A5013072820- Natural product bioactivities and synthesis
- Essential Oils and Antimicrobial Activity
- Plant biochemistry and biosynthesis
- Phytochemicals and Antioxidant Activities
- Flavonoids in Medical Research
- Tannin, Tannase and Anticancer Activities
- Nanoparticles: synthesis and applications
- Toxin Mechanisms and Immunotoxins
- Phytochemistry and Biological Activities
- Oral microbiology and periodontitis research
- Heavy Metals in Plants
- Medicinal plant effects and applications
- Hedgehog Signaling Pathway Studies
- Orthopedic Infections and Treatments
- Sexual Differentiation and Disorders
- Ethnobotanical and Medicinal Plants Studies
- Silk-based biomaterials and applications
- Pomegranate: compositions and health benefits
- Cancer Risks and Factors
- Gastrointestinal Tumor Research and Treatment
- Biological Activity of Diterpenoids and Biflavonoids
- COVID-19 Clinical Research Studies
- Tea Polyphenols and Effects
- Multiple and Secondary Primary Cancers
- Dental Erosion and Treatment
Victor Babeș University of Medicine and Pharmacy Timișoara
2020-2025
Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș
2023-2024
Chlorhexidine (CHX) represents one of the most commonly used antiseptics in dentistry and other medical–pharmaceutical fields due to its broad-spectrum antimicrobial activity. However, potential toxic events arising from common use practice has become a subject increasing concern. Thus, present study was designed investigate toxicity CHX digluconate at concentrations covering antibacterial properties (0.0002–0.2%) HGF primary gingival fibroblasts, HaCaT immortalized human keratinocytes, JB6...
Background and Objectives: Sodium butyrate (NaB) is a potent modulator of cancer-related gene networks. However, its precise mechanisms action effects at elevated doses remain insufficiently explored. This study investigated the impact NaB physiologically relevant on key cellular metrics (viability, confluence, cell number, morphology, nuclear integrity) comprehensive set apoptosis proliferation regulators (including underexplored genes) in colorectal cancer (CRC) cells. Materials Methods:...
Cardiovascular diseases are the first cause of death in world. Ischemic heart disease is main failure. New approaches continuously sought to identify better therapeutic success. Thereby, current research has been drawn identifying and completing profile natural sources. Galium species representatives exhibiting diuretic antibacterial potential living organisms can treat burns, wounds, skin diseases. Moreover, it was also observed that these plants manifest cardioprotective effects as well...
Galium species are used worldwide for their antioxidant, antibacterial, antifungal, and antiparasitic properties. Although this plant has demonstrated its antitumor properties on various types of cancer, biological activity cutaneous melanoma not been established so far. Therefore, the present study was designed to investigate phytochemical profile two extracts G. verum L. herba (ethanolic ethyl acetate) as well (antioxidant, antimicrobial, effects) human skin cancer. The showed similar...
The biological activity of Galium verum herba was exerted on various tumor cell lines with incredible results, but their potential effect malignant melanoma has not been established yet. Therefore, the current study structured in two directions: (i) investigation phytochemical profile diethyl ether (GvDEE) and butanol (GvBuOH) extracts G. L. (ii) evaluation A375 human line. GvDEE extract showed an FT-IR different from one, high antioxidant capacity (EC50 = 0.12 ± 0.03 mg/mL > EC50 GvBuOH...
Rutin (RUT) is considered one the most attractive flavonoids from a therapeutic perspective due to its multispectral pharmacological activities including antiradical, anti-inflammatory, antiproliferative, and antimetastatic among others. Still, this compound presents low bioavailability what narrows clinical applications. To overcome inconvenience, current paper was focused on synthesis, characterization, toxicological assessment of two RUT bioconjugates obtained by enzymatic esterification...
Implementing metallic nanoparticles as research instruments for the transport of therapeutically active compounds remains a fundamentally vital work direction that can still potentially generate novelties in field drug formulation development. Gold (GNP) are easily tunable carriers phytocompounds like pentacyclic triterpenes. These formulations boost bioavailability lipophilic structure and, some instances, also enhance its therapeutic efficacy. In our work, we proposed biological vitro...
Malignant melanoma is one of the most pressing problems in developing world. New therapeutic agents that might be effective treating malignancies have developed resistance to conventional medications are urgently required. Semisynthesis an essential method for improving biological activity and efficacy natural product precursors. Semisynthetic derivatives compounds valuable sources new drug candidates with a variety pharmacological actions, including anticancer ones. Two novel semisynthetic...
Magnetic iron oxide nanoparticles were obtained for the first time via green chemistry approach, starting from two aqueous extracts of wormwood (Artemisia absinthium L.), both leaf and stems. In order to obtain magnetic suitable medical purposes, more precisely with hyperthermia inducing features, a synthesis reaction was conducted, at room temperature (25 °C) 80 °C, formulations precipitation agent. Both quality stability synthesized physiochemically characterized: phase composition (X-ray...
Cancer, in all its types and manifestations, remains one of the most frequent causes death worldwide; an important number anticancer drugs have been developed from plants, fungi animals, starting with natural compounds that were later derivatized order to achieve optimized pharmacokinetic/pharmacological profile. Betulinic acid is a pentacyclic triterpenic compound was identified as agent whose main advantage consists selective activity, which ensures almost total lack cytotoxic side...
Silver nanoparticles (AgNPs) were successfully synthesized via the biological route using a 1 M silver nitrate (AgNO3) aqueous solution and an ethanolic peel extract of Punica granatum (Pg), at 60 °C. The physicochemical analysis revealed formation green Pg-AgNPs with semi-spherical shape, non-uniformly distributed, particle size distribution between 5 100 nm. As regards preliminary in vitro toxicological screening, did not significantly affect neonatal BALB/c epidermal cells’ viability (JB6...
Determining the safety of a newly developed experimental product is crucial condition for its medical use, especially clinical trials. In this regard, four hydrogel-type formulations were manufactured, all which based on carbomer (Blank-CP940) and encapsulated with caffeine (CAF-CP940), phosphorus derivatives (phenyl phosphinic (CAF-S1-CP940) 2-carboxyethyl phenyl acids (CAF-S2-CP940)). The main aim research was to provide comprehensive outline biosafety profile above-mentioned hydrogels....
pigenin (API) is a phytocompound belonging to the subclass of flavones that can be found in both functional foods as well medicinal plants. Recent studies have assigned API antioxidant, anti-inflammatory, anti-spasmodic, anti-viral, anti-thrombotic, anti-angiogenic and chemopreventive potential vitro on various cell lines and/or experimental animal models. Apigenin-7-O-glucoside (API-7) one its main glycosides commonly chamomile flowers, parsley, celery. The aim this study was evaluate...
Ozone is an allotropic form of oxygen, so in the medical field ozone therapy has special effects. Starting from premise that bio-oxidative reduces number bacteria, present study two approaches were proposed: to evaluate biological effects gas on tooth enamel remineralization process and demonstrate its impact morphology confluence human primary gingival cells, namely keratinocytes (PGK) fibroblasts (HGF). The produced by HealOzone was applied vivo 68 M1s (first permanent molars), both...
The aim of this study is to evaluate salivary remineralisation versus chemical remineralisation/infiltration enamel, using different dentistry materials. enamel changes were studied confocal laser scanning microscopy (CLSM), and the depth lesions demineralisation/remineralisation/infiltration percentage calculated. Additionally, macro elemental composition teeth was performed atomic absorption spectroscopy (AAS). Two studies performed: (i) demineralisation in 3% citric acid infiltration...
Betulinic acid, BA, is a lupane derivative that has caught the interest of researchers due to wide variety pharmacological properties it exhibits towards tumor cells. Because their prospective increased anti−proliferative efficacy and improved profile, BA derivatives continue be described in scientific literature. The current work was conducted order determine antiproliferative activity, under an vitro environment newly developed 1,2,4−triazole BA. compounds reaction intermediates were...