A5017160248- Genetic diversity and population structure
- Fish Ecology and Management Studies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Fish Biology and Ecology Studies
- Identification and Quantification in Food
- Plasma Applications and Diagnostics
- Genetic and phenotypic traits in livestock
- Reproductive biology and impacts on aquatic species
- Electrohydrodynamics and Fluid Dynamics
- Animal Genetics and Reproduction
- Cannabis and Cannabinoid Research
- Agriculture and Biological Studies
- Pain Mechanisms and Treatments
- Animal Behavior and Reproduction
- Forensic and Genetic Research
- Toxin Mechanisms and Immunotoxins
- Avian ecology and behavior
- Ecology and biodiversity studies
- Plant and animal studies
- Medicinal Plants and Neuroprotection
- Cholinesterase and Neurodegenerative Diseases
- Genomics and Phylogenetic Studies
- Wheat and Barley Genetics and Pathology
- Carcinogens and Genotoxicity Assessment
- Tryptophan and brain disorders
Grigore T. Popa University of Medicine and Pharmacy
2022-2025
Danube Delta National Institute for Research and Development
2017-2024
Academy of Agricultural and Forestry Sciences
2020-2021
"Ion Ionescu de la Brad" Iasi University of Life Sciences
2021
Alexandru Ioan Cuza University
2012-2018
Several hypotheses explain the prevalence of undifferentiated sex chromosomes in poikilothermic vertebrates. Turnovers change master determination gene, chromosome or system (e.g. XY to WZ). Jumping genes stay main triggers but translocate other chromosomes. Occasional recombination sex-reversed females) prevents degeneration. Recent research has uncovered conserved heteromorphic even homomorphic several clades non-avian and non-mammalian Sex sturgeons (Acipenseridae) been a long-standing...
Abstract Most vertebrates develop distinct females and males, where sex is determined by repeatedly evolved environmental or genetic triggers. Undifferentiated chromosomes large genomes have caused major knowledge gaps in amphibians. Only a single master sex-determining gene, the dmrt1 -paralogue ( dm-w ) of female-heterogametic clawed frogs Xenopus ; ZW♀/ZZ♂), known across >8740 species In this study, combining chromosome-scale female male non-model amphibian, European green toad, Bufo...
Atmospheric pressure DC-driven self-pulsing transient spark (TS) discharge operated in air and pulse-driven dielectric barrier plasma jet (PJ) helium contact with water solutions were used for inducing chemical effects solutions, the treatment of bacteria (Escherichia coli), mammalian cells (Vero line normal cells, HeLa cancerous cells), deoxyribonucleic acid (dsDNA), protein (bovine serum albumin). Two different methods solution supply TS: electrode system spray system. The both TS systems...
Abstract We investigated the neuropharmacological effects of methanolic extract from Lactuca capensis Thunb. leaves (100 and 200 mg/kg) for 21 days on memory impairment in an Alzheimer's disease ( AD ) rat model produced by direct intraventricular delivery amyloid‐β1‐42 (Aβ1‐42). Behavioural assays such as Y‐maze radial arm maze test were used assessing performance. Aβ1‐42 decreased cognitive performance behavioural tests which ameliorated pre‐treatment with extract. Acetylcholinesterase...
Background Radiation therapy, integral to pelvic tumor management, impacts over half of all cancer patients and may lead anal sphincter dysfunction due inflammatory responses chronic fibrotic remodeling in irradiated tissues. To address this, a targeted animal model has been developed investigate early post-radiotherapy toxicity evaluates the efficacy anti-fibrotic anti-inflammatory agents, Pirfenidone Meloxicam, as potential treatments against radiotherapy-induced dysfunction. Methods...
The conundrum of Cannabis sativa's applications for therapeutical purposes is set apart by the hundreds known and commercially available strains, social, cultural historical context, legalization its use medical in various jurisdictions around globe. In an era where targeted therapies are continuously being developed have become norm, it imperative to conduct standardized, controlled studies on strains currently cultivated under Good Manufacturing Practices (GMP) certification, a standard...
Abstract Chemotherapy-induced neuropathic pain (CINP), a condition with unmet treatment needs, affects over half of cancer patients treated chemotherapeutics. Researchers have recently focused on the endocannabinoid system because its critical role in regulating our bodies' most important functions, including pain. We used vitro and vivo methods to determine toxicity profile synthetic cannabinoid, JWH-182, whether it could be potentially effective for CINP alleviation. In vitro, we evaluated...
EU is the world's leading exporter of cheese and one top three suppliers processed milk.Instruments such as those European Food Feed Rapid Alert System (RASFF) play an increased role in consumer protection along global supply chains.On these premises, objective was to analyze status RASFF notifications for milk products food category, within time frame 2000 ÷2020.The majority dairy were notified by France, Germany Italy.Cheese most all (84.43%), transmitted safety hazards being: microbial...
Cancer study is among the hottest topics in plasma medicine. Differential killing of cancer cells and controllable selectivity may be achieved using exposure to generated by various atmospheric pressure discharges. In this article, we discuss possibility generating low-temperature air directly inside standard 24- 96-well cell-culture plates its subsequent use achieve selective cytotoxicity. After exposure, cell viability was assessed molecular biology tests carried out understand effect on...
Chemotherapy-induced peripheral neuropathy (CIPN) is a shared burden for 68.1% of oncological patients undergoing chemotherapy with Paclitaxel (PTX). The symptoms are intense and troublesome, reporting paresthesia, loss sensation, dysesthetic pain. While current medications focus on decreasing the symptom intensity, often ineffective, no medication yet recommended by guidelines prevention CIPN. Cannabinoids an attractive option, as their neuroprotective features have already been...
The Russian sturgeon, Acipenser gueldenstaedtii, is a critically endangered fish species. Hatcheries are operated in several countries within its natural range to produce stocking material for release into the wild and also aquaculture purposes (caviar meat production). An appropriate genetic broodstock management (plan or strategy) required avoid negative effects, e.g., admixture hybridization of genetically differing stocks loss variability due inbreeding drift. Therefore, 11 tetrasomic...
Summary Several hypotheses explain the prevalence of undifferentiated sex chromosomes in poikilothermic vertebrates. Turnovers change master determination gene, chromosome or system (e.g. XY to WZ). Jumping genes stay main triggers but translocate other chromosomes. Occasional recombination sex-reversed females) prevents degeneration. Recent research has uncovered conserved heteromorphic even homomorphic several clades non-avian and non-mammalian Sex sturgeons (Acipenseridae) been a...
Since 2000, the Food and Agriculture Organization of United Nations (FAO) has been drawing attention to increasing numerical decline Podolian cattle, which include Romanian Grey Steppe. Currently, this breed is endangered, numbering under 100 heads across territory entire country. Due its qualities rusticity, adaptability, increased resistance diseases severe climate conditions, Steppe considered a valuable genetic reserve for improving livestock production. This study aimed quantify...
The chromo-helicase-DNA binding protein (CHD) genes are widely used markers for sex determination in birds and provide a rapid low-cost method with applicability to large number of taxa. A good phylogenetic marker displays highly conserved domains slow evolution rate, proprieties that CHD seem have. This gives rise the following question: is gene reliable bird population analysis? aim this study investigate whether tool molecular phylogeny analysis within superfamily Sylvioidea. Our results...
One of the last wild populations critically endangered stellate sturgeon (Acipenser stellatus) survives in Danube River. Limited knowledge about genetic structure, ecology, and evolution this species led to poor inconsistent management decisions with an increased risk for extinction wild. Here we show results structure screening River population over 12 years timespan. Our research does not bring evidence recovery. No structuring was identified at mitochondrial level concerning spawning...
The association between chronic obstructive pulmonary disease (COPD) and metabolic syndrome (MetS) is a common one, with long-term therapeutic prognostic impact. In view of the high cardiovascular morbidity mortality, self-management contributes to decreasing risk an acute cardiac event or decompensation.
The survival of the critically endangered beluga sturgeon, Huso huso, dependsamong otherson an effective fisheries management and supportive stocking.To gather necessary knowledge on genetic diversity structure still existing wild populations, microsatellite loci from related sturgeon species were tested for their cross-species amplification ability species-specific newly isolated using 454 GS-FLX Titanium pyrosequencing.Twelve suitable polymorphic microsatellites could be identified...