A5088039662- Cancer and biochemical research
- Lichen and fungal ecology
- Fungal Biology and Applications
- Nanoparticle-Based Drug Delivery
- Botany and Plant Ecology Studies
- RNA Interference and Gene Delivery
- Chemical Reactions and Isotopes
- Bryophyte Studies and Records
- Electromagnetic Fields and Biological Effects
- Medicinal plant effects and applications
- Chromium effects and bioremediation
- Phytochemicals and Antioxidant Activities
- Plant Genetic and Mutation Studies
- Plant tissue culture and regeneration
- Magnetic and Electromagnetic Effects
- Heavy metals in environment
- Nanoparticles: synthesis and applications
- Digestive system and related health
- Essential Oils and Antimicrobial Activity
- Phytochemistry and Biological Activities
- Microbial Metabolism and Applications
- Natural product bioactivities and synthesis
- Plant-Derived Bioactive Compounds
- Carbon and Quantum Dots Applications
- Graphene and Nanomaterials Applications
National Institute of Research and Development for Biological Sciences
2013-2025
ETH Zurich
2023
Romanian Society of Nephrology
2019
More than one out of every three new cancers is a skin cancer, and the large majority are basal cell carcinomas (BCC). Targeted therapy targets cancer's specific genes, proteins, or tissue environment that contributes to cancer growth survival blocks as well spread cells while limiting damage healthy cells. Therefore, in present study AS1411 aptamer-functionalized liposomes for treatment BCC were obtained characterized. Aptamer conjugation increased liposome size, suggesting presence an...
In recent years, phytofunctionalized AgNPs have attracted great interest due to their remarkable biological activities. the present study, were synthesized using Abies alba and Pinus sylvestris bark extracts. The chemical profile of these extracts was analyzed by LC-HRMS/MS. As a first step, synthesis parameters (pH, AgNO3 concentration, ratio extract AgNO3, temperature, reaction time) optimized. characterized ATR-FTIR spectroscopy, DLS, SEM, EDX, TEM. Their antioxidant, cytotoxic,...
Liposomes are intensively used as nanocarriers for biology, biochemistry, medicine, and in the cosmetics industry their non-toxic biocompatible nature makes these vesicles attractive systems biomedical applications. Moreover, conjugation of specific ligands to liposomes increases cellular uptake therapeutic efficiency. Considering aspects, aim present study was obtain new formulations cationic coated with dual-peptide functionalized carboxymethyl chitosan (CMCS) treatment inner ear diseases....
ABSTRACT Skin defects caused by injuries such as burns that exceed a certain diameter no longer heal spontaneously and require more complex interventions. Hydrogels have received special attention due to their unique ability block the penetration of bacteria into wounds they can absorb contaminated exudates exhibit high degree flexibility. This study is focused on preparation characterization novel antibacterial biocomposite hydrogels based two carbohydrates, alginate hyaluronic acid (HA),...
Abstract The catalytic behavior of iron phthalocyanine (FePc)-sensitized magnetic nanocatalysts was evaluated for their application in the oxidative treatment Bisphenol A (BPA) under mild environmental conditions. Two types FePc (Fe(II)Pc and Fe(III)Pc), which are highly photosensitive compounds, were immobilized on surface functionalized magnetite. nanomaterials characterized by high resolution transmission electron microscopy (HR-TEM), X-ray diffraction (XRD), Fourier transform infrared...
Lichens represent an important resource for common traditional medicines due to their numerous metabolites that can exert diverse pharmacological activities including anticancer effects. To find new compounds with fewer side effects and low tumor resistance, a bioprospective study of Usnea barbata (L.) F.H. Wigg. (U. barbata), lichen from the Călimani Mountains (Suceava county, Romania) was performed. The aim this research investigate potential, morphologic changes, wound healing property,...
Abstract Introduction Plant species of Verbascum genus have been intensively investigated in the last decades but most studies focused on evaluation their biological activities; there are only few dealing with chemical characterisation. Objective Detailed investigation qualitative and quantitative composition, antioxidant cytogenotoxic activities a previously non‐studied ( V. ovalifolium Donn ex Sims). Methods Qualitative analysis secondary metabolites was performed by...
Nowadays, numerous biomedical studies performed on natural compounds and plant extracts aim to obtain highly selective pharmacological activities without unwanted toxic effects. In the big world of medicinal plants, Usnea barbata (L) F.H. Wigg (U. barbata) usnic acid (UA) are well-known for their therapeutical properties. One most studied properties is cytotoxicity various tumor cells. This work aims evaluate cytotoxic potential normal blood Three dry U. in solvents: ethyl acetate (UBEA),...
Lichens represent a significant source of antioxidants due to numerous metabolites that can reduce free radicals.
This study aims to complete our research on Usnea barbata (L.) Weber ex F.H. Wigg (U. barbata) from the Călimani Mountains, Romania, with an elemental analysis and explore its antibacterial antifungal potential. Thus, we analyzed twenty-three metals (Ca, Fe, Mg, Mn, Zn, Al, Ag, Ba, Co, Cr, Cu, Li, Ni, Tl, V, Mo, Pd, Pt, Sb, As, Pb, Cd, Hg) in dried U. lichen (dUB) by inductively coupled plasma mass spectrometry (ICP-MS). For second study, performed extraction five different solvents (ethyl...
Abstract Thymus species are important aromatic, medicinal and culinary plants with a significant economic value. This study evaluated for the first time chemical composition in vitro bioactivities of essential oils ( EO s) from five Moldavian T. vulgaris , T . × citriodorus calcareus ) cultivars ‘Faustini’, ‘Aureus’). The main compounds s were: thymol (55.44% 55.45%, respectively), lavandulol (54.27%), geraniol ‘Aureus’ ‘Faustini’ (60.31% 31.45%, respectively). showed most potent antioxidant...
The secondary metabolites of lichens have proven to be promising sources anticancer drugs; one the most important these is usnic acid, which a phenolic compound with dibenzofuran structure that responsible for numerous biological actions genus Usnea. As result, in this study, we related metabolite. aim present study evaluation cytotoxic activity Usnea barbata (L.) F. H. Wigg dry acetone extract (UBE). In advance, acid content was determined various extracts Wigg: liquid were found water,...
Cancer remains one of the world’s most devastating diseases and is responsible for more than 20% all deaths. It defined as uncontrolled proliferation cells spreads rapidly to healthy tissue. Controlled drug delivery systems offers great opportunities development new non-invasive strategies treatment cancers. The main advantage these their capacity accumulate in tumors via enhanced permeability retention effects. In present study, an innovative hybrid system based on nanocapsules obtained...
This research is focused on cellular response to sodium metabisulphite (E223), benzoate (E211), and nitrite (E250) application two normal mammalian cells, namely MCF-12A (ATCC CRL-3598) Vero CCL-81). The monitored parameters were cell viability (MTT assay), morphology (optical microscopy) survival (clonogenic assay). treatment was applied in doses of 12.5; 25; 50 100 µg/mL. According all tests assessed, our results proved a dose-response relationship, the most sensibility presented line.
This study describes the comparison between interaction of a series peptide-functionalized chitosan-based nanocapsules and liposomes with two cell lines, i.e., mouse macrophages RAW 264.7 human endothelial cells EA.hy926. Both types nanocarriers are loaded magnetic nanoparticles designed for anti-inflammatory therapy. The choice these nanostructures is argued based on their advantages in terms size, morphology, chemical composition, multiple possibilities modifying surface. Moreover, active...
Chitosan is a natural polymer with numerous biomedical applications. The cellular activity of chitosan has been studied in various types cancer, including melanoma, and indicates that these molecules can open new perspectives on antiproliferative action anticancer therapy. This study analyzes how different conformations, such as α-chitosan (CH) or β-oligochitosan (CO), degrees deacetylation (DDA) molar mass (MM), both concentrations CH–CO mixtures, influence the processes SK-MEL-28...
The present paper examines the effects of salt stress on growth, pigments, lipid peroxidation and antioxidant ability barley (Hordeum vulgare L.) seedlings raised from proton beam irradiated caryopses. In order to assess radiation early stages plant growth analyze its possible influence alleviation salinity, 3 5 Gy doses were used dried seeds germination occurred in presence/absence NaCl (100 mM 200 mM). After treatment, photosynthetic pigments increased variant, which registered a higher...