A5011396524- Renin-Angiotensin System Studies
- Pain Mechanisms and Treatments
- Blood Pressure and Hypertension Studies
- Cannabis and Cannabinoid Research
- Hormonal Regulation and Hypertension
- Neuroscience and Neuropharmacology Research
- Neuroendocrine regulation and behavior
- Alzheimer's disease research and treatments
- Pharmaceutical studies and practices
- Pharmacogenetics and Drug Metabolism
- Phytochemistry and Biological Activities
- Stress Responses and Cortisol
- Pharmaceutical Practices and Patient Outcomes
- Pharmacological Effects of Natural Compounds
- Autism Spectrum Disorder Research
- Dementia and Cognitive Impairment Research
- Pharmacological Effects and Toxicity Studies
- Cholinesterase and Neurodegenerative Diseases
- Pharmacological Receptor Mechanisms and Effects
- Synthesis and biological activity
- Essential Oils and Antimicrobial Activity
- Nicotinic Acetylcholine Receptors Study
- Neurological Disorders and Treatments
- Phytochemicals and Antioxidant Activities
- Neurotransmitter Receptor Influence on Behavior
Grigore T. Popa University of Medicine and Pharmacy
2012-2024
Romanian Academy
2010-2024
Abstract In addition to its known classical roles, the renin angiotensin system (RAS) has more subtle functions which include regulation of emotional responses. Previous studies regarding anxiety related behavior RAS have showed controversial results. There is also evidence that oxidative stress accompanies II infusion, but role AT1/AT2 specific receptors not clear. The aim this study was evaluate effects central receptor blockers on state and stress. Behavioral testing included elevated...
The incidence of neurodegenerative diseases, such as Alzheimer’s disease (AD), is continuously growing worldwide, which leads to a heavy economic and societal burden. lack safe effective causal therapy in cognitive decline an aggravating factor requires investigations into the repurposing commonly used drugs. Sodium-glucose co-transporter 2 inhibitors (SGLT2i) are new efficient class hypoglycemic drugs and, due their pleiotropic effects, have indications that go beyond diabetes. There...
Abstract Chemotherapy-induced neuropathic pain (CINP), a condition with unmet treatment needs, affects over half of cancer patients treated chemotherapeutics. Researchers have recently focused on the endocannabinoid system because its critical role in regulating our bodies' most important functions, including pain. We used vitro and vivo methods to determine toxicity profile synthetic cannabinoid, JWH-182, whether it could be potentially effective for CINP alleviation. In vitro, we evaluated...
The roots of Vernonia kotschyana Sch. Bip. ex Walp. (Asteraceae) are used in Malian traditional medicine the treatment gastroduodenal ulcers and gastritis. Since oxidative stress is involved gastric ulceration, aim this study was to screen root extracts for their vitro antioxidant activity phenolic content. were extracted successively with chloroform, ethyl acetate, ethanol water. evaluated both cell-free cell-based assays. Their chemical characterization performed by Fourier transform...
In recent years, many healthcare systems, along with professionals, have provided services in a patient-centered manner, which patients are key actors the care process. Encouraging self-care creates responsible patients, but it must be practiced responsibly. This study aims to analyze tendency towards self-medication for from rural area Northeastern Romania. Data were collected using questionnaire, consisted of 25 questions, that has been developed by research team. Student's T test or...
The conundrum of Cannabis sativa's applications for therapeutical purposes is set apart by the hundreds known and commercially available strains, social, cultural historical context, legalization its use medical in various jurisdictions around globe. In an era where targeted therapies are continuously being developed have become norm, it imperative to conduct standardized, controlled studies on strains currently cultivated under Good Manufacturing Practices (GMP) certification, a standard...
Romania is considered a country with high cardiovascular risk, arterial hypertension and its complications accounting for about 60% of total deaths. The management blood pressure often involves combination both therapeutic regimens as well lifestyle changes, to which patients have be adherent. In order assess adherence professionals' recommendations, validated tools are needed. aim our study was translate, culturally adapt validate the Hill-Bone Compliance High Blood Pressure Therapy Scale...
Schiff bases and their complex combinations with metallic ions represent a class of compounds antimicrobial activity. A ligand was prepared by condensation the salicylaldehyde 2‐aminopyridine obtaining 2‐(salicylidene) aminopyridine (SB) high capacity for complexing Cu(II) ions. The new compound has been characterized physical constants (melting point, solubility, stability) chemical structure confirmed elemental, spectral (IR, UV–visible, 1 H NMR 13 C‐NMR) thermal analyses. elemental...
Manganese is a very well known neurotoxic agent. It has been mainly linked to impaired motor skills and disturbed psychomotor development. However, few aspects are about the cognitive deficits behavioral consequences of chronic manganese exposure. In this context, we report herein our findings regarding short-term spatial memory, anxiety-like behavior assessments in male Wistar rats exposed for 45 days two different doses (3 mg/kg b.w., i.p. 10 i.p.) manganese. Behavior testing (Y-maze task...
This study was designed to evaluate the spatial working memory (as studied in Y-maze) or short-term and long-term (assessed radial 8 arms-maze task), a scopolamine-induced deficits model mice, by oral administration of 2 angiotensin-converting enzyme inhibitors—captopril ramipril also effects AT1 receptor antagonist, losartan. The present article initiated as reaction clinical setting hypertensive disease, which involves lifelong antihypertensive drugs, dietary lifestyle constraints, aging,...
There is increased interest in the interactions between vascular disorders and Alzheimer?s disease (AD). While initially these were explained by fact that are both very common disorders, particularly later life, recently, possibility deficiencies might actually coexist increasingly being questioned. This review attempts to present modern aspects current reports regarding AD, renin-angiotensin system (RAS) hypertension, while also describing relevance of antihypertensive drug use acting via...