A5061192156- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Crystallography and molecular interactions
- Synthesis and biological activity
- biodegradable polymer synthesis and properties
- Metal complexes synthesis and properties
- Silicone and Siloxane Chemistry
- Conducting polymers and applications
- Natural product bioactivities and synthesis
- Plant biochemistry and biosynthesis
- Synthesis and Biological Evaluation
- Organic Electronics and Photovoltaics
- Drug Solubulity and Delivery Systems
- Enzyme Catalysis and Immobilization
- Click Chemistry and Applications
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Reactivity of Heterocycles
- Enzyme-mediated dye degradation
- Luminescence and Fluorescent Materials
- Hydrogels: synthesis, properties, applications
- Synthesis and properties of polymers
- Organic Light-Emitting Diodes Research
- Marine Biology and Environmental Chemistry
- Biochemical and Molecular Research
- Biopolymer Synthesis and Applications
Institutul de Chimie Macromoleculară Petru Poni
2013-2024
Institute of Macromolecular Chemistry
2014-2024
Czech Academy of Sciences, Institute of Macromolecular Chemistry
2024
Romanian Academy
2011-2022
Gheorghe Asachi Technical University of Iași
2015
Alexandru Ioan Cuza University
2010
As ribonucleotide reductase (RNR) plays a crucial role in nucleic acid metabolism, it is an important target for anticancer therapy. The thiosemicarbazone Triapine efficient R2 inhibitor, which has entered ∼20 clinical trials. Thiosemicarbazones are supposed to exert their biological effects through effectively binding transition-metal ions. In this study, six iminodiacetate–thiosemicarbazones able form complexes, as well dicopper(II) were synthesized and fully characterized by analytical,...
Background: Magnolol (MG) and honokiol (HK) are bioactive compounds extracted from Magnolia obovata Officinalis trees with significant pharmacological properties, including antioxidant antibacterial activity. However, their poor water solubility low bioavailability limit the therapeutic potential. Methods: To address these limitations, this study aims to develop MG HK formulations by co-electrospinning using custom-synthesized β-cyclodextrin-oligolactide (β-CDLA) derivatives. MALDI MS NMR...
The incorporation of non-native chemical elements, such as silicon, into drug molecules has gained significant attention a strategy to broaden the space in medicinal chemistry and develop novel...
Recently, the development of new materials with desired characteristics for functional tissue engineering, ensuring architecture and supporting cellular growth, has gained significant attention. Hydrogels, which possess similar properties to natural matrixes, being able repair or replace biological tissues support healing process through proliferation viability, are a challenge when designing scaffolds. This paper provides insights into hydrogel-based polymeric blends (hydroxypropyl...
The extensive biochemical research of multiple types cancer has revealed important enzymatic signaling pathways responsible for tumor occurrence and progression, thus compelling the need discovery new means with which to block these cascades. phosphoinositide 3-kinase/ protein kinase B (PI3K/AKT) pathway, plays an role in maintaining relevant cellular functions, exhibits various alterations common human cancers, representing a suitable target treatment. Molecules bearing 1,2,4-triazole...
A series of novel S-substituted 1H-3-R-5-mercapto-1,2,4-triazoles, obtained by docking based virtual screening (DBVS) a previous constructed compound library, were synthesized and evaluated for their biological activities on colorectal cancer cell line, HT-29. Among all compounds, TZ55.7, which was retained as possible PDK1 (phospholipid-dependent kinase 1) inhibitor, exhibited the most significant cytotoxic activity against HT-29 tumor line. The same alongside other two, TZ53.7 TZ3a.7, led...
Pentacyclic triterpenes, such as betulinic, ursolic, and oleanolic acids are efficient selective anticancer agents whose underlying mechanisms of action have been widely investigated. The introduction N-bearing heterocycles (e.g., triazoles) into the structures natural compounds (particularly pentacyclic triterpenes) has yielded semisynthetic derivatives with increased antiproliferative potential opposed to unmodified starting compounds. In this work, we report synthesis biological...
Betulinic acid is a naturally occurring pentacyclic triterpene belonging to the lupane-group that exhibits wide range of pharmacological activities. BA derivatives are continuously being researched due their improved anticancer efficacy and bioavailability. The current research was conducted in order determine antiproliferative potential three synthesized fatty esters using palmitic, stearic butyric acids liposomal nanoformulations. cytotoxic (Pal-BA, St-BA, But-BA) respective formulations...
Nuclear magnetic resonance (NMR) metabolomics is currently popular enough to attract both specialized and non-specialized NMR groups involving analytical trained personnel newcomers, including undergraduate students. Recent interlaboratory studies performed by established demonstrated high reproducibility of the state-of-the-art equipment SOPs. There is, however, no assessment when mixing experts newcomers. An quantitation was using two instruments belonging different laboratories several...
Cyclodextrins have previously been proven to be active in the catalysis of cyclic ester ring-opening reactions, hypothetically a similar way lipase-catalyzed reactions. However, they act remains unclear. Here, we focus on β-cyclodextrin's involvement synthesis and characterization β-cyclodextrin-oligocaprolactone (CDCL) products obtained via organo-catalyzed ε-caprolactone. Previously, bulk or supercritical carbon dioxide polymerizations has led inhomogeneous products. Our approach consists...
Based on a theoretical model and an experimental methodology for defining the friction torque lubricated conditions in modified thrust ball bearing having only three balls, authors experimentally investigated influence of lubricant parameter Λ mixed IVR (isoviscous rigid) EHL (elastohydrodynamic) lubrication conditions. The experiments were conducted using diameters 3 mm, 3.97 mm 6.35 loaded at 0.125 N, 0.400 N 0.633 N. Two oils viscosity 0.08 Pa·s 0.05 used rotational speed was varied range...
Natural deep eutectic solvents (NADES)-hydroxypropyl cellulose (HPC) self-assembled gels with potential for pharmaceutical applications are prepared. FT-IR, 1HNMR, DSC, TGA and rheology measurements revealed that hydrogen bond acceptor–hydrogen donor interactions, concentration of NADES the water content influence significantly physico-chemical characteristics studied gel systems. HPC-NADES compositions have thermal stabilities lower than HPC higher components. Thermal transitions reveal...
A new siloxane diamine, 1,3-bis(amino-phenylene-ester-methylene)tetramethyldisiloxane (1), was obtained by a two-step procedure and used to prepare series of Schiff bases (2–5), reaction with different carbonylic compounds: salicylaldehyde, 3,5-dibromosalicylaldehyde, 5-chlorosalicylaldehyde 3,5-di-tert-butyl-2-hydroxybenzaldehyde. All compounds, separated in crystalline form, were characterised spectral (FTIR, UV–vis NMR) analysis as well single-crystal X-ray diffraction. In these...
Herein, we report the synthesis of inclusion complexes (ICs) based on 3,4-ethylenedioxythiophene (EDOT) with permethylated β-cyclodextrins (TMe-βCD) and γ-cyclodextrins (TMe-γCD) host molecules. To prove such ICs, molecular docking simulation, UV-vis titrations in water, 1H-NMR, H-H ROESY, as well matrix-assisted laser desorption ionization mass spectroscopy (MALDI TOF MS) thermogravimetric analysis (TGA) were carried out each EDOT∙TMe-βCD EDOT∙TMe-γCD samples. The results computational...
New squalene/BPEI conjugates, acting as efficient gene carriers, were included in the 3D matrix, yielding tunable DNA release and long-term bioavailability.
Cancer, in all its types and manifestations, remains one of the most frequent causes death worldwide; an important number anticancer drugs have been developed from plants, fungi animals, starting with natural compounds that were later derivatized order to achieve optimized pharmacokinetic/pharmacological profile. Betulinic acid is a pentacyclic triterpenic compound was identified as agent whose main advantage consists selective activity, which ensures almost total lack cytotoxic side...