A5078434434- Cervical Cancer and HPV Research
- Pregnancy and preeclampsia studies
- Maternal and fetal healthcare
- Endometriosis Research and Treatment
- Gestational Diabetes Research and Management
- Blood Coagulation and Thrombosis Mechanisms
- Uterine Myomas and Treatments
- Gynecological conditions and treatments
- Maternal and Perinatal Health Interventions
- Ectopic Pregnancy Diagnosis and Management
- Birth, Development, and Health
- COVID-19 Impact on Reproduction
- Prenatal Screening and Diagnostics
- Venous Thromboembolism Diagnosis and Management
- Ovarian cancer diagnosis and treatment
- Reproductive System and Pregnancy
- Endometrial and Cervical Cancer Treatments
- Epigenetics and DNA Methylation
- Congenital Anomalies and Fetal Surgery
- Pelvic floor disorders treatments
- Fetal and Pediatric Neurological Disorders
- Pregnancy-related medical research
- Reproductive tract infections research
- Urinary Tract Infections Management
- Pediatric Urology and Nephrology Studies
Grigore T. Popa University of Medicine and Pharmacy
2016-2025
Clinical Emergency Hospital Bucharest
2020-2025
Spitalul Clinic de Recuperare
2005-2010
(1) Background: Preeclampsia (PE) prediction in the first trimester of pregnancy is a challenge for clinicians. The aim this study was to evaluate and compare predictive performances machine learning-based models preeclampsia its subtypes. (2) Methods: This prospective case-control evaluated pregnancies that occurred women who attended tertiary maternity hospital Romania between November 2019 September 2022. patients' clinical paraclinical characteristics were included four models: decision...
(1) Background: Prenatal care providers face a continuous challenge in screening for intrauterine growth restriction (IUGR) and preeclampsia (PE). In this study, we aimed to assess compare the predictive accuracy of four machine learning algorithms predicting occurrence PE, IUGR, their associations group singleton pregnancies; (2) Methods: This observational prospective study included 210 pregnancies that underwent first trimester screenings at our institution. We computed performance...
Background and Objectives: Fetal ovarian cysts (FOCs) are a very rare pathology that can be associated with maternal-fetal neonatal complications. The aim of this study was to assess the influence ultrasound characteristics on FOC evolution therapeutic management. Materials Methods: We included cases admitted our perinatal tertiary center between August 2016 December 2022 prenatal or postnatal evaluation indicative FOC. retrospectively analyzed pre- medical records, sonographic findings,...
(1) Background: HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome is a rare life-threatening complication of preeclampsia. The aim this study was to evaluate compare the predictive performances four machine learning-based models for prediction syndrome, its subtypes according Mississippi classification; (2) Methods: This retrospective case-control evaluated pregnancies that occurred in women who attended tertiary maternity hospital Romania between January 2007 December...
(1) Background: SARS-CoV-2 infection during pregnancy could determine important maternal and fetal complications. We aimed to prospectively assess placental immunohistochemical changes, immunophenotyping alterations, outcomes in a cohort of patients with COVID-19; (2) Methods: 52 pregnant admitted tertiary maternity center between October 2020 November 2021 were segregated into two equal groups, depending on the presence infection. Blood samples, fragments umbilical cord, amniotic membranes,...
Cervical cancer is a leading cause of mortality in women. Molecular and epidemiological data have unequivocally confirmed that high-risk human papillomaviruses (HPVs) are major etiological agent this malignancy, as host epigenetic alterations induced response to viral infection. The present study evaluated the methylation status CpG islands surrounding miR-124a, miR-34b miR-203 29 cervical precursor lesions, 31 tumors 30 normal control samples, with aim identifying potential markers cancer....
Background In Romania (latitude 48°15'N to 43°40'N), vitamin D supplementation is common practice mostly in infants 0-1 year old. No published information available regarding epidemiological data on status the Romanian population for a wide age range and geographical territory. this context, we aimed evaluate seasonal variation of large population. Methods 6631 individuals from across had performed 7544 assessments (2012-2014) chain private laboratories. Vitamin (25-hydroxyvitamin D2...
(1) Background: Retinopathy of prematurity (ROP) can cause severe visual impairment or even blindness. We aimed to assess the hematological risk factors that are associated with different stages ROP in a cohort preterm newborns, and compare clinical characteristics therapeutic interventions between groups. (2) Methods: This retrospective study included 149 newborns from tertiary maternity hospital Romania January 2018 December 2018, who were segregated into: Group 1 (with ROP, n = 59...
Abstract Recently long non‐coding RNAs were identified as new factors involved in gene expression regulation. To gain insight into pattern of these related to E7 HPV18 oncogene, this study uses HeLa cell culture transfected with E7‐siRNA. Gene profile was investigated using microarray analysis. After analysing the results, we 15,387 RNA species differentially expressed E7‐siRNA‐transfected cells compared controls (fold change >2). The profiles lncRNA highlighted 731 lncRNAs and 203...
Background: The most commonly known cardiac effect of gestational diabetes mellitus (GD) in the fetus is hypertrophic cardiomyopathy, but recent studies show that it preceded by subclinical dysfunction. This study aimed to assess GD on fetal geometry and contractility two-dimensional speckle-tracking technology. Methods: We performed a prospective observational included 33 pregnant patients with 30 healthy individuals. For all fetuses, four-chamber 3 s cine-loop was recorded analyzed Fetal...
(1) Background: The prediction of cervical lesions evolution is a challenge for clinicians. prospective study aimed to determine and compare the predictive accuracy cytology, HPV genotyping, p16/Ki67 dual staining alone or in combination with personal risk factors progression, regression persistence human papillomavirus (HPV)-infected patients; (2) Methods: This included HPV-positive patients without that underwent follow-up. Descriptive statistics sensitivity analysis individual combined...
Background: Cervical cancer is among the highest-ranking types of worldwide, with human papillomavirus (HPV) as agent driving malignant process. One aspect infection’s evolution given by epigenetic modifications, mainly DNA methylation and chromatin alteration. These processes are guided several remodeling complexes, including NuRD. The purpose this study was to evaluate genome-wide binding patterns NuRD complex components (MBD2 MBD3) in presence active HPV16 E6 E7 oncogenes determine...
Background: Fetal growth restriction (FGR) refers to a condition in which fetus does not reach its genetically predetermined potential due various pathological factors of maternal or fetal origin, with long-life consequences, such as elevated blood pressure, type 2 diabetes mellitus, obesity, dyslipidemia, atherosclerosis. Aim: The purpose our research is delve into the intricate relationship between economic and social occurrence FGR. Methods: We analyzed risk previously associated FGR...
Background: Normal pregnancy and the postpartum period are characterized by thrombotic predisposition. Consequently, monitoring coagulation markers conducting risk assessments essential in preventing events that negatively impact both mother child. In medical practice, fibrinogen/fibrin degradation products (FDPs) main currently investigated pregnancy. Methods: We proteins C S, antiphospholipid antibodies (APLs), human factor V, beta-2-glycoprotein 1 or apolipoprotein H (APOH) levels to...
Background: Intrauterine adhesions (IUAs) or Asherman syndrome (AS) represent pathological conditions that affect the endometrium and significantly influence female fertility through a variety of mechanisms. This study aims to identify risk factors, explore pathophysiological mechanisms, diagnostic approaches, assess how medical background development these conditions. It also seeks associate severity with clinical outcomes, such as fertility, miscarriages, menstrual cycle disorders, using...
Background: Peripheral vein thrombosis during pregnancy poses serious diagnostic challenges due to the intertwining of its clinical symptoms with normal modifications. Methods: We analyzed and compared paraclinical test results singleton pregnant women in first six weeks postpartum who presented significant lower limb inequality. Results: Our data revealed three predictors deep (DVT): mean platelet volume (MPV), a one-unit increase MPV being associated 1.497-fold higher risk (p = 0.008);...
Background/Objectives: Molecular triage strategies for cervical lesions based on miR-124-2 and FAM19A4 are poorly studied in various populations. The aim of this prospective study was to evaluate the individual combined predictive performance these two markers prediction histological categories lesions. Methods: An miR124-2 methylation analysis performed 70 samples from patients negative intraepithelial lesion or malignancy (NILM), neoplasia (CIN)1-3 squamous carcinoma (SCC), along with...
Phyllodes tumors (PTs) of the breast are rare fibroepithelial (FETs), accounting for approximately 0.5% all tumors. The diagnostic interpretation borderline lesions often requires further investigations. We used statistical analysis to evaluate different surgical approaches, risk factors and prognosis during a five-year period, from January 2019 December 2024, women who underwent conservative surgeries benign, malignant examined total 481 tumors, with reserved final diagnosis paraffin,...