A5075020599- melanin and skin pigmentation
- Ferroptosis and cancer prognosis
- Melanoma and MAPK Pathways
- Cancer Immunotherapy and Biomarkers
- Peptidase Inhibition and Analysis
- Biochemical Analysis and Sensing Techniques
- CRISPR and Genetic Engineering
- Lymphoma Diagnosis and Treatment
- Vitamin D Research Studies
- Rheumatoid Arthritis Research and Therapies
- Autoimmune and Inflammatory Disorders Research
- interferon and immune responses
- Mast cells and histamine
- Ubiquitin and proteasome pathways
- vaccines and immunoinformatics approaches
- Skin Protection and Aging
Semmelweis University
2022-2024
University College London
2024
The utilization of PD1 and CTLA4 inhibitors has revolutionized the treatment malignant melanoma (MM). However, resistance to targeted immune-checkpoint-based therapies still poses a significant problem.
Abstract The utilization of PD1 and CTLA4 inhibitors has revolutionized the treatment malignant melanoma (MM). However, resistance to targeted immune-checkpoint-based therapies still poses a significant problem. Here we mine large scale MM proteogenomic data integrating it with cell line dependency screen, drug sensitivity identify druggable targets forecast efficacy resistance. Leveraging protein profiles from established subtypes molecular structures 82 cancer drugs, identified nine...
In the following paper, Authors aim to describe complex relationship between pigmentation, UV addiction and vitamin D their evolutionary connections based on recent advances in research. It has been long suggested that prolonged exposure can induce a dependence-like state some individuals, with β-endorphin released from keratinocytes response UV. An benefit of may be promotion synthesis chronic exposure. Vitamin was also an driver lighter skin Northern Hemisphere, so presumably UV-induced...
Microphthalmia-associated transcription factor (MITF) plays pivotal roles in melanocyte development, function, and melanoma pathogenesis. MITF amplification occurs has been associated with resistance to targeted therapies. Here, we show that regulates a global antioxidant program increases survival of cell lines by protecting the cells from reactive oxygen species (ROS)-induced damage. In addition, this redox is correlated expression human patient-derived samples. Using zebrafish model,...