health systems worldwide, considering the growing incidence of wound-related comorbidities, such as diabetes, high blood pressure, obesity, and autoimmune diseases. In this context, hydrogels are considered viable options since they mimic skin structure promote autolysis growth factor synthesis. Unfortunately, associated with several drawbacks, low mechanical strength potential toxicity byproducts released after crosslinking reactions....
New series of N-(arylidene)hydrazinoacetyl sulfonamides 4a1–6, 4b1–6 and N-(4-aryl-3-chloro-2-oxoazetidin-1-yl)aminoacetyl 5a1–6, 5b1–6 were synthesized. The structures the new derivatives was confirmed using spectral methods (FT-IR, 1H-NMR, 13C-NMR). antibacterial activities these compounds against Gram positive (Staphyloccoccus aureus ATCC 6583, Staphyloccoccus epidermidis 12228, Enterococcus faecalis 25912) negative (Klebsiella pneumoniae CIP 53153, Proteus vulgaris 104989, Citrobacter...
Type 2 diabetes mellitus (T2DM) is one of the most common metabolic disorders, with a major involvement oxidative stress in its onset and progression. Pioglitazone (Pio) an antidiabetic drug that mainly works by reducing insulin resistance, while curcumin (Cur) powerful antioxidant important hypoglycemic effect. Both drugs are associated several drawbacks, such as reduced bioavailability short half-life time (Pio), well instability poor water solubility (Cur), which limit their therapeutic...
Starting from theophylline (1,3-dimethylxanthine) new thiazolidin-4-one derivatives 7a1–7, 7b1–7 have been synthesized as potential antidiabetic drugs. The structure of the was confirmed using spectral methods (FT-IR, 1H-NMR, 13C-NMR). in vitro antioxidant compounds evaluated according to ferric reducing power, total activity and DPPH ABTS radical scavenging assays. Reactive oxygen species (ROS) free radicals are considered be implicated a variety pathological events, such diabetes mellitus...
The objective of this study was to develop new films based on chitosan functionalized with sulfonamide drugs (sulfametoxydiazine, sulfadiazine, sulfadimetho-xine, sulfamethoxazol, sulfamerazine, sulfizoxazol) in order enhance the biological effects chitosan. morphology and physical properties as well antioxidant sulfonamide-chitosan derivatives were investigated. chitosan-derivative showed a rough surface hydrophilic properties, which are very important features for their use wound dressing....
The xanthine structure has proved to be an important scaffold in the process of developing a wide variety biologically active molecules such as bronchodilator, hypoglycemiant, anticancer and anti-inflammatory agents. It is known that hyperglycemia generates reactive oxygen species which are involved progression diabetes mellitus its complications. Therefore, development new compounds with antioxidant activity could therapeutic strategy against this metabolic syndrome. New thiazolidine-4-one...
Although niflumic acid (NA) is one of the most used non-steroidal anti-inflammatory drugs, it suffers from poor solubility, low bioavailability, and significant adverse effects. To address these limitations, complexation NA with cyclodextrins (CDs) a promising strategy. However, complexing CDs molecular weight drugs like can lead to CE. This study explores development inclusion complexes 2-hydroxypropyl-β-cyclodextrin (2HP-β-CD), including effect converting its sodium salt (NAs) adding...
In the past many research studies have focused on thiazolidine-4-one scaffold, due to important biological effects associated with its heterocycle. This scaffold is present in structure of synthetic compounds, which showed significant such as antimicrobial, antifungal, antioxidant, anti-inflammatory, analgesic, antidiabetic effects. It was also identified natural actithiazic acid, isolated from Streptomyces strains. Starting this new xanthine derivatives been synthetized and evaluated for...
Starting from indomethacin (IND), one of the most prescribed non-steroidal anti-inflammatory drugs (NSAIDs), new nitric oxide-releasing derivatives with 1,3,4-oxadiazole-2-thiol scaffold (NO-IND-OXDs, 8a-p) have been developed as a safer and more efficient multitarget therapeutic strategy. The successful synthesis designed compounds (intermediaries finals) was proved by complete spectroscopic analyses. In order to study in silico interaction NO-IND-OXDs cyclooxygenase isoenzymes, molecular...
Generally, NSAIDs are weakly soluble in water and contain both hydrophilic hydrophobic groups. One of the most widely used is ibuprofen, which has a poor solubility high permeability profile. By creating dynamic, non-covalent, water-soluble inclusion complexes, cyclodextrins (CDs) can increase dissolution rate low aqueous drugs, operating as drug delivery vehicle, additionally contributing significantly to chemical stability pharmaceuticals reducing drug-related irritability. In order...
The synthesis of a new xanthine nitric oxide donor (TSP-81) has been discussed. designed compound includes two structural moieties - theophylline (1,3-dimethylxanthine) and acetaminophen (4-hydroxyacetanilide) linked by the alkyl chain as spacer. characterized microanalysis (CHN), 1H-NMR, 13C-NMR, FT-IR, UV-vis, TG DTG. thermal behaviour showed that TSP-81 melts with decomposition, in four steps, most important ones being 2nd one (the registered weight loss 17.6 %) 3rd (with 30.4 %)....
Type 2 Diabetes Mellitus (T2DM) is one of the most common metabolic disorders, with a major involvement oxidative stress in its onset and progression. Pioglitazone (Pio) an antidiabetic drug which primarily works by reducing insulin resistance while Curcumin (Cur) powerful antioxidant o important hypoglycemic effect, also. The both drugs are associated several drawbacks, such as reduced bioavailability, short half-life time well instability poor water solubility (Cur), limit their...
Aim:The aim of the present study was to design and optimize method used for preparation CS NPs loaded with pioglitazone (P) curcumin (C), as a new multi-target polymeric nanosystems, type 2 diabetes mellitus therapy.Material methods: pioglitazone, pioglitazone-curcumin were prepared using ionic gelation method.After setting optimal parameters, developed nanosystems (CS_P NPs, CS_C NP CS_P_C NPs) characterized in terms morphological aspects, Scanning Electronic M icroscopy (SEM) average...
This study presents the production, characterization, and application of celandine (Chelidonium majus L.) extracts (aqueous, acidic, alcoholic, ultrasound) on wool fibers their characterization. The aims to obtain an ecologically dyed support that possesses biocompatible antimicrobial activities. plant were characterized based pH, total polyphenol content, berberine content. Ecologically supports scanning electron microscopy, levelness index, color measurements, contact angle indirect...