A5085185958- Heme Oxygenase-1 and Carbon Monoxide
- Meat and Animal Product Quality
- Hemoglobin structure and function
- Ruminant Nutrition and Digestive Physiology
- Cardiac Arrest and Resuscitation
- Genetic and phenotypic traits in livestock
- Animal Nutrition and Physiology
- Aquaculture disease management and microbiota
- Pharmaceutical and Antibiotic Environmental Impacts
- Eicosanoids and Hypertension Pharmacology
- Fatty Acid Research and Health
- Cardiac Ischemia and Reperfusion
- Neuroendocrine regulation and behavior
- Antibiotic Resistance in Bacteria
- Neuroscience of respiration and sleep
- Cannabis and Cannabinoid Research
- Aortic aneurysm repair treatments
- Turtle Biology and Conservation
- Alcohol Consumption and Health Effects
- Veterinary Pharmacology and Anesthesia
- Vitamin D Research Studies
- Reproductive Physiology in Livestock
- SARS-CoV-2 detection and testing
- Pharmacological Effects and Toxicity Studies
- Pasture and Agricultural Systems
James Cook University
2015-2024
Soroti University
2024
Australian Institute of Tropical Health and Medicine
2015-2022
Townsville Hospital
2017
Queen's University
2004-2010
Louisiana State University Health Sciences Center New Orleans
2009
University of Missouri
2009
The King's University
2007
Queens University
2007
Loma Linda University
2006
We reported previously that predelivery of heme oxygenase-1 (HO-1) gene to the heart by adeno-associated virus-2 (AAV-2) markedly reduces ischemia and reperfusion (I/R)-induced myocardial injury. However, effect preemptive HO-1 delivery on long-term survival prevention postinfarction failure has not been determined. assessed survival, function, left ventricular (LV) remodeling 1 yr after infarction (MI) using echocardiographic imaging, pressure-volume (PV) analysis, histomorphometric...
Several imidazole-dioxolane compounds were synthesized and evaluated as novel inhibitors of heme oxygenase (HO). These compounds, which include (2R,4R)-2-[2-(4-chlorophenyl)ethyl]-2-[(1H-imidazol-1-yl)methyl]-4-methyl-1,3-dioxolane (1) hydrochloride, are structurally distinct from metalloporphyrin HO lack the aminothiophenol moiety azalanstat. They found to be highly selective for HO-1 isozyme (stress induced) had substantially less inhibitory potency toward HO-2, constitutive isozyme. first...
Haem oxygenases (HO) are involved in the catalytic breakdown of haem to generate carbon monoxide (CO), iron and biliverdin. It is widely accepted that products catabolism biological signaling many physiological processes. Conclusions most studies this field have gained support from judicious use synthetic metalloporphyrins such as chromium mesoporphyrin (CrMP) selectively inhibit HO. However, also been found other haem-dependent enzymes, nitric oxide synthase (NOS), cytochromes P-450 (CYPs)...
The relatively non-toxic family of cucurbit[n]uril, Q[n], have shown considerable potential in vitro as drug delivery agents, with only a few examples pharmacokinetic (PK) studies for drug⊂Q[n]. Drug-free Q[n] PK are the next step determining pharmacological applicability their potential. results first and bio-distribution drug-free 14C-Q[7] described administration via intravenous (i.v.) intraperitoneal (i.p.) dosing. A study oral 14C-Q[8] has also been undertaken to determine time course...
Reactive oxygen species (ROS) activate multiple signaling pathways involved in cardiac hypertrophy. Since HO-1 exerts potent antioxidant effects, we hypothesized that this enzyme inhibits ROS-induced cardiomyocyte hypertrophy.HL-1 cardiomyocytes were transduced with an adenovirus constitutively expressing (AdHO-1) to increase basal expression and then exposed 200 microM hydrogen peroxide (H2O2). Hypertrophy was measured using 3H-leucine incorporation, planar morphometry cell-size by...
Abstract Angiogenesis and inflammation are implicated in aortic aneurysm atherosclerosis regulated by angiopoietin-2 (Angpt2). The effect of Angpt2 administration on experimental was examined. Six-month-old male apolipoprotein E deficient (ApoE −/− ) mice were infused with angiotensin II (AngII) administered subcutaneous human Fc-protein (control) or recombinant (rAngpt2) over 14 days. Administration rAngpt2 significantly inhibited AngII-induced dilatation rupture the suprarenal aorta (SRA),...
Abstract Background Endogenous nitric oxide (NO) and carbon monoxide (CO) are generated by synthase heme oxygenase, respectively. Like NO, CO has been accepted as an important cellular signaling molecule in biological systems. An up-regulation both gene protein expression of oxygenase-1 (HO-1) under oxidative/nitrosative stress well documented, the protective role HO-1 HO-2 against oxidative damage is proposed. However, data on direct effect reactive oxygen/nitrogen species (ROS/RNS) HO...
The safe clinical use of phenytoin (PHT) is compromised by a drug hypersensitivity reaction, hypothesized to be due bioactivation the protein-reactive metabolite. Previous studies have shown PHT metabolized primary phenol metabolite, HPPH, then converted catechol which autoxidizes produce reactive quinone. known HPPH cytochromes P450 (P450s) 2C9 and 2C19 P450s 2C9, 2C19, 3A4, 3A5, 3A7. However, role many poorly expressed or extrahepatic in metabolism and/or not known. aim this study was...
Ketoconazole (KTZ) and other azole antifungal agents are known to have a variety of actions beyond the inhibition sterol synthesis in fungi. These drugs share structural features with series novel heme oxygenase (HO) inhibitors designed our laboratory. Accordingly, we hypothesized that therapeutically used azole-based effective HO inhibitors. Using gas chromatography quantify carbon monoxide formation vitro vivo, shown azole-containing potent Terconazole, sulconazole, KTZ were most...
Background and Aims. The nacht domain, leucine-rich repeat, pyrin domain-containing protein 3 (NLRP3) inflammasome is upregulated in human abdominal aortic aneurysm (AAA), but its pathogenic role unclear. aims of this study were firstly to examine whether the was a mouse model AAA secondly test inhibitor colchicine limited growth. Methods. induced eight-week-old male C57BL6/J mice with topical application elastase infrarenal aorta oral 3-aminopropionitrile (E-BAPN). For aim one, activation,...