A5052741281- Acute Lymphoblastic Leukemia research
- Chronic Lymphocytic Leukemia Research
- Acute Myeloid Leukemia Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Chronic Myeloid Leukemia Treatments
- Lipoproteins and Cardiovascular Health
- Multiple Myeloma Research and Treatments
- Cancer Immunotherapy and Biomarkers
- Prenatal Screening and Diagnostics
- Surgical site infection prevention
- Lymphoma Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Immune Cell Function and Interaction
- Cancer Diagnosis and Treatment
- Protein Degradation and Inhibitors
- Neutropenia and Cancer Infections
- Metastasis and carcinoma case studies
- Immunodeficiency and Autoimmune Disorders
- Endometrial and Cervical Cancer Treatments
- Cancer Risks and Factors
- Chromosomal and Genetic Variations
- Congenital heart defects research
- Plasma Applications and Diagnostics
- Urinary Tract Infections Management
- Genomic variations and chromosomal abnormalities
Institutul Regional de Oncologie
2015-2025
Grigore T. Popa University of Medicine and Pharmacy
2011-2019
Flatiron Health (United States)
2017
Spitalul Clinic Judeţean de Urgenţe "Sf. Spiridon" Iaşi
2011-2012
Introduction Antibiotic overuse is driving a global rise in antibiotic resistance, highlighting the need for robust antimicrobial stewardship (AMS) initiatives to improve prescription practices. While antimicrobials are essential treating sepsis and preventing surgical site infections (SSIs), they can inadvertently disrupt gut microbiota, leading postoperative complications. Treatment methods vary widely across nations due differences drug choice, dosage, therapy duration, affecting...
This study aimed to identify and analyse the copy number variations (CNVs) in genes involved pathophysiology of obesity correlate these findings with phenotypic manifestations. Genetic screening 59 apparently healthy individuals elevated adipose tissue percentages was performed, assessing duplications deletions obesity-related through MLPA (Multiplex Ligation-dependent Probe Amplification) technique. Clinical metabolic parameters, including insulin, HOMA-IR, leptin, adiponectin levels, were...
Acute myeloid leukemia (AML) is generally considered a poorly immunogenic malignancy, displaying "non-inflamed" microenvironment, leading to T cell tolerance. However, the immune landscape of AML much more heterogeneous. Since B7 expression regarded as consequence an interferon-mediated "inflammatory" phenotype, we have investigated by flow cytometry checkpoint ligands B7.1, B7.2, PD-L1, PD-L2, ICOS-L, B7-H3, B7-H4 on blasts 30 newly diagnosed patients, and their corresponding receptors...
Soil microorganisms, especially rhizobacteria, play a key role in soil phosphorus (P) dynamics and the subsequent availability of phosphate to plants. Utilization phosphate-solubilizing bacteria as biofertilizers instead synthetic chemicals is known improve plant growth through supply nutrients, may help sustain environmental health productivity. The main purpose this study was identify new isolated from runner bean rhizosphere. Ten out 25 bacterial strains solubilized Ca3(PO4)2 qualitative...
Over the past decade, cold atmospheric plasma (CAP) has undergone extensive research as a promising therapeutic approach in oncology, with different treatment methods and exposure configurations being investigated resulting various biological effects, most of them after long or durations. This study aimed to evaluate potential custom-made CAP generation source produce plasma-activated medium (PAM) cytotoxic effects subsequently establish optimal parameters. The exposure’s electrical...
Intellectual disability (ID) is a common disorder, with major consequences for individual, family and society. Due to clinical genetic heterogeneity of ID, in about 50% cases an etiologic diagnosis cannot be established. The aim this study was evaluate the ability combination MLPA kits establish 369 patients syndromic ID normal or uncertain routine karyotype results. All were assessed chromosome imbalance using SALSA P064 P096 kits, if phenotype suggestive microdeletion syndrome (subgroup A...
Background: The prevalence of melanoma in Romanian patients is underestimated. There a need to identify the BRAF V600E mutation accurately treat with newest approved inhibitor therapy. This pilot study which we first aimed choose optimal DNA purification method from formalin fixation and paraffin embedding (FFPE) malignant skin samples assess correlate it clinical pathological parameters. Methods: 30 FFPE were purified parallel two extraction kits, manual semi-automated kit. extracted pure...
Introduction The intestinal microbiota is vital to human health, and has a profound influence on several biological processes including inflammation pathogen resistance. Antibiotic intake greatly impacts bacterial diversity, can increase antibiotic resistance impair the equilibrium between species. key grasping post-antibiotic effects gut rests implementation of suitable procedure isolate microbial DNA meticulous consideration experimental sequencing artefacts. Methods We herein report...
Abstract Background: Acute basophilic leukemia is a rare subtype of acute myeloid leukemia, as categorized by the 2008 World Health Organization classification neoplasms. diagnosis requires thorough morphological, cytochemical, immunophenotypic, molecular, and cytogenetic studies exclusion other hematological neoplasms associating basophilia. The disease course defined histamine driven, occasionally life-threatening respiratory, cardiovascular, cutaneous or digestive complications, well...
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