A5021989180- Synthesis and biological activity
- Computational Drug Discovery Methods
- Nanocomposite Films for Food Packaging
- Inflammatory mediators and NSAID effects
- Potassium and Related Disorders
- Analytical Methods in Pharmaceuticals
- Heart Failure Treatment and Management
- Natural Antidiabetic Agents Studies
- Free Radicals and Antioxidants
- Air Quality and Health Impacts
- Curcumin's Biomedical Applications
- Synthesis of heterocyclic compounds
- Empathy and Medical Education
- Wound Healing and Treatments
- Analytical Chemistry and Chromatography
- Eicosanoids and Hypertension Pharmacology
- Antimicrobial agents and applications
- Biochemical effects in animals
- Pharmaceutical studies and practices
- Multicomponent Synthesis of Heterocycles
- Advanced Drug Delivery Systems
- Catalytic C–H Functionalization Methods
- Analytical Chemistry and Sensors
- Catalytic Cross-Coupling Reactions
- Cardiac electrophysiology and arrhythmias
Grigore T. Popa University of Medicine and Pharmacy
2017-2024
Spitalul Clinic C.F. Iasi
2024
Institut de Chimie Organique et Analytique
2021-2022
Université d'Orléans
2021-2022
Centre National de la Recherche Scientifique
2021-2022
Institute of Environmental Protection
2019
Wound management represents a continuous challenge for health systems worldwide, considering the growing incidence of wound-related comorbidities, such as diabetes, high blood pressure, obesity, and autoimmune diseases. In this context, hydrogels are considered viable options since they mimic skin structure promote autolysis growth factor synthesis. Unfortunately, associated with several drawbacks, low mechanical strength potential toxicity byproducts released after crosslinking reactions....
Type 2 diabetes mellitus (T2DM) is one of the most common metabolic disorders, with a major involvement oxidative stress in its onset and progression. Pioglitazone (Pio) an antidiabetic drug that mainly works by reducing insulin resistance, while curcumin (Cur) powerful antioxidant important hypoglycemic effect. Both drugs are associated several drawbacks, such as reduced bioavailability short half-life time (Pio), well instability poor water solubility (Cur), which limit their therapeutic...
The growing popularity of electronic cigarettes has raised several public health concerns, including the risks associated with heavy metals exposure via e-liquids and vapors. purpose this study was to determine, using atomic absorption spectrometry, concentrations Pb, Ni, Zn, Co in some commercially available e-liquid samples from Romania immediately after purchase storage clearomizers. Lead zinc were found all investigated before storage. initial Pb ranged 0.13 0.26 mg L-1, while Zn between...
In the past many research studies have focused on thiazolidine-4-one scaffold, due to important biological effects associated with its heterocycle. This scaffold is present in structure of synthetic compounds, which showed significant such as antimicrobial, antifungal, antioxidant, anti-inflammatory, analgesic, antidiabetic effects. It was also identified natural actithiazic acid, isolated from Streptomyces strains. Starting this new xanthine derivatives been synthetized and evaluated for...
Starting from indomethacin (IND), one of the most prescribed non-steroidal anti-inflammatory drugs (NSAIDs), new nitric oxide-releasing derivatives with 1,3,4-oxadiazole-2-thiol scaffold (NO-IND-OXDs, 8a-p) have been developed as a safer and more efficient multitarget therapeutic strategy. The successful synthesis designed compounds (intermediaries finals) was proved by complete spectroscopic analyses. In order to study in silico interaction NO-IND-OXDs cyclooxygenase isoenzymes, molecular...
The first access to 3,5-disubstituted imidazo[1,2-d][1,2,4]thiadiazole derivatives is reported. series were generated from 2-mercaptoimidazole, which afforded the key intermediate bearing two functional positions. SNAr reactivity toward tosyl release at C-3 position was investigated and a regioselective electrophilic iodination in C-5 performed allow novel C-C bond using Suzuki-Miyaura reaction. Palladium-catalyzed cross-coupling conditions optimized. A representative library of various...
In this study we present design and synthesis of nineteen new nitric oxide-releasing indomethacin derivatives with 1,3-thiazolidine-4-one scaffold (NO-IND-TZDs) (6a–s), as a safer efficient multi-targets strategy for inflammatory diseases. The chemical structure all synthesized (intermediaries finals) was proved by NMR mass spectroscopic analysis. order to the selectivity NO-IND-TZDs COX isoenzymes (COX-1 COX-2) molecular docking performed using AutoDock 4.2.6 software. Based on results,...
The aim of the study was to optimize synthesis diclofenac derivative with hydrazones structure in order obtain higher yields and purity by variation different parameters such as: ratio between reactants, solvent, catalyst, temperature, time reaction method used. anti-inflammatory effects derivatives were evaluated using vitro assays: albumin denaturation erythrocyte membrane stability. obtained results showed that effect tested is increasing concentration, best being at concentration 125...
Type 2 Diabetes Mellitus (T2DM) is one of the most common metabolic disorders, with a major involvement oxidative stress in its onset and progression. Pioglitazone (Pio) an antidiabetic drug which primarily works by reducing insulin resistance while Curcumin (Cur) powerful antioxidant o important hypoglycemic effect, also. The both drugs are associated several drawbacks, such as reduced bioavailability, short half-life time well instability poor water solubility (Cur), limit their...
Drug-drug interactions are a major cause of adverse reactions in polypharmacy, the incidence being directly proportional to number associated drugs. In this work, we highlighted main drug-drug that occurred treatment gastrointestinal symptoms with proton pump inhibitors and histamine H2-receptor antagonists. The two groups agents, used gastroesophageal reflux ulcer disease, can be released without prescription on recommendation pharmacist, contributing risk emergence interactions. occur due...
Aim:The aim of the present study is to discover new approaches for old drugs, targeting heart failure (HF), using in silico studies.Material and methods: Several belong different chemical therapeutical classes: oral hypoglycemic drugs (sulfonyl urea), proton pump inhibitors, nonsteroidal anti-inflammatory statins, H 1 /H 2 antagonists, antineoplastic alfa-adrenergic agonists, vitamins antioxidants, were tested affinity glycogen synthase kinase 3 beta (GSK-3β), molecular docking...
Effective communication is an essential part of pharmacy practice aimed to ensured counsel patients about their prescribed medicines. This will lead a rational use medicine with improved therapeutic outcome, increasing compliance and decreasing confusion insecurity. For the purpose legal regulation pharmacist-patient communication, professional associations from different countries have developed codes ethics for pharmacists. As in other countries, Code Ethics Pharmacists Romania Law 81/1997...