A5045187803- Oral microbiology and periodontitis research
- Orthodontics and Dentofacial Orthopedics
- Dental materials and restorations
- Dental Implant Techniques and Outcomes
- Dental Health and Care Utilization
- Dental Radiography and Imaging
- Digital Imaging in Medicine
- dental development and anomalies
- Dental Erosion and Treatment
- Dental Anxiety and Anesthesia Techniques
- Dental Research and COVID-19
- Dental Trauma and Treatments
- Vitamin D Research Studies
- Endodontics and Root Canal Treatments
- Temporomandibular Joint Disorders
- Medical and Biological Sciences
- Reconstructive Surgery and Microvascular Techniques
- Oral Health Pathology and Treatment
- Bone Tissue Engineering Materials
- Essential Oils and Antimicrobial Activity
- Botulinum Toxin and Related Neurological Disorders
- Occupational health in dentistry
- Medicinal Plant Extracts Effects
- Oral health in cancer treatment
- Natural product bioactivities and synthesis
Victor Babeș University of Medicine and Pharmacy Timișoara
2016-2025
Lung cancer (LC) represents one of the most prevalent health issues globally and is a leading cause tumor-related mortality. Despite being attractive compounds plant origin due to its numerous biological properties, therapeutic applications rutin (RUT) are limited by disadvantageous pharmacokinetics. Thus, present study aimed evaluate in vitro application two RUT fatty acids bioconjugates, oleate (RUT-O) linoleate (RUT-L), as potential improved RUT-based chemotherapeutics non-small cell lung...
Over the past several decades, dental health products containing fluoride have been widely employed to mitigate tooth decay and promote oral hygiene. However, concerns regarding potential toxicological repercussions of exposure incited continuous scientific inquiry. The current study investigated cytotoxicity sodium (NaF) xylitol (Xyl), both individually in combination, utilizing human keratinocyte (HaCaT) osteosarcoma (SAOS-2) cell lines. In HaCaT cells, NaF decreased proliferation a...
Chlorhexidine (CHX) represents one of the most commonly used antiseptics in dentistry and other medical–pharmaceutical fields due to its broad-spectrum antimicrobial activity. However, potential toxic events arising from common use practice has become a subject increasing concern. Thus, present study was designed investigate toxicity CHX digluconate at concentrations covering antibacterial properties (0.0002–0.2%) HGF primary gingival fibroblasts, HaCaT immortalized human keratinocytes, JB6...
Introduction: The use of autologous dentin particles for augmenting the post-extraction socket and bone defects in alveolar ridge promotes rapid healing triggers a positive response from covering soft tissue, leading to an immediate attraction osteogenic stabilizing cells. Dentin possesses various qualities that facilitate creation high-quality bone. Based on clinical results investigating ankylosed teeth, grinding machine has been developed, introducing procedure which freshly extracted...
In young age, oral health is strongly influenced by the primary caregivers’ attitude towards health. Parental factors such as socioeconomic status, education level, and dental anxiety of parent may play a role in their knowledge about hygiene practices. Aim objectives: The objective this paper to identify gaps parental regarding children's highlight influence that variables parent's level education, fear dentist, or even gender have on caries, tooth eruption habits. Material methods: present...
Background Objectives: The neoplastic process remains a major health problem facing humanity. Although there are currently different therapeutic options, they raise multitude of shortcomings related to the toxic effects associated with their administration. Methotrexate (Met) and Cetuximab (Cet) two basic chemotherapeutics used in cancer practice, but notwithstanding despite many years use, mechanisms by which side-effects occur not yet fully understood. Thus, present study focused on vitro...
The current study presents the effect of naked Fe3O4@Carbon nanoparticles obtained by combustion method on primary human gingival fibroblasts (HGFs) and keratinocytes (PGKs)—relevant cell lines buccal oral mucosa. In this regard, objectives were as follows: (i) development via characterization nanosized magnetite particles with carbon their surface, (ii) biocompatibility assessment magnetic HGF PGK (iii) evaluation possible irritative reaction highly vascularized chorioallantoic membrane a...
Ultraviolet radiation (UVR) is generally considered a primary tumorigenic agent. While UVR exposure has been studied, especially at the skin level, impact of UV on internal tissues and its effect appearance development tumors not yet fully examined. Although there are maximum limits for external tissues, other such as oral tissue, can be exposed to well. Over course diagnosis treatment, cells may ultraviolet radiation; however, an established limit exposure. Therefore, aim current study was...
Cancer is a significant health problem worldwide; consequently, new therapeutic alternatives are being investigated, including those found in the vegetable kingdom. Eugenol (Eug) has attracted attention for its properties, especially stomatology. The purpose of this study was to investigate cytotoxicity Eug, vitro, on osteosarcoma (SAOS-2) and oropharyngeal squamous cancer (Detroit-562) cells, as well potential irritant effect ovo at level chorioallantoic membrane (CAM). data obtained...
Colorectal carcinoma (CRC) is one of the most frequently diagnosed cancer types with current deficient and aggressive treatment options, but various studied alternative therapies are able to efficiently contribute its management. Essential oils (EOs) contain valuable compounds, antibacterial, anti-inflammatory, anticancer properties, which might serve as effective solutions in CRC prophylaxis or treatment. The aim present work was evaluate phytochemical composition vitro biological activity...
The design and development of ceramic structures based on 3D scaffolding as dental bone substitutes has become a topic great interest in the regenerative dentistry research area. In this regard, present study focuses two scaffold-type obtained from different commercial ceramics by employing foam replication method. At same time, underlines physicochemical features biological profiles newly developed scaffolds, compared to traditional Cerabone® materials used for augmentation, both vitro...
Melissa officinalis is a medicinal herb with an extensive pharmacological profile that has been proven to have beneficial effects in oral and gastrointestinal disorders. However, the of this plant oral, pharyngeal, colorectal malignancies, types cancer increased incidence recent years, are less investigated. The present study aims evaluate total extract for potential benefits pharynx carcinoma. LC-MS MO (MOte) indicated rich content polyphenols, data support potent antioxidant capacity...
In the field of oncology, plant kingdom has an inexhaustible supply bioactive compounds. Phytochemical compounds isolated from Helleborus species have been found to be useful in various chronic diseases. This brought attention medical researchers. H. purpurascens is a characteristic Carpathian area, known since ancient times for its beneficial effects. The aim study was evaluate flavonoids composition hydroalcoholic extract purpurascens, as well assess antioxidant activity and antitumor...
Ozone is an allotropic form of oxygen, so in the medical field ozone therapy has special effects. Starting from premise that bio-oxidative reduces number bacteria, present study two approaches were proposed: to evaluate biological effects gas on tooth enamel remineralization process and demonstrate its impact morphology confluence human primary gingival cells, namely keratinocytes (PGK) fibroblasts (HGF). The produced by HealOzone was applied vivo 68 M1s (first permanent molars), both...
Space maintainers have presented an increased interest due to their chemical composition which influences the electrochemical and electrolytic processes of oral cavity, leading important biological activity. The present study was purported evaluate in vitro activity three types space (S1, S2, S3, differing from each other terms metal composition) used pediatric dentistry, antimicrobial effect biosecurity profile using two keratinocytes (PGK: primary gingival keratinocytes, HaCaT: human...