A5078532624- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthesis and biological activity
- Heme Oxygenase-1 and Carbon Monoxide
- Cancer, Hypoxia, and Metabolism
- Prostate Cancer Treatment and Research
- Synthesis of Organic Compounds
- Synthesis of heterocyclic compounds
- Synthesis and Reactions of Organic Compounds
- Synthesis and Biological Evaluation
- Synthesis and Characterization of Heterocyclic Compounds
- Multicomponent Synthesis of Heterocycles
- Crystallography and molecular interactions
- Click Chemistry and Applications
- Hemoglobin structure and function
- Metal-Organic Frameworks: Synthesis and Applications
- Molecular Sensors and Ion Detection
- Cannabis and Cannabinoid Research
- Chemical Reaction Mechanisms
- Luminescence and Fluorescent Materials
- Magnetism in coordination complexes
- Metal complexes synthesis and properties
- Organic Chemistry Cycloaddition Reactions
- Chemical Synthesis and Analysis
- Alcohol Consumption and Health Effects
Institutul de Chimie Macromoleculară Petru Poni
2014-2024
Institute of Macromolecular Chemistry
2013-2015
Queen's University
2007-2013
Transylvania University of Brașov
1999-2008
National Academies of Sciences, Engineering, and Medicine
2006
National Research Council Canada
1999-2005
Biotechnology Research Institute
2005
Gheorghe Asachi Technical University of Iași
1999
Heme oxygenase-1 (HO-1), a member of the heat shock protein family, plays key role as sensor and regulator oxidative stress. Herein, we identify HO-1 biomarker potential therapeutic target for advanced prostate cancer (PCA). Immunohistochemical analysis tissue using progression microarray from patients with localized PCA across several stages disease revealed significant elevation expression in epithelial cells, but not surrounding stromal hormone-refractory (HRPCA) compared...
A series of 1‐azolyl‐4‐phenyl‐2‐butanones was designed and synthesized for the inhibition heme oxygenases (heme oxygenase‐1 oxygenase‐2). The replacement imidazole by other azoles led to discovery novel 1 H ‐1,2,4‐triazole‐ ‐tetrazole‐based inhibitors equipotent a lead imidazole‐based inhibitor. featuring 2 ‐tetrazole or ‐1,2,3‐triazole as pharmacophore were less potent. Monosubstitution at position 4(5), identical disubstitution positions 4 5 variety electron‐withdrawing electron‐donating,...
Abstract Previous studies by our research group have been concerned with the design of selective inhibitors heme oxygenases (HO‐1 and HO‐2). The majority these were based on a four‐carbon linkage an azole, usually imidazole, aromatic moiety. In present study, we designed synthesized series inhibition candidates containing shorter between groups, specifically, 1‐aryl‐2‐(1 H ‐imidazol‐1‐yl/1 ‐1,2,4‐triazol‐1‐yl)ethanones their derivatives. As regards HO‐1 inhibition, moieties yielding best...
Abstract Several α‐(1 H ‐imidazol‐1‐yl)‐ω‐phenylalkanes were synthesized and evaluated as novel inhibitors of heme oxygenase (HO). These compounds found to be potent selective for the stress‐induced isozyme HO‐1, showing mostly weak activity toward constitutive HO‐2. The introduction an oxygen atom in alkyl linker produced analogues with decreased potency whereas presence a sulfur gave rise greater HO‐1 than carbon‐containing analogues. most studied contained five‐atom between imidazolyl...
Abstract A series of (1‐substituted aryl)‐3‐(1 H ‐imidazol‐1‐yl)‐1‐propanones was synthesized through the N ‐alkylation imidazole with 3‐dimethylamino‐1‐(substituted aryl)‐1‐propanone hydrochlorides (ketonic Mannich bases). second 1 ‐substituted imidazoles obtained by reduction carbonyl function imidazole–ketones in previous means NaBH 4 . All compounds were evaluated for antifungal activity against 16 strains Candida , and 3‐(1 ‐imidazol‐1‐yl)‐1‐(4‐biphenylyl)‐1‐propanone emerged as a...
Abstract A series of compounds structurally related to astemizole were designed and synthesized with the goal determining their anti‐ Plasmodium activity. Several modifications structure, namely removal 4‐fluorobenzyl and/or 4‐methoxyphenethyl moieties, substitution benzene ring benzimidazole scaffold, replacement fluorine atom in group, variation 4‐aminopiperidine moiety, explored. In vitro evaluation activity these using ItG strain showed that some its similar derivatives have IC 50 values...
The advances in the chemistry of Mannich bases electron-rich, monocyclic five-membered heterocycles with one heteroatom thiophene and furan are reviewed. aminomethylation these along reactivity applications their summarized. Keywords: Aminomethylation, mannich reaction, bases, thiophene, furan, drug design
Compounds with a pyrazoline scaffold are useful as sensors for fluorescence detection of different types analytes. Recovery pyrazoline-based sensor view to use it recurrently would be more facile when the sensing molecule is attached solid support. A reaction sequence has been designed synthesize two benzaldehyde–pyrazoline hybrids examples hitherto unknown type compounds employed potential derivatization polymers containing primary amino groups through azomethine formation. All...
A dual channel fluorescence system that combines the optical properties of silicon quantum dots-polysilane nanocomposites with those 2-(4-chlorophenyl)-6-(thiophen-2-yl)pyridine, a fluorescent cytotoxic agent, is presented.The capable to alternatively trigger emission signals at two different wavelengths by excitation single wavelength.For this purpose highly stable colloidal dispersion nanocomposite prepared one-pot synthetic method using microwave-activated Wurtz coupling...
Heme oxygenases (HOs) catalyze the degradation of heme to biliverdin, carbon monoxide (CO), and free iron. The two major isoforms, HO-1 (inducible) HO-2 (constitutive), are involved in a variety physiological functions, including inflammation, apoptosis, neuromodulation, vascular regulation. Major tools used exploring these actions have been metalloporphyrin analogs that inhibit HOs. However, limited by their lack selectivity; they affect other heme-dependent enzymes, such as cytochromes...