A5050827290- Natural product bioactivities and synthesis
- Plant biochemistry and biosynthesis
- Essential Oils and Antimicrobial Activity
- Phytochemistry and Biological Activities
- Phytochemical compounds biological activities
- Computational Drug Discovery Methods
- Nanoparticle-Based Drug Delivery
- Pharmacological Effects of Natural Compounds
- Biological Activity of Diterpenoids and Biflavonoids
- Toxin Mechanisms and Immunotoxins
- Synthesis and biological activity
- Phytochemicals and Antioxidant Activities
- Bioactive Compounds and Antitumor Agents
- Click Chemistry and Applications
- Nanoparticles: synthesis and applications
- Medicinal Plant Extracts Effects
- Biochemical and Molecular Research
- Mycobacterium research and diagnosis
- Cancer Research and Treatments
- Sesquiterpenes and Asteraceae Studies
- RNA Interference and Gene Delivery
- Bioactive natural compounds
- ATP Synthase and ATPases Research
- SARS-CoV-2 and COVID-19 Research
- Tannin, Tannase and Anticancer Activities
Victor Babeș University of Medicine and Pharmacy Timișoara
2015-2024
Romanian Academy
2017
Purpose: Breast cancer presents one of the highest rates prevalence around world. Despite this, current breast therapy is characterized by significant side effects and high risk recurrence. The present work aimed to develop a new therapeutic strategy that may improve developing heat-sensitive liposomal nano-platform suitable incorporate both anti-tumor betulinic acid (BA) compound magnetic iron nanoparticles (MIONPs), in order address remote drug release hyperthermia-inducing features. To...
The investigation aimed to study the in vitro and silico antioxidant properties of Melissa officinalis subsp. essential oil (MOEO). chemical composition MOEO was determined using GC–MS analysis. Among 36 compounds identified MOEO, main were beta-cubebene (27.66%), beta-caryophyllene (27.41%), alpha-cadinene (4.72%), caryophyllene oxide (4.09%), alpha-cadinol (4.07%), respectively. In have been studied 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) 2,2-diphenyl-1-picrylhydrazyl...
Gold nanoparticles are currently investigated as theranostics tools in cancer therapy due to their proper biocompatibility and increased efficacy related the ease customize surface properties conjugate other molecules. Betulin, [lup-20(29)-ene-3β, 28-diol], is a pentacyclic triterpene that has raised scientific interest its antiproliferative effect on several types. Herein we described synthesis of modified betulin-conjugated gold using slightly Turkevich method. Transmission electron...
Breast cancer is the most frequently diagnosed malignant pathology, representing primary cause of death in women. Natural products are an appealing strategy to limit progression disease. Targeting angiogenesis breast may positively impact on poor prognosis cancer. As source natural compounds, we investigated leaves Melissa officinalis L. (MO), known as lemon balm, aromatic plant that spontaneously grows South and Western areas Romania, being traditionally recommended anxiolytic,...
This study was conducted to identify the volatile compounds of Mentha × smithiana essential oil (MSEO) and evaluate its antioxidant antibacterial potential. The (EO) content assessed by gas chromatography–mass spectrometry (GC-MS). Carvone (55.71%), limonene (18.83%), trans-carveol (3.54%), cis-carveol (2.72%), beta-bourbonene (1.94%), caryophyllene oxide (1.59%) were main identified compounds. MSEO displayed broad-spectrum effects also found be most effective antifungal agent against...
The research aimed to investigate the chemical composition and antioxidant antibacterial potential of essential oil (EO) isolated from aerial parts (flowers, leaves, stems) Ruta graveolens L., growing in western Romania. L. (RGEO) was by steam distillation (0.29% v/w), content assessed gas chromatography-mass spectrometry (GC-MS). Findings revealed that 2-Undecanone (76.19%) 2-Nonanone (7.83%) followed 2-Undecanol (1.85%) 2-Tridecanone (1.42%) are main detected compounds oil. RGEO exerted...
Betulinic acid (BA) was demonstrated to be a very promising anticancer agent against various tumor cell lines such as breast, colon, lung, and brain. Despite its strong cytotoxic effect, betulinic exhibits low water solubility, feature that is reflected in poor bioavailability. To overcome these drawbacks, numerous strategies were conducted improve physicochemical pharmacokinetic profile, among which cocrystalization emerged approach. Thus, our work consisted obtaining slowly grown...
Cancer remains a leading cause of death worldwide and, even though several advances have been made in terms specific treatment, the late-stage detection and associated side effects conventional drugs sustain search for better treatment alternatives. Probiotics are live microorganisms that proven to possess numerous health benefits human hosts, including anticancer effects. In present study, vitro effect association two probiotic strains (PBT), Lactobacillus sporogenes Clostridium butyricum,...
The extensive biochemical research of multiple types cancer has revealed important enzymatic signaling pathways responsible for tumor occurrence and progression, thus compelling the need discovery new means with which to block these cascades. phosphoinositide 3-kinase/ protein kinase B (PI3K/AKT) pathway, plays an role in maintaining relevant cellular functions, exhibits various alterations common human cancers, representing a suitable target treatment. Molecules bearing 1,2,4-triazole...
A series of novel S-substituted 1H-3-R-5-mercapto-1,2,4-triazoles, obtained by docking based virtual screening (DBVS) a previous constructed compound library, were synthesized and evaluated for their biological activities on colorectal cancer cell line, HT-29. Among all compounds, TZ55.7, which was retained as possible PDK1 (phospholipid-dependent kinase 1) inhibitor, exhibited the most significant cytotoxic activity against HT-29 tumor line. The same alongside other two, TZ53.7 TZ3a.7, led...