Ephedra alata Decne. belongs to the Ephedraceae family. It is a species of that grows mostly in desert. Today, main importance medical field due presence alkaloids derived from phenyl-alanine, which act on sympathetic nervous system as sympathomimetic. The aim this study was conduct phytochemical characterization hydroalcoholic extract aerial part Decne., indigenous Tunis, involves total phenolic content, individual and antioxidant activity well biological screening for evaluation...

Apigenin (4′,5,7-trihydroxyflavone) (Api) is an important component of the human diet, being distributed in a wide number fruits, vegetables and herbs with most sources represented by chamomile, celery, celeriac parsley. This study was designed for comprehensive evaluation Api as antiproliferative, proapoptotic, antiangiogenic immunomodulatory phytocompound. In set experimental conditions, presents antiproliferative activity against A375 melanoma cell line, G2/M arrest cycle cytotoxic events...

Background and Objectives: Nowadays, the development of enabled pharmaceutical nanoparticles solid lipid type is continuously growing, because they have potential to be used for targeted drug release leading an increased effect chemotherapy, being in lung cancer nano-diagnosis nano-therapy. The current study reports preliminary results obtained regarding biological a new nano-enabled formulation terms its cytotoxic biosafety profile. Materials Methods: formulations consist (SLN) via...

Purpose: Breast cancer presents one of the highest rates prevalence around world. Despite this, current breast therapy is characterized by significant side effects and high risk recurrence. The present work aimed to develop a new therapeutic strategy that may improve developing heat-sensitive liposomal nano-platform suitable incorporate both anti-tumor betulinic acid (BA) compound magnetic iron nanoparticles (MIONPs), in order address remote drug release hyperthermia-inducing features. To...

Gold nanoparticles are currently investigated as theranostics tools in cancer therapy due to their proper biocompatibility and increased efficacy related the ease customize surface properties conjugate other molecules. Betulin, [lup-20(29)-ene-3β, 28-diol], is a pentacyclic triterpene that has raised scientific interest its antiproliferative effect on several types. Herein we described synthesis of modified betulin-conjugated gold using slightly Turkevich method. Transmission electron...

Breast cancer is the most frequently diagnosed malignant pathology, representing primary cause of death in women. Natural products are an appealing strategy to limit progression disease. Targeting angiogenesis breast may positively impact on poor prognosis cancer. As source natural compounds, we investigated leaves Melissa officinalis L. (MO), known as lemon balm, aromatic plant that spontaneously grows South and Western areas Romania, being traditionally recommended anxiolytic,...

Iron oxide nanoparticles were synthesized starting from two aqueous extracts based on Artemisia absinthium L. leaf and stems, employing a simplest, eco-friendliness low toxicity method-green synthesis. The characterized by powder X-ray diffraction (XRD), Fourier transformed infrared spectroscopy (FT-IR), fluorescence analysis (XRF), thermal (TG/DSC), scanning electron microscopy (SEM). Lack of magnetic properties the reddish-brown color all samples confirms presence hematite as majority...

The high-speed development of nanotechnology industry has fueled a plethora engineered nanoparticles (NPs) and NP-based consumer products, further leading to massive uncontrolled human exposure. In this regard, the researches addressing safety assessment NPs should be re-approached from perspective test parameters variety, closely simulating daily life scenarios. Therefore, present study adopts complex in vitro models establish profile Fe3O4 NPs, by using 2D 3D epidermis under both standard...

Melissa officinalis L. has attracted an increased interest in recent years due to its multiple pharmacological effects. This study aimed compare two M. ethanolic extracts, obtained from leaves and stems, with regard their antioxidant activity, total phenolic content, cytotoxic extracts showed a very good activity the DPPH test, correlated content phenols: higher case of extract (32.76 mg GAE/g) lower for stems (8.4 GAE/g). The lemon balm exerted effect on breast cancer cells (MDA‐MB‐231)...

Oenothera biennis L. (OB), also commonly known as evening primrose, belongs to the Onagraceae family and has best studied biological activity of all members in family. In therapy, most frequently used type extracts are from aerial part, which fatty oils obtained seeds have a wide range medicinal properties. The aim this study was evaluate phytochemical composition OB hydroalcoholic extract provide directions for antimicrobial effect, antiproliferative pro-apoptotic potential against A375...

Rutin (Rut) is a natural flavonol, well-known for its broad-spectrum of therapeutic effects, including antioxidant and antitumoral activities; still, it has reduced clinical outcome due to limited solubility in aqueous solutions. To overcome this drawback, study proposes novel formulation rutin as proniosomal gel cutaneous applications. The was prepared by coacervation phase-separation method complies with the standard requirements terms particle size (140.5 ± 2.56 nm), zeta potential...

Background Objectives: The neoplastic process remains a major health problem facing humanity. Although there are currently different therapeutic options, they raise multitude of shortcomings related to the toxic effects associated with their administration. Methotrexate (Met) and Cetuximab (Cet) two basic chemotherapeutics used in cancer practice, but notwithstanding despite many years use, mechanisms by which side-effects occur not yet fully understood. Thus, present study focused on vitro...

Satureja hortensis L. presents an increased interest due to its chemical composition, abundant in monoterpenes, aglyconic and glycosylates flavonoids, phenolic acids, leading important biological activity. The present study compared the activity of volatile oil (VO) total hydro-alcoholic extract (TE) terms of: i) antioxidant activity; ii) antimicrobial iii) viability, migration proliferation on two healthy cell lines (keratinocytes-HaCaT fibroblasts-1BR3) melanoma (human-A375 murine-B164A5)....

Betulinic acid (BA) was demonstrated to be a very promising anticancer agent against various tumor cell lines such as breast, colon, lung, and brain. Despite its strong cytotoxic effect, betulinic exhibits low water solubility, feature that is reflected in poor bioavailability. To overcome these drawbacks, numerous strategies were conducted improve physicochemical pharmacokinetic profile, among which cocrystalization emerged approach. Thus, our work consisted obtaining slowly grown...

The current study presents the effect of naked Fe3O4@Carbon nanoparticles obtained by combustion method on primary human gingival fibroblasts (HGFs) and keratinocytes (PGKs)—relevant cell lines buccal oral mucosa. In this regard, objectives were as follows: (i) development via characterization nanosized magnetite particles with carbon their surface, (ii) biocompatibility assessment magnetic HGF PGK (iii) evaluation possible irritative reaction highly vascularized chorioallantoic membrane a...

Orthodontic mini-implant failure is a debatable subject in clinical practice. However, the most important parameter to evaluate success rate of primary stability, which mainly influenced by cortical bone thickness (CBT) and insertion angle. Three-dimensional finite element models maxilla were created custom-made, self-drilling, tapered was designed. For pull-out test, 12 simulations performed, sequentially increasing (1, 1.5 2 mm) angle (30°, 60°, 90°, 120°). force analysis, 24 performed...

Magnetic iron oxide nanoparticles are the most desired nanomaterials for biomedical applications due to their unique physiochemical properties. A facile single-step process preparation of a highly stable and biocompatible magnetic colloidal suspension based on citric-acid-coated used as an effective heating source hyperthermia treatment cancer cells is presented. The physicochemical analysis revealed that had z-average diameter 72.7 nm at 25 °C with polydispersity index 0.179 zeta potential...

The present study reports the successful synthesis of biocompatible magnetic iron oxide nanoparticles (MNPs) by an ecofriendly single step method, using two ethanolic extracts based on leaves Camellia sinensis L. and Ocimum basilicum effect both green raw materials as reducing capping agents was taken into account for development MNPs, well reaction temperature (25 °C 80 °C). biological MNPs obtained from extract (Cs 25, Cs 80) compared with that (Ob Ob 80), morphologically different lung...

Itraconazole is an antifungal agent included in the triazole pharmacological classification that belongs to BCS class II, characterized by a low solubility aqueous medium (of 1 ng/mL, at neutral pH), which frequently translated oral bioavailability but with high permeability. In this sense, it necessary find solutions increase/improve of itraconazole environment. The main purpose study preparation and analysis five different guest–host inclusion complexes containing intraconazole. Initially,...

In vitro alternative therapy of human epidermoid squamous carcinoma (A431) by superparamagnetic hyperthermia (SPMHT) using Fe3O4 (magnetite) nanoparticles (SPIONs) with an average diameter 15.8 nm, bioconjugated hydroxypropyl gamma-cyclodextrins (HP-γ-CDs) means polyacrylic acid (PAA) biopolymer, is presented in this paper. The was carried out at a temperature 43 °C for 30 min the concentrations ferrimagnetic from nanobioconjugates 1, 5, and 10 mg/mL cell suspension, which were previously...

The link between melanoma development and the use of oral combined contraceptives is not fully elucidated, data concerning this issue are scarce controversial. In present study, we show that components contraceptives, ethinylestradiol (EE), levonorgestrel (LNG), their combination (EE + LNG) ± UVB (ultraviolet B radiation) induced differential effects on healthy (human keratinocytes, fibroblasts, primary epidermal melanocytes, murine epidermis cells) cells (human-A375 murine-B164A5), as...

Magnetic iron oxide nanoparticles (MIONPs) were placed in the spotlight lately due to their excellent biocompatibility and possibility tailor magnetic properties making them useful a plethora of bioapplications, including resonance imaging targeted nanoplatforms for anticancer drugs delivery. The aim present study consisted achieving toxicological profile biocompatible colloidal suspension coated with double layer oleic acid (Fe₃O₄ @OA) obtained by combustion method performing vitro (on...

Increased sugar consumption and unhealthy dietary patterns are key drivers of many preventable diseases that result in disability death worldwide. However, health awareness has increased over the past decades creating a massive on-going demand for new low/non-caloric natural sweeteners have high potential safer than artificial ones. The current study aims to investigate nutritional properties, vitro toxicological profile, total/individual polyphenols content, antioxidant, anti-cariogenic,...

Albendazole is a benzimidazole derivative with documented antitumor activity and low toxicity to healthy cells. The major disadvantage in terms of clinical use its aqueous solubility which limits bioavailability. was incorporated into stable homogeneous polyurethane structures the aim obtaining an improved drug delivery system model. Spectral thermal analysis used investigate encapsulation process confirmed presence albendazole inside nanoparticles. vitro anticancer properties encapsulated...