A5030422128- Synthesis and biological activity
- Free Radicals and Antioxidants
- Computational Drug Discovery Methods
- Synthesis and Characterization of Heterocyclic Compounds
- Advanced Drug Delivery Systems
- Phytochemicals and Antioxidant Activities
- Synthesis and Reactions of Organic Compounds
- Natural Antidiabetic Agents Studies
- Nanocomposite Films for Food Packaging
- Synthesis of heterocyclic compounds
- Analytical Chemistry and Chromatography
- Analytical Methods in Pharmaceuticals
- Inflammatory mediators and NSAID effects
- Bioactive Compounds and Antitumor Agents
- Nanoparticle-Based Drug Delivery
- Seaweed-derived Bioactive Compounds
- Chronic Lymphocytic Leukemia Research
- Biochemical effects in animals
- Fungal Plant Pathogen Control
- Multicomponent Synthesis of Heterocycles
- Immunodeficiency and Autoimmune Disorders
- Cancer therapeutics and mechanisms
- Enzyme function and inhibition
- Chemical synthesis and pharmacological studies
- Crystallography and molecular interactions
Grigore T. Popa University of Medicine and Pharmacy
2013-2024
Alexandru Ioan Cuza University
2019
Type 2 diabetes mellitus (T2DM) is one of the most common metabolic disorders, with a major involvement oxidative stress in its onset and progression. Pioglitazone (Pio) an antidiabetic drug that mainly works by reducing insulin resistance, while curcumin (Cur) powerful antioxidant important hypoglycemic effect. Both drugs are associated several drawbacks, such as reduced bioavailability short half-life time (Pio), well instability poor water solubility (Cur), which limit their therapeutic...
The xanthine structure has proved to be an important scaffold in the process of developing a wide variety biologically active molecules such as bronchodilator, hypoglycemiant, anticancer and anti-inflammatory agents. It is known that hyperglycemia generates reactive oxygen species which are involved progression diabetes mellitus its complications. Therefore, development new compounds with antioxidant activity could therapeutic strategy against this metabolic syndrome. New thiazolidine-4-one...
The roots of Vernonia kotschyana Sch. Bip. ex Walp. (Asteraceae) are used in Malian traditional medicine the treatment gastroduodenal ulcers and gastritis. Since oxidative stress is involved gastric ulceration, aim this study was to screen root extracts for their vitro antioxidant activity phenolic content. were extracted successively with chloroform, ethyl acetate, ethanol water. evaluated both cell-free cell-based assays. Their chemical characterization performed by Fourier transform...
New thiazolidine-4-one derivatives of 2-(4-isobutylphenyl)propionic acid (ibuprofen) have been synthesized as potential anti-inflammatory drugs. The structure the new compounds was proved using spectral methods (FR-IR, 1H-NMR, 13C-NMR, MS). in vitro antioxidant evaluated according to total activity, DPPH and ABTS radical scavenging assays. Reactive oxygen species (ROS) free radicals are considered be involved many pathological events like diabetes mellitus, neurodegenerative diseases,...
l-Arginine is a semi-essential aminoacid with important role in regulation of physiological processes humans. It serves as precursor for the synthesis proteins and also substrate different enzymes such nitric oxide synthase. This amino-acid act free radical scavenger, inhibits activity pro-oxidant thus acts an antioxidant has bactericidal effect against broad spectrum bacteria.New thiazolidine-4-one derivatives nitro-l-arginine methyl ester (NO2-Arg-OMe) have been synthesized biologically...
In the past many research studies have focused on thiazolidine-4-one scaffold, due to important biological effects associated with its heterocycle. This scaffold is present in structure of synthetic compounds, which showed significant such as antimicrobial, antifungal, antioxidant, anti-inflammatory, analgesic, antidiabetic effects. It was also identified natural actithiazic acid, isolated from Streptomyces strains. Starting this new xanthine derivatives been synthetized and evaluated for...
New thiazolidine-4-one derivatives based on the 4-aminophenazone (4-amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one) scaffold have been synthesized as potential anti-inflammatory drugs. The pyrazoline are known especially for their antipyretic, analgesic and effects, but recently there were new compounds with important antioxidant, antiproliferative, anticancer antidiabetic activities. beneficial effects of these explained by nonselective inhibition cyclooxygenase izoenzymes, also scavenging...
This work reports the design of [1,3,4]thiadiazolo[3′,2′:1,2]imidazo[4,5-c]quinolines using a Pictet–Spengler reaction. The scope reaction was achieved from 6-(2-aminophenyl)imidazo[2,1-b][1,3,4]thiadiazole derivatives and available aldehydes. A wide range aldehydes were employed to examine cyclization. In parallel, mechanism investigation realized showed hydride transfer which led dismutation intermediate species. To complete this methodological study, "sequential" oxidation/SNAr procedure...
A series of diclofenac hydrazones was synthesized and the structure compounds proved using different spectral methods such as infrared (IR), nuclear magnetic resonance ( 1 H-NMR) high resolution mass spectroscopy (HR-MS).The biological evaluation, focused on in vitro antioxidant effects DPPH (2,2-diphenyl-1-picrylhydrazyl) ABTS (2,2'azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid)) free radicals scavenging assays also performed.An improved effect compared to observed. RezumatO serie de...
The aim of the study was to optimize synthesis diclofenac derivative with hydrazones structure in order obtain higher yields and purity by variation different parameters such as: ratio between reactants, solvent, catalyst, temperature, time reaction method used. anti-inflammatory effects derivatives were evaluated using vitro assays: albumin denaturation erythrocyte membrane stability. obtained results showed that effect tested is increasing concentration, best being at concentration 125...
Generally, NSAIDs are weakly soluble in water and contain both hydrophilic hydrophobic groups. One of the most widely used is ibuprofen, which has a poor solubility high permeability profile. By creating dynamic, non-covalent, water-soluble inclusion complexes, cyclodextrins (CDs) can increase dissolution rate low aqueous drugs, operating as drug delivery vehicle, additionally contributing significantly to chemical stability pharmaceuticals reducing drug-related irritability. In order...
Type 2 Diabetes Mellitus (T2DM) is one of the most common metabolic disorders, with a major involvement oxidative stress in its onset and progression. Pioglitazone (Pio) an antidiabetic drug which primarily works by reducing insulin resistance while Curcumin (Cur) powerful antioxidant o important hypoglycemic effect, also. The both drugs are associated several drawbacks, such as reduced bioavailability, short half-life time well instability poor water solubility (Cur), limit their...