A5058765978- melanin and skin pigmentation
- Cancer Immunotherapy and Biomarkers
- Sperm and Testicular Function
- Ferroptosis and cancer prognosis
- Immunotherapy and Immune Responses
- Animal Nutrition and Physiology
- Acute Lymphoblastic Leukemia research
- Mast cells and histamine
- CAR-T cell therapy research
- Reproductive biology and impacts on aquatic species
- CRISPR and Genetic Engineering
- Skin Protection and Aging
- interferon and immune responses
- Effects and risks of endocrine disrupting chemicals
- Gut microbiota and health
- Reproductive Biology and Fertility
- TGF-β signaling in diseases
- Growth Hormone and Insulin-like Growth Factors
- Chronic Myeloid Leukemia Treatments
- Melanoma and MAPK Pathways
- Hypothalamic control of reproductive hormones
- Peptidase Inhibition and Analysis
- Genomic variations and chromosomal abnormalities
- Ubiquitin and proteasome pathways
- Viral gastroenteritis research and epidemiology
Semmelweis University
2023-2025
Montavid Thermodynamic Research Group
2024
National Institute of Animal Nutrition and Physiology
2020
Newcastle University
2019
The University of Texas Medical Branch at Galveston
1991-1995
The utilization of PD1 and CTLA4 inhibitors has revolutionized the treatment malignant melanoma (MM). However, resistance to targeted immune-checkpoint-based therapies still poses a significant problem.
The histological development of the quail oviduct and changes in concentrations progesterone receptor, ovalbumin, conalbumin, ovomucoid ovoglycocomponents are analyzed during period spanning 7-35 days age. initiation luminal epithelial cell proliferation is first event magnum growth. cells begin to evaginate into subepithelial stroma form tubular glands. Meanwhile, epithelium starts cellular pleomorphism through ciliogenesis. No egg white proteins detectable developing glands; at same time,...
The macromolecular content (DNA, soluble proteins and ovalbumin) of the magnum plasma concentrations oestradiol progesterone were studied during sexual development Japanese quail. Rapid growth differentiation began between 21 28 days age rapidly reached laying stage in about 20 days. This rapid change size occurred a stepwise manner: cellular proliferation was observed first, followed by synthesis accumulation specific proteins. Just before growth, different patterns: initiation epithelial...
Introduction While Immune checkpoint inhibition (ICI) therapy shows significant efficacy in metastatic melanoma, only about 50% respond, lacking reliable predictive methods. We introduce a panel of six proteins aimed at predicting response to ICI therapy. Methods Evaluating previously reported two untreated melanoma cohorts, we used published model (EaSIeR score) identify potential distinguishing responders and non-responders. Results Six initially identified the cohort correlated with...
α-inhibin was immunocytochemically localized in granulosa cells of different stages developing follicles, freshly formed corpora lutea, and scattered interstitial (pigmented or ceroid cells) ovaries 6-, 14-, 23–25-mo-old C57BL/6NNia mice. Developing follicles exhibited the greatest amount staining. Quantitation stain using an image analysis system indicated staining intensity within ovarian 14-mo-old mice greater than that The levels plasma estradiol (E2) decreased with age. number present...
Microphthalmia-associated transcription factor (MITF) plays pivotal roles in melanocyte development, function, and melanoma pathogenesis. MITF amplification occurs has been associated with resistance to targeted therapies. Here, we show that regulates a global antioxidant program increases survival of cell lines by protecting the cells from reactive oxygen species (ROS)-induced damage. In addition, this redox is correlated expression human patient-derived samples. Using zebrafish model,...
Abstract The utilization of PD1 and CTLA4 inhibitors has revolutionized the treatment malignant melanoma (MM). However, resistance to targeted immune-checkpoint-based therapies still poses a significant problem. Here we mine large scale MM proteogenomic data integrating it with cell line dependency screen, drug sensitivity identify druggable targets forecast efficacy resistance. Leveraging protein profiles from established subtypes molecular structures 82 cancer drugs, identified nine...
Abstract While Immune checkpoint inhibition (ICI) therapy shows significant efficacy in metastatic melanoma, only about 50% respond, lacking reliable predictive methods. We introduce a panel of six proteins aimed at predicting response to ICI therapy. Evaluating previously reported two untreated melanoma cohorts, we used published model (EaSIeR score) identify potential distinguishing responders and non-responders. Six initially identified the cohort correlated with predicted cohort....
Journal Article GnRH Receptor Sites Increase on the Surface of Cultured Gonadotropes Senescent C57BL/6NNia Mice Get access Terry A. Parkening, Parkening Department Anatomy and Neurosciences, University Texas Medical BranchGalveston Search for other works by this author on: Oxford Academic PubMed Google Scholar Dhananjay Pal The Journals Gerontology: Series A, Volume 50A, Issue 6, November 1995, Pages B342–B350, https://doi.org/10.1093/gerona/50A.6.B342 Published: 01 1995 history Received: 02...
Metagenomics offers exciting opportunity for diagnosis of infectious diseases.Although, it has a long way to go find its place in diagnostic laboratories, several researchers have already proved usefulness difficult culture pathogens.Simultaneous and unbiased detection the microbiological agents is unique hallmark these methods.The sequence data generated from samples can be used identification different classes microbes, antibiotic resistance genes, mutations even reconstructing genomes...
High-hyperdiploid (HHD) B-cell precursor (BCP) acute lymphoblastic leukaemia (ALL) (HHD-BCP-ALL) is defined by the presence of 51 to 67 chromosomes in leukemic cells. Despite being a major BCP-ALL subgroup childhood, molecular mechanisms leading HHD remains unknown.
Background: Childhood acute lymphoblastic leukaemia (ALL) responds well to conventional treatment, however there is a need find more targeted therapies without the associated toxicities. There great inconsistency of drug responses in cell lines, and often these do not represent outcomes observed clinic. Patient‐derived xenografts (PDXs) have been shown closely patient cancers, increasingly better demonstrate response clinically observed. However, vivo assessment multiple combinations costly...