A5006598002- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Knee injuries and reconstruction techniques
- Periodontal Regeneration and Treatments
- Osteoarthritis Treatment and Mechanisms
- Digital Imaging for Blood Diseases
- COVID-19 diagnosis using AI
- Tribology and Wear Analysis
- Sports injuries and prevention
- Stress Responses and Cortisol
- Adipose Tissue and Metabolism
- AI in cancer detection
- Tendon Structure and Treatment
- SARS-CoV-2 detection and testing
- Lower Extremity Biomechanics and Pathologies
- Exercise and Physiological Responses
- Apelin-related biomedical research
- Single-cell and spatial transcriptomics
- Medicinal Plants and Bioactive Compounds
- Regulation of Appetite and Obesity
- Erythropoietin and Anemia Treatment
- Hemostasis and retained surgical items
- Cardiac Arrhythmias and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
Hungarian School Sport Federation
2022-2023
Hungarian University of Sports Science
2021-2023
Universitätsklinikum Krems
2021
University of Szeged
2011-2017
(1) Dynamic knee valgus is a predisposing factor for anterior cruciate ligament rupture and osteoarthritis. The single-leg squat (SLS) test widely used movement pattern in clinical practice that helps to assess the risk of lower-limb injury. We aimed quantify SLS using marker-less optical system. (2) Kinect validity accuracy during were established by marker-based OptiTrack MVN Xsens motion capture systems. Then, 22 individuals with moderate symptoms sports activities (Tegner > 4, Lysholm...
Plasma harvested from convalescent COVID-19 patients (CCP) has been applied as first-line therapy in the early phase of SARS-CoV2 pandemic through clinical studies using various protocols.We present data a cohort 267 hospitalized severe who received CCP. No transfusion-related complications were reported, indicating overall safety CCP therapy.Patients eventually died significantly later (3.95 versus 5.22 days after hospital admission) and had higher interleukin 6 (IL-6) levels (28.9 pg/ml...
Background: Adiponectin and leptin are implicated in the initiation pathomechanism of Alzheimer's disease (AD). The serum concentrations these adipokines has been extensively studied AD, however little is known about their receptors this disease. Objective: We developed a novel approach to examine whether adiponectin (AdipoR1 -R2) and/or (LepR) can contribute AD pathomechanism. To achieve this, we investigated effect both genetic environmental factors associated with on expression receptors....
Serological testing is a tool to predict protection against later infection. This potential heavily relies on antibody levels showing acceptable agreement with gold standard virus neutralization tests. The aim of our study was investigate diagnostic value the available serological tests in terms predicting neutralizing activity serum samples drawn 5–7 weeks after onset symptoms from 101 donors history COVID-19. Immune responses Receptor Binding Domain (RBD), Spike1 and 2 proteins...
To gain insight into the different protective mechanisms of approved vaccines, this study focuses on comparison humoral and cellular immune responses five widely used vaccines including ChAdOx1 (AZD1222, AstraZeneca), BNT162b2 (Pfizer), mRNA-1273 (Moderna), BBIBP-CorV (Sinopharm), Gam-COVID-Vac (Sputnik V).Isolated plasma from 95 volunteers' blood samples was to measure anti-SARS-CoV-2 responses. Positive controls were recovered patients COVID-19 (unvaccinated). Specific quantification kits...
We present a miniaturized immunofluorescence assay (mini-IFA) for measuring antibody response in patient blood samples. The method utilizes machine learning-guided image analysis and enables simultaneous measurement of immunoglobulin M (IgM), IgA, IgG responses against different viral antigens an automated high-throughput manner. relies on expressed through transfection, enabling use at low biosafety level fast adaptation to emerging pathogens. Using severe acute respiratory syndrome...
Influenza infection may lead to serious complications in the postpartum period, therefore, oseltamivir treatment these patients and their breastfed infants is of great importance. However, pharmacokinetics lactating women with acute influenza infection, consequent infant exposure are still unknown, data would help assessing risk need for dose adjustment infants. Six influenza-like symptoms, at a standard 75 mg oral twice daily 5 days, were recruited this phase IV clinical study during...
Stress is an integral component of life that can sometimes cause a critical overload, depending on the qualitative and quantitative natures stressors. The involvement actin, predominant dendritic integrity, plausible candidate factor in stress-induced neuronal cytoskeletal changes. major aim this study was to compare effects three different stress conditions transcription translation actin-related genes rat brain. Male Wistar rats were exposed one or other frequently used models physical...
Abstract Plasma harvested from convalescent COVID-19 patients (CCP) has been applied as first-line therapy in the early phase of SARS-CoV2 pandemic through clinical studies using various protocols. We present data a cohort 267 hospitalized, severe who received CCP. No transfusion-related complications were reported, indicating overall safety CCP therapy. Patients eventually died significantly later (3.95 versus 5.22 days after hospital admission) and had higher interleukin 6 (IL-6) levels...
Professional athletes are endangered by COVID-19 and belong to the high-risk population due their lifestyle. To obtain information on behavior of in professional athletes, serological, cytokine, virus neutralization capacities were analyzed.Hungarian national teams participated international sports events during early phases epidemic 2020. Altogether, 29 volunteered donate plasma. Their serological status was evaluated IgA, IgM, IgG ELISAs highest titer an vitro live tissue assay. Plasma...
PURPOSE: Hyperacute serum is a blood-derived product obtained from the fraction of platelet rich fibrin. It has been observed that similar products, such as platelet-rich plasma (PRP) induce improvements in injured or degenerative knee joints terms pain and mobility. However, manufacturing processes for PRP are not able to produce standarized product, leading high batch variability, limitation overcome by hyperacute serum. This study first-in-man patients with early-stage osteoarthritis....
A nemzetközi szakirodalomban a térdsérülések, keresztszalag szakadások sokszor visszavezethetők az alsó végtag izomzatának nem kielégítő működésére, illetve izomgyengeségére. statikusan, dinamikusan mért megnövekedett értéket mutató Q (quadriceps) szög – eddigi vizsgálatok alapján erősen korrelál térdfájdalommal, térdsérülések kialakulásának kockázatával. combfeszítő izom (m.quadriceps femoris), azon belül is egyenes combizom (rectus femoris) eredési pontjától, vagyis elülső csípőtövistől...
Célkitűzés: Krónikus, hegesedő kötőhártya-gyulladás miatt gondozott betegcsoportban elvégzett immunfluoreszcens vizsgálatok eredményének felmérése. Betegek és módszerek: 23 krónikus, kötőhártya-gyulladással jelentkező beteg vizsgálatának eredménye került áttekintésre retrospektív módon. A betegeknél minden esetben direkt vizsgálat (DIF) történt kötőhártyamintából. 11 indirekt vizsgálat, egy pedig salt-split-skin is történt. Eredmények: betegen 30 alkalommal DIF-tesztből 16 volt pozitív...
Abstract Here, we describe a scalable and automated, high-content microscopy -based mini-immunofluorescence assay (mini-IFA) for serological testing i.e., detection of antibodies. Unlike conventional IFA, which often relies on the use cells infected with target pathogen, our employs transfected expressing individual viral antigens. The builds custom neural network-based image analysis pipeline automated multiplexed immunoglobulins (IgG, IgA, IgM) in patient samples. As proof-of-concept,...