A5002296505- Nanocomposite Films for Food Packaging
- Antifungal resistance and susceptibility
- Advanced Drug Delivery Systems
- Nanoparticles: synthesis and applications
- Plant Pathogens and Fungal Diseases
- Fungal Infections and Studies
- Antimicrobial agents and applications
- Plasma Applications and Diagnostics
- Phenothiazines and Benzothiazines Synthesis and Activities
- Drug Solubulity and Delivery Systems
- Cancer therapeutics and mechanisms
- Bee Products Chemical Analysis
- Pneumocystis jirovecii pneumonia detection and treatment
- Wound Healing and Treatments
- Yeasts and Rust Fungi Studies
- Essential Oils and Antimicrobial Activity
- Indoor Air Quality and Microbial Exposure
- Probiotics and Fermented Foods
- Click Chemistry and Applications
- Synthesis and Characterization of Heterocyclic Compounds
- Hydrogen's biological and therapeutic effects
- Synthesis and Biological Activity
- Phytochemistry and Bioactive Compounds
- Synthesis and Reactivity of Heterocycles
- Foreign Body Medical Cases
"Ion Ionescu de la Brad" Iasi University of Life Sciences
2015-2024
Introduction: Duodenoscopes have been widely used for both diagnostic and therapeutic endoscopic retrograde cholangiopancreatography procedures. Numerous outbreaks of duodenoscope-associated infections involving multidrug-resistant bacteria recently reported. Plasma activated water (PAW) has considered an effective agent surface decontamination is increasingly disinfection medical equipment. The aim this study was to evaluate whether the duodenoscopes currently on market are suited repeated...
The impetus for research into hydrogels based on selectively oxidized polysaccharides has been stimulated by the diversity of potential biomedical applications. Towards development a hemostatic wound dressing in this study, we creatively combined (hemi)acetal and Schiff base bonds to prepare series multifunctional cryogels dialdehyde pullulan dopamine. designed structures were verified NMR FTIR spectroscopy. Network parameters dynamic sorption studies correlated with environmental scanning...
Cerium oxide nanoparticles present the mimetic activity of superoxide dismutase, being able to inactivate excess reactive oxygen species (ROS) correlated with a large number pathologies, such as stents restenosis and occurrence genetic mutations that can cause cancer. This study presents synthesis biological characterisation nanoconjugates based on iron interconnected cerium conjugates.The magnetite-nanoceria has been done in several stages, where key process is coating polyethyleneimine its...
Non-thermal plasma activated water (PAW) has recently emerged as a powerful antimicrobial agent. Despite numerous potential bio-medical applications, studies concerning toxicity in live animals, especially after long-term exposure, are scarce. Our study aimed to assess the effects of watering with PAW on health CD1 mice. was prepared from distilled GlidArc reactor according previously published protocol. The pH 2.78. mice received (experimental group) or tap (control daily for 90 days sole...
In this paper, we aim at understanding the broad spectrum of factors influencing survival infected patients and correlations between these to create a predictive probabilistic score for surviving COVID-19 disease. Initially, 510 hospital admissions were counted in study, out which 310 did not survive. A prediction model was developed based on data by using Bayesian approach. Following collection process development second cohort totaling 541 built validate risk matrix previously created. The...
Abstract Fungal flora in coastal/inland beach sand and recreational water is a neglected field of study, despite its potential impact on human health. A joint ISHAM/ECMM working group was formed 2019 with the task to set up vast international initiative aimed at studying fungal contamination beaches bathing waters. Here we review importance topic, list main results achievements from 12 scientific publications. exists different levels genera most frequently found were Aspergillus spp.,...
Cancer is a big challenge of the 21 century, whose defeat requires efficient antitumor drugs. The paper aims to investigate synergistic effect two structural building blocks, phenothiazine and poly(ethylene glycol), towards Two PEGylated derivatives were synthetized by attaching glycol) 550 Da nitrogen atom ether or ester linkage. Their activity has been investigated on five human tumour lines mouse tumor line as well, determination IC50. in vivo toxicity was determined measuring LD50 BALB/c...
The paper deals with new approaches to chitosan (CS)-based antifungal therapeutic formulations designed fulfill the requirements of specific applications. Gel-like were prepared by mixing CS dissolved in aqueous lactic acid (LA) solution nystatin (NYS) powder and/or propolis (PRO) dispersed glycerin, followed water evaporation yield flexible mesoporous (pore widths 2-4 nm) films high surfaces between 1 × 103 and 1.7 m2/g. Morphological evaluation showed uniform dispersion downsizing NYS...
To avoid fungal spreading in the bloodstream and internal organs, many research efforts concentrate on finding appropriate candidiasis treatment from initial stage. This paper proposes chitosan-based physically or chemically cross-linked hydrogels aimed to provide sustained release of micronized nystatin (NYSm) antifungal drug, known for its large activity spectrum. Nystatin was demonstrated itself hydrodynamic/mechanic stability chitosan hydrogel through hydrophobic interactions H-bonds....
Steady developments made in nanotechnology-based products have facilitated new perspectives for combating drug-resistant fungi. Silver nanoparticles represent one of the most attractive nanomaterials biomedicine due to their exclusive optical, electromagnetic, and catalytic properties antifungal potency compared with other metal nanoparticles. Most studies show that physicochemical parameters affecting potential AgNPs include shape, size, surface charge, concentration colloidal state. For...
The paper aimed to prepare imino-chitosan fibers by the imination reaction in a heterogenous system, targeting improvement of anti-pathogenic activity. To this end, porous neat chitosan were prepared electrospinning polyethylene glycol/chitosan blend, followed glycol removal. Imination was carried out three liquid phase systems using solvents different polarity and, consequently, ability swell solid fibers. successful qualitatively and quantitatively assessed FTIR 1H-NMR spectroscopy, impact...
Dermatophyte infections represent a significant public health concern, with an alarming negative impact caused by unsuccessful therapeutic regimens. Natural products have been highlighted as promising alternative, due to their long-standing traditional use and increasing scientific recognition. In this study, honokiol magnolol, the main bioactives from
Dermatophyte infections represent an important public health concern, affecting up to 25% of the world's population. Trichophyton rubrum and T. mentagrophytes are predominant dermatophytes in cutaneous infections, with a prevalence accounting for 70% dermatophytoses. Although terbinafine represents preferred treatment, its clinical use is hampered by side effects, drug-drug interactions, emergence resistant isolates. Combination therapy, associating essential oils (EOs), promising strategy...
The aim of this study was to synthesize silver nanoparticles (AgNPs) using cellulose derivatives and evaluate their antimicrobial potential. As effective reducing stabilizing agents for AgNPs, derivatives, such as hydroxypropyl (HPC), methylcellulose (MC), ethylcellulose (EC), acetate (CA), were used. Their ability reduce ions well the size resulting AgNPs compared. formation stability reduced in solution monitored UV-Vis analysis. size, morphology, charge evaluated. We found that, when...
In this study, we proposed formulations of diminazene aceturate (DA) designed to improve its bioavailability and maximize the therapeutic index in animals by overcoming rapid degradation under acidic pH stomach. An important consequence is fact that amount bloodstream close administered dose. This was made possible incorporating DA into β-cyclodextrin's (βCD) cavity a molar ratio 1:1. The structure resulted inclusion complex established Raman, DSC, Wide-Angle X ray Diffraction (WAXD) solid...
Abstract Background : During the last two decades a major increase in proportion of severe fungal infections has been noted due to excessive use broad-spectrum antibiotics, catheters, and growing number immunocompromised patients. Objectives This is first investigation providing complete data regarding phenotypic genotypic profiles Candida albicans (C. albicans) isolates Romanian Methods We investigated 301 terms genotype determination (G), resistogram (R), phospholipase activity (Pl),...
Eliminating or at least lessening the pain is a crucial aspect of burns management, as can negatively affect mental health and quality life, it also induce delay on wound healing. In this context, new amphiphilic chitosan 3D porous membranes were developed investigated therapeutic systems with analgesic effect for delivery lidocaine local anesthetic. The highly morphology structural modifications evidenced by scanning electron microscopy (SEM), energy dispersive X-ray (EDX) analysis infrared...
Abstract Background : Fungal infections are a health issue paradoxically fuelled by the developments in medical care. Objectives: Our study is an investigation on correlation between infection site and genotypes of Candida albicans strains isolated from Romanian patients. Methods A total number 301 isolates different clinical sites were investigated terms genotype determination. Results The clustered three groups according to their genotype: 55.81% showed A, 14.62% B, 29.57% C. Conclusions...
The aim of this paper is to emphasize an important practical aspect concerning the interaction between non-thermal plasma activated water (PAW) and plastic materials (i.e. polycarbonate) with severe consequences on living organisms' health status in case ingestion. For study, PAW was produced using a gliding arc reactor. experiment conducted total number 45 outbred female mice, CD1 strain, 3-week-old, divided into three groups. mice received drinking as follow: group A - tap water, B...