A5028561240- Pulmonary Hypertension Research and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Issues in Pregnancy
- Cardiovascular Function and Risk Factors
- Congenital Heart Disease Studies
- Respiratory Support and Mechanisms
- Vascular Anomalies and Treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Mechanical Circulatory Support Devices
- Long-Term Effects of COVID-19
- Medical Imaging and Pathology Studies
- Sarcoidosis and Beryllium Toxicity Research
- Heart Failure Treatment and Management
- COVID-19 Clinical Research Studies
- Liver Disease and Transplantation
- Renin-Angiotensin System Studies
- Cardiac tumors and thrombi
- Cardiac Valve Diseases and Treatments
- Ultrasound in Clinical Applications
- Blood Pressure and Hypertension Studies
- IL-33, ST2, and ILC Pathways
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Hemodynamic Monitoring and Therapy
- Neonatal Respiratory Health Research
Imperial College London
2015-2025
Royal Brompton & Harefield NHS Foundation Trust
2017-2025
Royal Brompton Hospital
2015-2024
Guy's and St Thomas' NHS Foundation Trust
2021-2024
Dartmouth College
2022-2024
NHS Greater Glasgow and Clyde
2023-2024
Harefield Hospital
2021-2023
Lung Institute
2012-2023
Dartmouth Cancer Center
2023
Stryker (United States)
2023
Acute right ventricular failure in the setting of pulmonary arterial hypertension (PAH) often requires hospitalisation intensive care units (ICU) to manage subsequent low cardiac output and its consequences. There are very few data on these acute events. We recorded demographic, clinical biological therapy consecutive patients suffering from heart requiring catecholamine treatment ICU French referral centre for hypertension. These variables were analysed according survival status ICU. 46...
<b>Background:</b> Acute chronic obstructive pulmonary disease (COPD) exacerbations use many hospital bed days and have a high rate of mortality. Previous audits shown wide variability in the length stay mortality between units not explained by patient factors. This study aimed to explore associations resources organisation care outcomes. <b>Methods:</b> 234 UK acute hospitals each prospectively identified 40 consecutive COPD admissions, documenting process outcomes from retrospective case...
C-kit(+) cells, including bone marrow (BM)-derived progenitors and mast may participate in vascular remodelling. Because recent studies suggest that c-kit be a target for innovative therapies experimental pulmonary hypertension, we investigated the contribution of c-kit(+) cells human idiopathic arterial hypertension (IPAH).To investigate IPAH.Single c-kit, CXCL12/SDF-1α, CXCR4, CD34, multiple α-smooth muscle actin (α-SMA) tryptase immunostainings were performed IPAH lungs. C-kit mRNA...
Comprehensive echocardiography assessment of right ventricular (RV) impairment has not been reported in critically ill patients with COVID-19. We detail the specific phenotype and clinical associations RV COVID-19 acute respiratory distress syndrome (ARDS).Transthoracic (TTE) measures function were collected unwell for clinical, ventilatory laboratory data.Ninety (25.6% female), mean age 52.0 ± 10.8 years, veno-venous extracorporeal membrane oxygenation (VVECMO) (42.2%) studied. A...
Apolipoprotein E (apoE), a major cholesterol carrier in the brain, is associated with strong risk for Alzheimer disease. Compared to risky APOE4 gene allele, effects of protective APOE2 allele are vastly understudied, and thus need be further clarified.We reviewed National Alzheimer's Coordinating Center clinical records performed preclinical experiments using human apoE-targeted replacement (apoE-TR) mice, which do not show amyloid pathology.Clinically, was less cognitive decline during...
Introduction Sarcoidosis-associated pulmonary hypertension (SAPH) is associated with reduced survival in single-centre studies. The international Registry for SAPH (ReSAPH) long-term follow-up was established to enrich our knowledge of this complication sarcoidosis. This analysis aims elucidate factors transplant-free patients. Methods ReSAPH contains prospectively collected outcomes patients since the time registry enrolment. Information analysed includes right heart catheterisation data,...
Abstract Background Pulmonary arterial hypertension (PAH) is a lethal vasculopathy characterized by pathogenic remodeling of pulmonary arterioles leading to increased pressures, right ventricular hypertrophy, and heart failure. PAH can be associated with other diseases (APAH: connective tissue diseases, congenital disease, others) but often the etiology idiopathic (IPAH). Mutations in bone morphogenetic protein receptor 2 ( BMPR2 ) are cause most heritable cases vast majority genetically...
Pulmonary veno-occlusive disease (PVOD) carries a poor prognosis and lung transplantation is the only curative treatment. In PVOD, epoprostenol therapy controversial, as this condition may be refractory to specific with an increased risk of pulmonary oedema. We retrospectively reviewed clinical, functional haemodynamic data 12 patients PVOD (10 histological confirmation) treated continuous intravenous priority listed for after January 1, 2003. All had severe impairment at presentation....
Pulmonary arterial hypertension (PAH) is associated with dysregulated bone morphogenetic protein receptor (BMPR)-II signaling and pulmonary vascular inflammation. We evaluated the effects of dexamethasone on monocrotaline (MCT)-induced PAH in rats for potential reversal at late time-points. Saline-treated control, MCT-exposed, MCT-exposed dexamethasone-treated (5 mg·kg −1 ·day , 1.25 2.5 ·48 h ) were day 28 35 following MCT haemodynamic parameters, right ventricular hypertrophy, morphometry,...
Objectives To assess activation of the inflammatory transcription factor NF-kappa B (NF-κB) in human idiopathic pulmonary arterial hypertension (PAH). Background Idiopathic PAH is a severe progressive disease characterized by vascular remodeling and excessive proliferation cells. Increasing evidence indicates that inflammation important pathophysiology. Methods NF-κB-p65 CD68, CD20 CD45 were measured immunohistochemistry confocal microscopy on lung specimens from patients with (n = 12)...
Mutations in the KCNK3 gene, which encodes for an outward-rectifier K+ channel, have been identified patients suffering from pulmonary arterial hypertension (PAH), and constitute first described channelopathy PAH. In human PAH experimental (PH), we demonstrated that expression function are severely reduced vascular cells, promoting PH-like phenotype at morphologic haemodynamic levels. Since channel is also expressed both rodent heart, aimed to elucidate pathophysiological role of right...