A5069283134- Cholinesterase and Neurodegenerative Diseases
- Medicinal Plants and Neuroprotection
- Nicotinic Acetylcholine Receptors Study
- Legume Nitrogen Fixing Symbiosis
- Genomics and Phylogenetic Studies
- Enzyme Structure and Function
- Tryptophan and brain disorders
- Plant-Microbe Interactions and Immunity
- Bacterial Genetics and Biotechnology
- Microbial Community Ecology and Physiology
- Essential Oils and Antimicrobial Activity
- Amino Acid Enzymes and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Nematode management and characterization studies
- RNA and protein synthesis mechanisms
- Microbial Metabolism and Applications
- Olfactory and Sensory Function Studies
- Phytochemistry and Biological Activities
- Advanced Proteomics Techniques and Applications
- Microbial Natural Products and Biosynthesis
- Microbial Metabolic Engineering and Bioproduction
- Genetics, Bioinformatics, and Biomedical Research
- Polyamine Metabolism and Applications
- Microbial metabolism and enzyme function
Alexandru Ioan Cuza University
2016-2025
Romanian Society of Nephrology
2024
Institut Charles Viollette
2022
Polytech Lille
2022
Clarkson University
2017-2021
University of Freiburg
2006-2007
Czech Academy of Sciences, Biology Centre
2007
Abstract Background Many edible plants are used in Cameroon since ancient time to control microbial infections. This study was designed at evaluating the antibacterial activities of methanol extracts ten Cameroonian vegetables against a panel twenty nine Gram negative bacteria including multi-drug resistant (MDR) strains. Methods The broth microdilution method determine Minimal Inhibitory Concentrations (MIC) and Bactericidal (MBC) studied extracts. When chloramphenicol as reference...
Piper nigrum L. (Piperaceae) is employed in traditional medicine of many countries as analgesic, antiinflammatory, anticonvulsant, antioxidant, antidepressant and cognitive-enhancing agent. This study was undertaken order to evaluate the possible anxiolytic, antioxidant properties methanolic extract fruits beta-amyloid (1–42) rat model Alzheimer’s disease. The anxiolytic- antidepressant-like effects were studied by means vivo (elevated plus-maze forced swimming tests) approaches. Also,...
This study reports on the inhibitory and bactericidal properties of a new synthetized flavonoid.Tricyclic flavonoid 1 has been synthesized through two-step reaction sequence. The antimicrobial effects were tested using minimum concentration (MIC) (MBC) assays. Also DNA fragmentation assay, fluorescence microscopy SEM used to mechanism action. Our displayed strong activity with MIC MBC values as low 0·24 μg ml(-1) against Staphylococcus aureus 3·9 Escherichia coli. Flavonoid properties,...
Abstract Background The present study was designed to investigate the antibacterial activities of methanol extracts four Cameroonian edible plants, locally used treat microbial infections, and their synergistic effects with antibiotics against a panel twenty nine Gram-negative bacteria including Multi-drug resistant (MDR) phenotypes expressing active efflux pumps. Methods broth microdilution method determine minimum inhibitory concentrations (MICs) [alone in presence pumps inhibitor (EPI)...
Background: A major issue with neurodegenerative diseases is cholinergic depletion, the development of oxidative stress, and reduction in ability to control expression genes involved regulation neurogenesis. The most widespread disease Alzheimer's (AD). Current treatments are not able improve symptoms disease. Thus, selecting or creating a safe effective drug very important. Objective: In this context, potential sweroside (Swe) regulate acetylcholinesterase (AChE) activity, malondialdehyde...
Cotinine (COT) and 6-hydroxy-L-nicotine (6HLN) are two nicotinic derivatives that possess cognitive-improving abilities antioxidant properties in different rodent models of Alzheimer’s disease (AD), eluding the side-effects nicotine (NIC), parent molecule. In current study, we evaluated impact COT 6HLN on memory deterioration, anxiety, oxidative stress scopolamine (SCOP)-induced zebrafish model AD. For this, were acutely administered by immersion to treated with SCOP before testing. The...
Abstract Ferulago angulata subsp. carduchorum (Apiaceae) is a shrub indigenous to western Iran, Turkey and Iraq. In traditional medicine, F. recommended for treating digestive pains, haemorrhoids, snake bites, ulcers as sedative. The present study analysed the possible anxiolytic, antidepressant antioxidant properties of essential oil in scopolamine‐induced rat model Alzheimer's disease. anxiolytic antidepressant‐like effects were studied using vivo (elevated plus‐maze forced swimming tests)...
Abstract We investigated the neuropharmacological effects of methanolic extract from Lactuca capensis Thunb. leaves (100 and 200 mg/kg) for 21 days on memory impairment in an Alzheimer's disease ( AD ) rat model produced by direct intraventricular delivery amyloid‐β1‐42 (Aβ1‐42). Behavioural assays such as Y‐maze radial arm maze test were used assessing performance. Aβ1‐42 decreased cognitive performance behavioural tests which ameliorated pre‐treatment with extract. Acetylcholinesterase...
Plants of the genus Markhamia have been traditionally used by different tribes in various parts West African countries, including Cameroun. tomentosa (Benth.) K. Schum. (Bignoniaceae) is as an antimalarial, anti-inflammatory, analgesic, antioxidant and anti-Alzheimer agent. The current study was undertaken order to investigate its anti-amnesic potential on scopolamine-induced cognitive impairment determine possible mechanism action. Rats were pretreated with aqueous extract (50 200 mg/kg,...