A5040443913- Receptor Mechanisms and Signaling
- Blood Pressure and Hypertension Studies
- Hormonal Regulation and Hypertension
- Neuroscience and Neuropharmacology Research
- Neuropeptides and Animal Physiology
- Eicosanoids and Hypertension Pharmacology
- Pharmacology and Obesity Treatment
- Heart Rate Variability and Autonomic Control
- Neurotransmitter Receptor Influence on Behavior
- Nitric Oxide and Endothelin Effects
- Cardiovascular Health and Disease Prevention
- Pain Mechanisms and Treatments
- Vitamin K Research Studies
- Pharmaceutical Practices and Patient Outcomes
- Chemotherapy-induced organ toxicity mitigation
- Ovarian function and disorders
- Hemophilia Treatment and Research
- Hearing, Cochlea, Tinnitus, Genetics
- Plant-based Medicinal Research
- Cancer, Lipids, and Metabolism
- Opioid Use Disorder Treatment
- Adipose Tissue and Metabolism
- Muscle metabolism and nutrition
- Sodium Intake and Health
- Pharmacological Receptor Mechanisms and Effects
Budapest University of Economics and Business
2021
Semmelweis University
1985-2018
Szent Imre Egyetemi Oktatókórház
1994-1999
Szent János Kórház
1996
National Healthcare Service Center
1993
Hungarian Academy of Sciences
1986-1990
National Institute on Alcohol Abuse and Alcoholism
1990
HUN-REN Institute of Experimental Medicine
1986-1989
McGill University
1983-1984
The selectivity and specificity of CH-38083 [7,8-(methylenedioxi)-14-alpha-hydroxyalloberbane HCl], a berbane derivative for alpha adrenoceptors has been studied compared with yohimbine idazoxan in peripheral tissues the central nervous system. In isolated tissue experiments was competitive antagonist at presynaptic alpha-2 on axon terminals rat vas deferens (pA2 against xylazine = 8.17 +/- 0.06) longitudinal muscle strip guinea pig ileum 8.07 0.20). As far as its postsynaptic adrenoceptor...
The effects of clonidine, naloxone, and their combination on arterial blood pressure (BP), heart rate (HR), hemodynamic biochemical parameters were examined in 29 patients with essential hypertension. Treatment for 3 days 0.3 mg/day clonidine reduced BP HR, these quickly reversed by a single injection 0.4 mg iv naloxone 17 the (responders), but not remaining 12 (nonresponders). Responders had higher control values cardiac output, stroke index, plasma renin activity (PRA), epinephrine levels...
The effect of naloxone on the hypotensive and bradycardiac action clonidine was studied in 27 hospitalized patients with uncomplicated mild-to-moderate essential hypertension. In a double-blind, crossover study, clonidine, 0.3 mg/day orally for 3 days, significantly reduced systolic diastolic blood pressure heart rate, whereas placebo ineffective. Naloxone, 0.4 mg given intravenously third day treatment, caused rapid increase rate 14 (reacting group), but ineffective remaining 13...
Diurnal rhythm of plasma beta endorphin was established with the highest level in morning and lowest one at midnight normotensive subjects also patients essential hypertension. Clonidine (300μg daily ) significantly increased concentrations only hypertensive patients. The significant linear correlation between increase concentration decrease blood pressure (both systolic diastolic) these may point to role this endogenous opioid antihypertensive action clonidine.
In this prospective, open‐label, randomized, controlled clinical trial the effects of low‐dose carvedilol, nebivolol, and metoprolol on central arterial pressure augmentation index ( AI x) its heart rate–corrected value x@75) were assessed. The authors randomized 75 hypertensive patients (18–70 years) to carvedilol 12.5/25 mg, 50/100 or nebivolol 2.5/5 mg daily followed them up for 3 months. Central x measured with applanation tonometry at baseline end follow‐up. Analyses restricted 60...
Cisplatin neuro-, oto-, and nephrotoxicity are major problems in children with malignant tumors, including medulloblastoma, negatively impacting educational achievement, socioemotional development, overall quality of life. The blood-labyrinth barrier is somewhat permeable to cisplatin, sensory hair cells cochlear supporting highly sensitive this toxic drug. Several chemoprotective agents such as N-acetylcysteine (NAC) were utilized experimentally avoid these potentially serious life-long...
Daily doses of 0.3 mg clonidine and 3 guanfacine were equiactive in decreasing blood pressure heart rate 17 subjects with essential hypertension. Clonidine decreased cardiac output total peripheral resistance, while had no effect on stroke volume but increased it. Both plasma renin activity. Naloxone, 0.4 iv, reversed the antihypertensive was ineffective even at higher (1.6 iv) when treated placebo or guanfacine. It is suggested that hemodynamic differences between two centrally acting alpha...
Background The addition of direct-acting antivirals to pegylated interferon-α plus ribavirin for the treatment chronic HCV infection can result in an increased sustained viral response rate and may permit reduction duration. IDX320 is a potent non-covalent macrocyclic inhibitor NS3/4A protease. Methods This was randomized double-blind placebo-controlled single- multiple-dose study assess safety, tolerability, antiviral activity pharmacokinetics healthy volunteers (HV) patients with genotype...
48 patients with normal-renin essential hypertension were treated prazosin alone or in combination oxprenolol. 1 h after a single dose of 2 mg tachycardia and decrease blood pressure developed. Renin activity the peripheral plasma (PRA) increased from 1.04 ± 0.15 to 2.64 0.20 ng AgT/ml/h. A 3-day treatment t.i.d. 11 caused no further pressure, while PRA returned baseline level. Treatment for 3 days 40 oxprenolol 37 decreased as well PRA. The increase could be related enhanced sympathetic...
These are the preliminary data of an open multicenter trial antihypertensive treatment with isradipine as monotherapy (dose, 4.55 ± 0.56 mg twice daily; n = 11) or (7.5 0.63 daily) in combination bopindolol (1.16 0.12 once 30) administered for 3 years to patients essential hypertension (WHO classification I II). Blood pressure was significantly decreased both groups and there no indication resistance therapy. Plasma levels total cholesterol triglycerides were by end second year treatment, a...