A5076495670- Cardiovascular Disease and Adiposity
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Heart Failure Treatment and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Blood Pressure and Hypertension Studies
- Coronary Interventions and Diagnostics
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular Health and Disease Prevention
- GDF15 and Related Biomarkers
- Antioxidant Activity and Oxidative Stress
- Nutrition and Health in Aging
- Lipoproteins and Cardiovascular Health
- Nutritional Studies and Diet
- Biomarkers in Disease Mechanisms
- Acute Myocardial Infarction Research
- Urinary Tract Infections Management
- Vitamin K Research Studies
- Cardiac electrophysiology and arrhythmias
- Tryptophan and brain disorders
- Antibiotic Use and Resistance
- Antibiotic Resistance in Bacteria
- Genetics, Bioinformatics, and Biomedical Research
- Biomedical and Engineering Education
- Pharmacological Effects and Assays
Grigore T. Popa University of Medicine and Pharmacy
2019-2025
Morpho (United States)
2022
Spitalul Clinic Judeţean de Urgenţe "Sf. Spiridon" Iaşi
2019
(1) Background: Antibiotic resistance and coronavirus disease-19 (COVID-19) represent a dual challenge in daily clinical practice, inducing high burden on public health systems. Hence, we aimed to dynamically evaluate the impact of COVID-19 patients with carbapenem-resistant Enterobacterales (CRE) urinary tract infections (UTIs), as well antibiotic trends after onset pandemic. (2) Methods: We conducted prospective study including CRE UTIs who were enrolled both pre- during pandemic from 2019...
The present study aimed to explore the correlations between clinical, biological, imagistic and procedural factors with risk of intra‑stent restenosis (ISR) in coronary artery disease (CAD) patients after percutaneous intervention (PCI). An observational cross‑sectional was conducted a high‑volume PCI center over period 2 years. A total 235 consecutive diagnosed angina or acute syndrome treated by were included study. Diagnosis ISR documented angiography suggestive symptoms ischemic changes...
Background and Objectives: Despite the latest advancements in interventional procedures pharmacological therapy, incidence of heart failure death rate following an acute myocardial remain unacceptably high. This study was designed response to limited conflicting literature data regarding diagnostic prognostic role modern inflammatory biomarkers patients with coronary artery disease. Materials Methods: We conducted a case-control, prospective observational study. A total 145 were analyzed,...
This study aimed to identify and analyse the copy number variations (CNVs) in genes involved pathophysiology of obesity correlate these findings with phenotypic manifestations. Genetic screening 59 apparently healthy individuals elevated adipose tissue percentages was performed, assessing duplications deletions obesity-related through MLPA (Multiplex Ligation-dependent Probe Amplification) technique. Clinical metabolic parameters, including insulin, HOMA-IR, leptin, adiponectin levels, were...
The current cardiovascular disease (CVD) primary prevention guidelines prioritize risk stratification by using clinical scores. However, subclinical atherosclerosis may rest long term undetected. This study aimed to evaluate multiple parameters in relation several CV scores asymptomatic individuals. A cross-sectional, single-center included 120 CVD subjects. Four were computed: SCORE, Framingham, QRISK, and PROCAM. Subclinical has been determined carotid intima-media thickness (cIMT), pulse...
(1) Background: Acute heart failure (HF) represents one of the most common yet extremely severe presentations in emergency services worldwide, requiring prompt diagnosis, followed by an adequate therapeutic approach, and a thorough risk stratification. Natriuretic peptides (NPs) are currently widely implemented biomarkers acute HF, but due to their lack specificity, they mainly used as ruling-out criteria. Growth differentiation factor-15 (GDF-15) is novel molecule expressing different...
Background: Biomarkers, electrocardiogram (ECG) and Holter ECG are basic, accessible feasible cardiac investigations. The combination of their results may lead to a more complex predictive model that improve the clinical approach in acute heart failure (AHF). main objective was investigate which parameters correlated with usual biomarkers (prohormone N-terminal proBNP, high-sensitive troponin I) patients failure, population from Romania. relationship between certain support future research...
Abdominal fat and fat-free masses report a close association with cardiometabolic risks, therefore this specific body compartment presents more interest than whole-body masses. This research aimed to develop accurate algorithms that predict specifically trunk from easy measure parameters in any setting. The study included 104 apparently healthy subjects, but higher-than-normal percent of adiposity or waist circumference. Multiple linear regression (MLR) artificial neural network (ANN) models...
Epicardial adipose tissue (EAT) is a unique fat depot located around the heart, intimately associated with myocardium and coronary arteries. The secretion of bioactive molecules their interaction neighbouring cardiac tissues makes it an active organ important implications in cardiovascular health disease. In recent years, omics technologies have provided valuable insights into molecular characteristics functional relevance EAT patients atherosclerosis, myocardial infarction, atrial...
In order to establish more e fficient ways prevent metabolic syndrome (MetS) in clinical settings, we need thoroughly understand the physiopathology behind this cluster of risk factors for cardiometabolic di seases.The main point focus concerning MetS still embraces and secretory products abdominal adipose tissue.Our study aims clearly define an adipokine profile patients with assess possible correlations between obesity parameters, bi ochemical markers adipokines.Material methods: This is a...
This research focused on establishing a hierarchy concerning the influence of various biological markers and body composition parameters preventing, diagnosing managing Metabolic Syndrome (MetS). Our cross-sectional cohort study included 104 subjects without any atherosclerotic antecedent pathology, organized in two groups (with MetS). All participants underwent clinical anthropometric measurements, DEXA investigation blood tests for all MetS criteria, together with adiponectin, leptin,...
Assessing the biochemical parameters in patients with pulmonary embolism (PE), deep vein thrombosis (DVT) or both brings complimentary information for cardiovascular (CV) and death risk stratification. The purpose of study was to evaluate association between PE, DVT both. prospective, conducted over a 12-month period included 151 diagnosed pathologies. These were extensively analysed taking into account associated above-mentioned Mean age 59.23 � 18.22 years 55% women. 38.40% had 48.30%...
Background: The present study aimed to investigate the association of obesity phenotypes and quality life (QoL) scales their relationship with fat mass (FM) parameters. Methods: This categorized 104 subjects into 4 based on BMI metabolic syndrome status: metabolically healthy obese (MHO), unhealthy (MUO), non-obese (MHNO), (MUNO). Body composition was measured by dual-energy X-ray absorptiometry (DEXA) profile characterized blood samples. All completed SF-36 item Short Form Health Survey...
Obesity activates multiple pathways of metabolic syndrome (MetS), therefore the balance between adiponectin and leptin, hormones that are secreted by adipocytes, is great interest in better managing understanding this complex disease.The aim our study was to characterize obesity phenotypes circulating levels adipokines insulin, fo llowed a influence lifestyle modification, like physical ctivity, may have upon values these biomarkers.Material methods: Our crosssectional included 104 patients...