A5022208868- Thermal and Kinetic Analysis
- Drug Solubulity and Delivery Systems
- Crystallization and Solubility Studies
- Chemical Thermodynamics and Molecular Structure
- Analytical Chemistry and Chromatography
- Analytical Methods in Pharmaceuticals
- Computational Drug Discovery Methods
- Energetic Materials and Combustion
- Natural product bioactivities and synthesis
- Inorganic and Organometallic Chemistry
- Chemistry and Chemical Engineering
- Synthesis and biological activity
- Polymer Synthesis and Characterization
- Crystallography and molecular interactions
- Plant biochemistry and biosynthesis
- biodegradable polymer synthesis and properties
- Synthesis and Characterization of Heterocyclic Compounds
- Polymer Nanocomposites and Properties
- Cardiovascular Health and Disease Prevention
- Polymer crystallization and properties
- Click Chemistry and Applications
- Inflammatory mediators and NSAID effects
- Phenothiazines and Benzothiazines Synthesis and Activities
- Phytochemistry and Biological Activities
- Pharmaceutical studies and practices
Victor Babeș University of Medicine and Pharmacy Timișoara
2016-2025
Polytechnic University of Timişoara
2020-2024
West University of Timişoara
2015-2016
Pentacyclic triterpenes, mainly betulin and betulinic acid, are valuable anticancer agents found in the bark of birch tree. This study evaluates extracts for active principles composition.New improved extraction methods were applied on Betula pendula order to reach maximum content principles. Extracts analyzed by HPLC-MS, Raman, SERS 13C NMR spectroscopy which revealed a very high yield (over 90%). Growth inhibiting effects measured vitro four malignant human cell lines: A431 (skin...
Sulfobutyl-ether-beta-cyclodextrin sodium salt (SBECD) is a modified cyclodextrin widely used in the pharmaceutical industry to enhance solubility and stability of poorly water-soluble drugs. As derivative beta-cyclodextrin, it produced by introducing sulfobutyl ether groups into beta-cyclodextrin molecule, which significantly increases its water decreases toxicity compared unmodified cyclodextrins. This study investigates spectral PXR diffraction characterization SBECD, thermal profile,...
The compatibility study of active substances with excipients finds an important role in the domain pharmaceutical research, being known fact that final formulation is one administered to patient. In order evaluate between substance and excipients, different analytical techniques can be used, based on their accuracy, reproducibility fastness.Compatibility two well-known substances, procaine benzocaine, four commonly used was carried out employing thermal analysis (TG/DTG/HF) Fourier Transform...
The thermal decomposition of cephalexine, cefadroxil and cefoperazone under non-isothermal conditions using the TG, respectively DSC methods, was studied. In case a hyphenated technique, including EGA, used.The kinetic analysis performed TG data in air for first step cephalosporin's at four heating rates. both were processed according to an appropriate strategy following methods: Kissinger-Akahira-Sunose, Friedman, NPK, order obtain realistic parameters, even if process is complex one.The...
This paper reports on the synthesis and characterization of two Schiff bases bearing 1,2,4-triazolic moieties, namely 4H-4-(2-hydroxy-benzylidene-amino)-5-benzyl-3-mercapto-1,2,4-triazole 4H-4-(4-nitro-benzylidene-amino)-5-benzyl-3-mercapto-1,2,4-triazole using thin layer chromatography, melting interval, elemental analysis, spectroscopy thermal stability studies.
Itraconazole is an antifungal agent included in the triazole pharmacological classification that belongs to BCS class II, characterized by a low solubility aqueous medium (of 1 ng/mL, at neutral pH), which frequently translated oral bioavailability but with high permeability. In this sense, it necessary find solutions increase/improve of itraconazole environment. The main purpose study preparation and analysis five different guest–host inclusion complexes containing intraconazole. Initially,...
Abstract Mirtazapine is an atypical antidepressant used in the management of insomnia, post-traumatic stress disorder, anxiety or panic obsessive–compulsive disorder and migraines. It worldwide pharmaceutical formulations alongside various excipients its hemihydrate form. The objective study was compatibility evaluation between MRTHH ten excipients. presence incompatibilities API selected evaluated using Fourier transform infrared spectroscopy performed on all pure samples prepared mixtures...
Olmesartan medoxomil (OLM) is a selective angiotensin II receptor antagonist used in the treatment of hypertension. Its therapeutic potential limited by its poor water solubility, leading to bioavailability. Encapsulation drug substance two methylated cyclodextrins, namely randomly β-cyclodextrin (RM-β-CD) and heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin (TM-β-CD), was carried out overcome limitation related OLM which, turn, expected result an improved biopharmaceutical profile....
Abstract Gestrinone is an active pharmaceutical ingredient used in the treatment of endometriosis as capsules, with ongoing evaluation for intravaginal administration, while also having been studied its potential antitumoral effects. The purpose this study was to determine compatibility gestrinone four excipients development solid formulations (α-lactose monohydrate, magnesium stearate, starch, and talc) obtain a fully characterized thermoanalytical profile help kinetic analysis....
The influence of excipients on the stability sodium levothyroxine pentahydrate (LTSS) under ambient conditions and thermal stress was evaluated. Since LTSS is a synthetic hormone with narrow therapeutic index, interactions can lead to drastic diminution activity. Ten commonly used pharmaceutical different roles in solid formulations were chosen as components for binary mixtures containing LTSS, namely, starch, anhydrous lactose, D-mannitol, D-sorbitol, gelatin, calcium lactate pentahydrate,...