This study reports on the inhibitory and bactericidal properties of a new synthetized flavonoid.Tricyclic flavonoid 1 has been synthesized through two-step reaction sequence. The antimicrobial effects were tested using minimum concentration (MIC) (MBC) assays. Also DNA fragmentation assay, fluorescence microscopy SEM used to mechanism action. Our displayed strong activity with MIC MBC values as low 0·24 μg ml(-1) against Staphylococcus aureus 3·9 Escherichia coli. Flavonoid properties,...

The emergence of pathogenic multidrug-resistant bacteria demands new approaches in finding effective antibacterial agents. Synthetic flavonoids could be a reliable solution due to their important antimicrobial activity. We report here the potent vitro activity ClCl-flav—a novel synthetic tricyclic flavonoid. effects were tested using minimum inhibitory concentration (MIC), time kill and biofilm formation assays. Fluorescence microscopy scanning electron employed study mechanism action. MTT...

Background/Objectives: The discovery of new molecules to which bacteria have not yet developed resistance is a significant medical priority. Synthetic flavonoids are good candidates for developing antimicrobials. Our study investigates series newly synthesized tricyclic with several different substituents on the flavonoid core. Methods: By varying nature rings A and B, structure–activity relationship using microbial strains has been performed. antibacterial antifungal properties these...

The antioxidant properties of novel diiodo-substituted 3-dithiocarbamic flavanones were investigated. three frameworks that proved to be the most active ones in our previous studies selected. By varying nature substituent at para position flavanone ring B, a structure–activity relationship study on radical scavenging was performed. influence these substituents (F, Cl, Br and H) investigated against DPPH ABTS+•. results indicate presence halogen induces better than ascorbic acid BHT. highest...

A structure–activity relationship study concerning the antibacterial properties of several halogen-substituted tricyclic sulfur-containing flavonoids has been performed. The compounds have synthesized by cyclocondensation corresponding 3-dithiocarbamic flavanones under acidic conditions. influence different halogen substituents on tested against Staphylococcus aureus and Escherichia coli . Amongst N , -dialkylamino-substituted flavonoids, those having an -diethylamino moiety exhibited good...

In this paper we present several expert systems that predict the class identity of modeled compounds, based on a preprocessed spectral database. The were built using Artificial Neural Networks (ANN) and are designed to if an unknown compound has toxicological activity amphetamines (stimulant hallucinogen), or whether it is nonamphetamine. attempts circumvent laws controlling drugs abuse, new chemical structures very frequently introduced black market. They obtained by slightly modifying...

The antioxidant properties of 3-dithiocarbamic flavanones have been investigated. influence the halogen substituents on ring A and nature secondary amine from dithiocarbamic moiety accounted. results indicated that presence a substituent at C-8 position benzopyran induce better against DPPH ABTS than butylated hydroxytoluene (BHT) ascorbic acid. mentioned appears to higher stability for free radical intermediate C-3 ring. enolate is most likely be involved in activity this flavanone. It...

Abstract A facile synthesis of Pechmann dyes has been accomplished by the reaction substituted N ‐phenacyl‐4‐dimethylaminopyridinium halides with dimethyl maleate in presence DBU. Based on a related 4‐DMAP elimination product and an isolated monolactone intermediate mechanism proposed. The scope this synthetic method is determined availability α‐haloaroyl or heteroaroyl derivatives. DBU=1,8‐diazabicycloundec‐7‐ene, DMAP=4‐dimethylaminopyridine.

An addition/elimination sequence of selenium halides to pseudo-geminally bis(acetylene) substituted [2.2]paracyclophanes leads new bridges with an endo - exo -diene substructure. The reactions have been found be sensitive the substitution ethynyl group. formation dienes a zig-zag configuration is related that observed for non-conjugated cyclic diynes medium ring size.

Abstract The reaction of 10‐azidoacetyl‐10 H ‐phenothiazine with olefinic dipolarophiles depends on the temperature. In refluxing toluene, a mixture enamine and aziridine is formed in 3:1 ratio. mechanism appears to involve Michael‐type addition nucleophilic N 1 azide atom double bond. chloroform, cycloaddition takes place formation 4,5‐dihydro‐1,2,3‐triazole. heating dihydrotriazoles toluene accompanied by nitrogen elimination leading 1:3 J. Heterocyclic Chem., 2011.

A direct and highly selective synthesis of octahydropyrrolo[2,1,5-cd]indolizin-6-one derivatives has been accomplished by a double dipolar cycloaddition olefinic dipolarophiles to p-(di­methylamino)pyridinium ylides.

Abstract Two racemic tetrathiafulvalene‐[2.2]paracyclophane electron donors EDT‐TTF‐[2.2]paracyclophane 1 and (COOMe) 2 ‐TTF‐[2.2]paracyclophane have been synthesized via the phosphite mediated cross coupling strategy. Chiral HPLC allowed optical resolution of ( R P ) S enantiomers for both compounds. Solid‐state structures )‐ rac determined by single crystal X‐ray analysis. Intermolecular π‐π S•••S interactions are disclosed in packing. Single analysis combined with experimental theoretical...

Mono-, pseudo-gem, and pseudo-para ethynylcyclophanes bis(azides) have been employed as addition partners in CuAAC reactions to design build complex extended molecular scaffolds. The reactivity of the resulting triazoles was investigated under photochemical conditions. A variety newly substituted [2.2]paracyclophanes were identified; deazotization pseudo-gem adducts provided indolophane derivatives. An intramolecular stabilization effect observed case rearrangement from a adduct pseudo-ortho...

Infections caused by Candida are very difficult to treat due increasing antifungal resistance. Recent studies showed that patients with infections resistant fluconazole have few treatment options. Therefore, finding new efficient agents is a matter of medical high priority. The aim this study was explore the potential BrCl-flav-a representative class synthetic flavonoids bromine as halogen substituent at benzopyran core against four clinical strains. Determination minimum inhibitory...

Several new di- and tetracarboxylic [2.2]paracyclophane derivatives were obtained via Suzuki coupling between the appropriately brominated [2.2]paracyclophanes 4-(methoxycarbonyl)phenylboronic acid. The reaction of one these products, namely pp-bis(4-carboxyphenyl)[2.2]paracylophane (12), with zinc nitrate afforded a 2D coordination polymer comprising zinc-carboxylate paddlewheel clusters linked together by cyclophane cores. center is five-coordinated in square-pyramidal geometry, DMF oxygen...

Methicillin-resistant

The antioxidant properties of some 3-dithiocarbamic flavanones were investigated. Based on a previous study, we selected three frameworks that proved to be the most active ones. By varying nature substituent at para-position flavanone ring B, structure–activity relationship study radical scavenging activities was performed. influence these substituents (H, F, Cl, Br and I) evaluated in relation DPPH, ABTS FRAP. results indicated presence halogen induced better than ascorbic acid BHT. found...