A5068794329- Acute Myeloid Leukemia Research
- Mesenchymal stem cell research
- Ultrasound and Hyperthermia Applications
- Organ Transplantation Techniques and Outcomes
- Hematopoietic Stem Cell Transplantation
- Hemoglobinopathies and Related Disorders
- Cancer, Hypoxia, and Metabolism
- Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Hepatocellular Carcinoma Treatment and Prognosis
- Acute Lymphoblastic Leukemia research
- CAR-T cell therapy research
- Intracerebral and Subarachnoid Hemorrhage Research
- Liver Disease and Transplantation
- Autophagy in Disease and Therapy
- Renal cell carcinoma treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Psoriasis: Treatment and Pathogenesis
- IL-33, ST2, and ILC Pathways
- Pediatric Urology and Nephrology Studies
- MRI in cancer diagnosis
- Biochemical and Molecular Research
- Adipose Tissue and Metabolism
- Blood groups and transfusion
- Extracellular vesicles in disease
Technical University of Munich
2017-2024
University Hospital of Zurich
2020-2021
University of Zurich
2021
Klinikum rechts der Isar
2017-2020
Ludwig-Maximilians-Universität München
2016-2017
University Medical Center of the Johannes Gutenberg University Mainz
2015
Johannes Gutenberg University Mainz
2015
Abstract The PDCD1 -encoded immune checkpoint receptor PD-1 is a key tumor suppressor in T cells that recurrently inactivated cell non-Hodgkin lymphomas (T-NHLs). highest frequencies of deletions are detected advanced disease, predicting inferior prognosis. However, the tumor-suppressive mechanisms signaling remain unknown. Here, using tractable mouse models for T-NHL and primary patient samples, we demonstrate suppresses malignancy by restricting glycolytic energy acetyl coenzyme A (CoA)...
To compare the sensitivity and specificity of contrast-enhanced ultrasound (CEUS) magnetic resonance imaging (MRI) in evaluation unclear renal lesions to histopathological outcome.A total 36 patients with a single solid lesion initial studies between 2005 2015 were included. CEUS MRI used for determining malignancy or benignancy findings correlated outcome. Out masses 28 malignant (77.8%) 8 found be benign (22.2%). Diagnostic accuracy was testes by using diagnosis as gold standard.CEUS...
Supplemental Digital Content is available in the text Clonal hematopoiesis (CH) results from acquisition of somatic mutations oncogenic driver genes hematopoietic stem and progenitor cells (HSPCs) leading to expansion blood cell clones otherwise healthy individuals.1-3 CH rarely found younger individuals but its prevalence greatly continuously increases beyond 60 years age when it can be detected at frequencies 10% 20%.4, 5 Besides being a pre-malignant condition for myeloid neoplasms...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive paralysis due to the loss of primary and secondary motor neurons. Mutations in Cu/Zn-superoxide dismutase (SOD1) gene are associated with familial ALS date numerous hypotheses for pathology exist including impairment blood-spinal cord barrier. In transgenic mice carrying mutated SOD1 genes, disrupted barrier as well decreased levels tight junction (TJ) proteins ZO-1, occludin, claudin-5...
The cellular mechanisms required to ensure homeostasis of the hematopoietic niche and ability this support hematopoiesis upon stress remain elusive. We here identify Wnt5a in Osterix+ mesenchymal progenitor stem cells (MSPCs) as a critical factor for niche-dependent hematopoiesis. Mice lacking MSPCs suffer from stress-related bone marrow (BM) failure increased mortality. Niche devoid show defective actin fiber orientation due an elevated activity small GTPase CDC42. This results incorrect...
To analyse the diagnostic performance of contrast-enhanced ultrasound (CEUS) in patients with vascular complications and transplant rejection compared to histopathological results.Our study consisted 45 retrospectively analysed that underwent liver transplantations between January 1993 December 2015 developed post-transplant rejection. CEUS examinations took place September 2006 2015. findings were correlated results.CEUS showed a sensitivity 61.5%, specificity 100.0%, positive predictive...
To compare the sensitivity and specificity of contrast-enhanced ultrasound (CEUS) computed tomography (CT) in diagnosis vascular complications after liver transplantation postoperative phase.A total 60 patients with elevated function tests initial imaging studies between July 2005 November 2015 were retrospectively analysed. CEUS CT compared their was considered as gold standard. Out 28 showed CT, which could also be detected 25 out cases using CEUS. Diagnostic accuracy tested by...
To evaluate the sensitivity and specificity of contrast-enhanced ultrasound (CEUS) computed tomography (CT) in diagnosis malignancies after liver transplantation.A total 23 patients with suspicious masses transplantation initial imaging series between September 2006 2015 were statistically analysed. CEUS CT compared their malignancy being gold standard. Out 9 showed malignant CT, which could also be detected 7 out cases using CEUS.CEUS a 77.8%, 100.0%, positive predictive value (PPV) 100.0%...
Cancer cells are in most instances characterized by rapid proliferation and uncontrolled cell division. Hence, they must adapt to proliferation-induced metabolic stress through intrinsic or acquired antimetabolic responses maintain homeostasis survival. One mechanism achieve this is reprogramming gene expression a metabolism-dependent manner. MondoA (also known as Myc-associated factor X-like protein X-interacting [MLXIP]), member of the MYC interactome, has been described an example such...
BCL10/MALT1 signaling in keratinocytes is altered human sporadic psoriasis and a critical initiator amplifier of skin inflammation mouse models.
To investigate the value of contrast-enhanced ultrasound (CEUS) in histologic prediction focal liver lesions after transplantation.10 10 patients transplantation were scanned using CEUS and results compared with histopathological results.Among lesions, 7 proofed to be benign 3 malignant. All (100%) correctly report as or malignant examination.CEUS can helpful differentiation used clinical management lesions.
Osteopenia and osteoporosis are common long-term complications of the cytotoxic conditioning regimen for hematopoietic stem cell transplantation (HSCT). We examined mesenchymal progenitor cells (MSPCs), which include skeletal progenitors, from mice undergoing HSCT. Such MSPCs showed reduced fibroblastic colony-forming units frequency, increased DNA damage, enhanced occurrence cellular senescence, whereas there was a bone volume in animals that underwent This MSPC function correlated with...
Postoperative hemorrhage after adult cranial neurosurgery is a serious complication with substantial morbidity and mortality.We investigated if an extended preoperative screening early treatment of previously undetected coagulopathies may decrease the risk postoperative hemorrhage.A prospective study cohort patients undergoing elective surgery receiving coagulatory work-up were compared to propensity matched historical control cohort. The included standardized questionnaire on patient's...
Abstract Cancer cells are in most instances characterized by rapid proliferation and uncontrolled cell division. Hence, they must adapt to proliferation-induced metabolic stress through intrinsic or acquired anti-metabolic responses maintain homeostasis survival. One mechanism achieve this is reprogram gene expression a metabolism-dependent manner. MondoA (also known as MLXIP), member of the MYC interactome, has been described an example such sensor. However, role malignancy not fully...
Abstract Allogeneic hematopoietic stem cell transplantations (HSCTs) represent a curative strategy for treating hematologic malignancies yet bear dangerous and frequently life‐threatening complications including the development of graft‐versus‐host disease. Here, we present case patient that suffered from relapsed/refractory multiple myeloma, neoplasm characterized by clonal proliferation malignant plasma cells in bone marrow. During course his disease, underwent consecutive allogeneic...
Abstract MondoA (also known as MLXIP, MAX-like protein X interacting protein) is a metabolic stress sensor and proglycolytic transcription factor potentially involved in addiction features of leukemia the Warburg effect. dimerizes with MLX within MYC interactome promotes longevity C. elegans (Johnson et al., 2014). The comprises MYC/MAX/MNT/MLX/MLXIP network: Its key players MYC, MNT MLXIP differentially mediate proliferation, differentiation, or metabolism by heterodimerization MAX MLX. We...