A5007883683- Venous Thromboembolism Diagnosis and Management
- Vascular anomalies and interventions
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Heart Failure Treatment and Management
- Cardiac electrophysiology and arrhythmias
- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Disease Prevention
- Cardiovascular Disease and Adiposity
- Cardiac pacing and defibrillation studies
- Cardiovascular Function and Risk Factors
- Lipoproteins and Cardiovascular Health
- Coronary Artery Anomalies
- Blood Coagulation and Thrombosis Mechanisms
- GDF15 and Related Biomarkers
- Inflammatory Biomarkers in Disease Prognosis
- Adrenal and Paraganglionic Tumors
- Birth, Development, and Health
- ECG Monitoring and Analysis
- Inflammasome and immune disorders
- Cancer Risks and Factors
- Muscle and Compartmental Disorders
- Acute Kidney Injury Research
- Machine Learning in Bioinformatics
- Heparin-Induced Thrombocytopenia and Thrombosis
Grigore T. Popa University of Medicine and Pharmacy
2020-2025
Spitalul Clinic Judeţean de Urgenţe "Sf. Spiridon" Iaşi
2018-2025
Chronic kidney disease represents a complex and multifaceted pathology characterized by the presence of structural or functional renal anomalies associated with persistent reduction in function. As progresses, complications arise due to chronic inflammatory syndrome, hydro-electrolytic disorders, toxicity secondary uremic environment. Cardiovascular are leading cause death for these patients. Ischemic cardiac can be both consequence complication disease, highlighting need identify specific...
Background: The subendocardial viability ratio (SEVR), also known as the Buckberg index, is a parameter of arterial stiffness with indirect prognostic value in assessing long-term cardiovascular risk. Materials and Methods: We conducted prospective cohort study on 70 patients uncomplicated hypertension admitted to county medical reference hospital. analyzed demographics, laboratory data, parameters risk scores (SCORE Framingham scores) aimed identify paraclinical associated increased...
(1) Background: Acute heart failure (HF) represents a complex clinical syndrome burdened by increased mortality and high rate of systemic complications. Although natriuretic peptides (e.g., NT-proBNP) currently represent the diagnostic prognostic gold standard in acute HF, those molecules do not accurately reflect all pathophysiological mechanisms involved progression this pathology when determined independently. Therefore, current paradigm tends to focus on multi-marker approach for risk...
Background: Acute pulmonary embolism (PE) is a condition with increased morbidity and mortality. It important to identify patients high mortality risk. Inflammation thrombosis are interconnected in the pathophysiology of PE. The aim study was investigate prognostic value multiple blood cellular indices such as neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte (LMR), platelet-to-lymphocyte (PLR), platelet (NLPR), systemic immune–inflammation index (SII), inflammation response...
The coronavirus pandemic (COVID-19) is a potentially fatal disease that has caused global public health crisis. Its treatment symptomatic because until now the WHO not approved an effective against this disease. This why today hope turned to vaccination curb pandemic. presence of anti-SARSCoV-2 antibodies in serum sick (symptomatic or asymptomatic) and vaccinated individuals must be evaluated for proper understanding natural adaptive immunity. We conducted cross-sectional study 6 months...
The current cardiovascular disease (CVD) primary prevention guidelines prioritize risk stratification by using clinical scores. However, subclinical atherosclerosis may rest long term undetected. This study aimed to evaluate multiple parameters in relation several CV scores asymptomatic individuals. A cross-sectional, single-center included 120 CVD subjects. Four were computed: SCORE, Framingham, QRISK, and PROCAM. Subclinical has been determined carotid intima-media thickness (cIMT), pulse...
Background and Objectives: Atherosclerosis is a multifactorial process in which inflammatory markers have both therapeutic prognostic roles. Recent studies bring into question the importance of assessing new relation to severity peripheral artery disease (PAD), such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR) lymphocyte-to-C-reactive protein (LCR). Materials Methods: We conducted retrospective descriptive study including 652 patients with PAD, who were divided two...
Aim: The definition of fetal growth restriction (FGR) refers to the incapability a fetus achieve appropriate estimated growth, with expected weight below 10 th percentile calculated for its gestational age.Placental factors and hypoxemia are considered be essential elements influence on intrauterine (IUGR) death.The purpose present study was investigate macroscopic microscopic pathological findings regarding placentas in pregnancies complicated by IUGR.Patients, Materials Methods: Our...
Background and Objectives: Chronic heart failure (CHF) caused by ischemic disease (IHD) is the leading cause of death worldwide presents significant health challenges. Effective management IHD requires prevention, early detection, treatment to improve patient outcomes. This study aims expand diagnostic utility various 24 h Holter ECG parameters, such as T-wave alternans (TWA), late ventricular potentials (LVPs), rate variability (HRV) in patients with CHF IHD. Additionally, we seek explore...
Background: Heart failure (HF) is a complex clinical syndrome that represents great burden on public health systems due to its increased prevalence, disability and mortality rates. There are multiple triggers can induce or aggravate preexisting HF, socioeconomic status (SES) emerging as one of the most common modifiable risk factors. Our study aimed analyze influence certain SES indicators outcome, aspects laboratory parameters patients with HF in North-Eastern Romania, well their...
A persistent left superior vena cava (PLSVC) is the most frequent anomaly of venous drainage system. While both a right and (SVC) are usually present, unique, left-sided SVC, also known as an isolated PLSVC, accounts for only 10-20% cases. It frequently associated with arrhythmias other congenital cardiac anomalies. Though it asymptomatic condition, may pose significant problems whenever central access needed. We report case PLSVC that was diagnosed incidentally during pacemaker implantation...
Despite its' life-threatening potential due to cardiac severe dysrhythmia in the context of hypokalemia, thyrotoxic periodic paralysis (TPP) often goes unrecognized. Although classically confined young Asian men, it can occur irrespective age, sex, and race. We report a short series three cases TPP as first presentation Graves' disease Caucasian male two elderly middle-aged women, respectively. The patient developed malignant ventricular arrhythmias hypokalemia was defibrillated, with...
Cardiovascular diseases (CVDs) represent the most important epidemic of our century, with more than 37 million patients globally. Furthermore, CVDs are associated high morbidity and mortality, also increased hospitalization rates poor quality life. Out plethora conditions that can lead to CVDs, atherosclerosis ischemic heart disease responsible for 2/3 cases end in severe failure finally death. Current therapy strategies focus mostly on symptomatic benefits have a moderate impact underlying...
(1) Background: Given its high cardiac specificity and capacity to directly assess the function, myosin-binding protein (MyBP-C) is a promising biomarker in patients with acute heart failure (AHF). The aim of our study was investigate clinical utility this novel marker for diagnosis short-term prognosis subjects AHF. (2) Methods: We measured plasma levels MyBP-C at admission 49 (27 admitted AHF 22 controls). (3) Results: concentration significantly higher compared controls (54.88 vs. 0.01...
(1) Background: Pulmonary embolism (PE) is a severe condition, representing the third most important cardiovascular cause of death after myocardial infarction and stroke. Despite use clinical pre-test probability scores, D-dimer measuring, computer tomography pulmonary angiography (CTPA), PE diagnosis remains challenge. Brain-derived neurotrophic factor (BDNF) member neurotrophin family, which has also been shown to be involved in physiopathology conditions such as heart failure infarction....
Persistent left superior vena cava (PLSVC) is the most common congenital malformation of thoracic venous system, being present in 0.3% to 0.5% general population. In majority cases, PLSVC asymptomatic, but certain patients, it can manifest through several symptoms, such as arrhythmias and cyanosis, especially when associated with complex cardiac pathologies. The clinical significance this anomaly depends on anatomical variant drainage site. article, we will experience our clinic, patients...
The number of infections related to cardiac implantable electronic devices (CIEDs) has increased as the implanted around world grown exponentially in recent years. CIED complications can sometimes be difficult diagnose and manage, case lead-related infective endocarditis. We present a 48-year-old male diagnosed with Staphylococcus aureus device-related endocarditis, 12 years after implant single chamber pacemaker. A history patient includes two urinary catheterizations due obstructive...
This study investigates the potential link between periodontitis and development of hypertension, aiming to assess risk hypertension in individuals with periodontal disease. Periodontitis, a chronic inflammatory condition affecting supporting structures teeth, has been increasingly associated systemic health issues, including cardiovascular diseases. We conducted comprehensive review existing literature analyzed data from clinical studies evaluate prevalence severity patients periodontitis....
Cardiovascular diseases represent the leading cause of mortality worldwide, with recent epidemiological studies revealing an increasing trend prevalence and incidence globally. Among cardiovascular disorders, both arterial venous thrombosis particularly their acute life-threating complications such as ischemic stroke, myocardial infarction, deep pulmonary embolism are responsible for more than 25% all deaths worldwide. The modern approach following progresses in anticoagulant, thrombolytic...
(1) Background: Pulmonary embolism (PE) represents the third most important cardiovascular cause of death after myocardial infarction and stroke. The proper management this condition is dependent on adequate risk stratification, due to life-threatening complications more aggressive therapies such as thrombolysis. Copeptin a surrogate marker vasopressin which found increased in several conditions. Mastora score an imagistic evaluation degree pulmonary arteries thrombotic burden based computed...
Antineutrophil cytoplasm antibody (ANCA)-associated vasculitis usually affects small blood vessels and is characterized by the presence of circulating autoantibodies (c-ANCA or p-ANCA). The risk cardiovascular events threefold higher compared to general population, cardiac manifestations include myocarditis, pericarditis, valvulitis, aortitis, coronary arteritis. Coronary involvement very rare, but it a potentially life-threatening manifestation.
Background: Prevention of sudden cardiac death (SCD) early after acute myocardial infarction (AMI) is still a challenge, without clear recommendations in spite the high incidence life-threatening ventricular arrhythmias, as implantable defibrillator (ICD) placement not indicated first 40 days an AMI; this timing aleatory and it owed to fact that two pivotal studies for evaluation ICDs primary prevention, MADIT II, excluded patients within three, respectively four weeks AMI. Methods: We...