A5009609969- Endometriosis Research and Treatment
- Ovarian cancer diagnosis and treatment
- Thyroid Cancer Diagnosis and Treatment
- Protease and Inhibitor Mechanisms
- Wnt/β-catenin signaling in development and cancer
- Cancer Immunotherapy and Biomarkers
- Wound Healing and Treatments
- Peptidase Inhibition and Analysis
- Cancer Cells and Metastasis
- Cancer, Lipids, and Metabolism
- Regulation of Appetite and Obesity
- Endometrial and Cervical Cancer Treatments
- Thyroid and Parathyroid Surgery
- Genetic factors in colorectal cancer
- Cervical Cancer and HPV Research
- Cardiovascular Disease and Adiposity
- Cardiac Fibrosis and Remodeling
- Systemic Lupus Erythematosus Research
- Electrospun Nanofibers in Biomedical Applications
- Liver Disease Diagnosis and Treatment
- Asthma and respiratory diseases
- Cancer Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Cancer, Hypoxia, and Metabolism
- Testicular diseases and treatments
Grigore T. Popa University of Medicine and Pharmacy
2016-2025
Spitalul Clinic Dr. C. I. Parhon
2021-2024
Spitalul Clinic Judeţean de Urgenţe "Sf. Spiridon" Iaşi
2008-2014
New membranes based on chitosan and chitosan-hyaluronic acid containing new arginine derivatives with thiazolidine-4-one scaffold have been prepared using the ionic cross-linking method. The presence of into polymer matrix was proved by Fourier-transform infrared spectroscopy (FT-IR). scanning electron microscopy (SEM) revealed a micro-porous structure that is an important characteristic for treatment burns, favoring exudate absorption, rate colonization, cell structure, angiogenesis...
Human papillomavirus-positive (HPV+) tonsillar and base of tongue squamous cell carcinoma (TSCC/BOTSCC) have better outcome than corresponding HPV- cancers. To individualize treatment, additional predictive markers are needed. Previously, we shown that mutated fibroblast growth factor receptor 3 protein (FGFR3) was correlated to poorer prognosis here FGFR3 expression further analyzed.One-hundred-fifteen HPV+TSCC/ BOTSCC biopsies were analyzed for by immunohistochemistry (IHC), 109/115...
Atherosclerosis (ATS) is still considered as a major, global health problem. For deeper understanding of its pathogenesis, in the last years research was translated from tissue visible events to molecular mechanisms. Osteopontin (OPN) and osteoprotegerin (OPG) are two molecules that have been associated with initiation progression ATS lesions. The aim our study assess OPN OPG expression advanced stages carotid ATS, analyze correlation between these markers ultrasonographic plaque properties,...
Ghrelin, an orexigenic hormone, is a peptide that binds to the growth hormone secretagogue receptor; it secreted mainly by enteroendocrine cells in oxyntic glands of stomach. Ghrelin serves role both local and systemic physiological processes, implicated various pathologies, including neoplasia, with tissue expression several types malignancies <em>in vitro</em> vivo</em> studies. However, precise implications ghrelin axis metastasis, invasion cancer progression regulation has yet be...
Introduction. The impact of tumor cells on tumor-infiltrating lymphocytes (TILs) in cancer development is not yet clarified. Our study analyzed the distribution and prognostic value CD4+ CD8+ T hepatocellular carcinoma (HCC) liver metastases (LM). Material methods. Archival tissue specimens 35 HCC 39 LM patients were immunohistochemically processed. number intratumoral (IT) peritumoral (PT) was quantitatively analyzed. Results. We noted large variances lymphocyte subpopulations. Similar...
Background/Aim: Placenta percreta is a rare event, but it poses serious problems due to potential hemorrhagic events. We report particular case of placenta with massive hematuria maternal bladder invasion, and describe the surgical protocol performed that resulted in an excellent outcome. Case Report: A 33-year-old patient, at 27<sup>th</sup> weeks gestational age, presented emergency room Urology Department urinary blood clot acute retention, because from invasion. After extracting clots...
Ovarian cancer (OC) still registers a high prevalence in female gynecological pathology. Given the aggressiveness of tumor and lack response to conventional therapies, current research interest is identification new prognostic markers. Gal-8, member galectin family molecules, involved tumorigenesis, disease progression, metastasis, has been assigned as valuable factor, its inhibition may open perspectives therapeutic management. Few studies have carried out so far evaluate OCs’ profiles. Our...
Background and Objectives: The most common mutation in malignant melanoma (MM) is the single-point of v-raf murine sarcoma viral oncogene homolog B1 (BRAF) oncogene. Our study aims to evaluate BRAF V600E mutation, highlighting its frequency differences primary versus metastatic MM. Materials Methods: group comprised 133 patients diagnosed with MM several county hospitals north-eastern region Romania who have been assigned for investigation into private medical system. material consisted...