A5011403897- Cancer-related molecular mechanisms research
- Glioma Diagnosis and Treatment
- Cervical Cancer and HPV Research
- Digital Communication and Language
- Myasthenia Gravis and Thymoma
- Cancer-related gene regulation
- Reproductive tract infections research
- MicroRNA in disease regulation
- Linguistics, Language Diversity, and Identity
- Poxvirus research and outbreaks
- Interactive and Immersive Displays
- Tryptophan and brain disorders
- Gut microbiota and health
- Circular RNAs in diseases
- Lexicography and Language Studies
- Tactile and Sensory Interactions
- RNA modifications and cancer
- Meningioma and schwannoma management
- Cell Adhesion Molecules Research
- RNA regulation and disease
- Nail Diseases and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Syphilis Diagnosis and Treatment
- Advanced Drug Delivery Systems
- Cancer Treatment and Pharmacology
Second Affiliated Hospital of Zhejiang University
2022-2025
Nanjing University of Chinese Medicine
2022-2025
Renji Hospital
2021-2022
Ruijin Hospital
2021-2022
Shanghai Jiao Tong University
2017-2021
Johns Hopkins University
2018
The crosstalk between gut microbiota and immune state of the host is an essential focus in academia clinics. To explore dynamic role response to deficiency, we comprehensively assessed microbiome 90 mouse fecal samples, across 3 time points including two immunodeficiency models, namely severe combined immunodeficient (SCID) mice non-obese diabetic SCID (NOD/SCID) mice, with BALB/c as a control strain. Metagenome analysis revealed decrease alpha diversity clear structural separation exist...
Purpose: Metastatic non-small cell lung cancer (NSCLC) remains a global health threat, with patients facing inevitable disease progression despite standard-of-care therapy. Prior studies showed Platycodin D (PD)-induced cycle arrest and apoptosis in NSCLC via RNA regulatory network, yet elucidating PD's mechanisms is challenging the real world. Methods: Biological effects of PD on lines A549 PC-9 were assessed through vitro assays, encompassing apoptosis, proliferation, colony formation,...
Abstract In order to overcome the formidable challenges posed by intricate physiological barriers of brain, employment intranasal administration (INA) has emerged as an unconventional method for drug delivery, offering distinct advantages such non‐invasiveness and enhanced pharmacokinetic characteristics within brain. Primarily exploiting conduit offered olfactory and/or trigeminal nerve systems, INA route effectively delivers therapeutic agents. With introducing appropriate improvements...
Multidrug-resistant gonorrhea has become an urgent issue for global public health. As the causative agent of gonorrhea, Neisseria gonorrhoeae, been progressively developing resistance to nearly all prescribed antimicrobial drugs, monitoring its on a broader scale crucial agenda effective antibiotic stewardship. Unfortunately, gold standard susceptibility testing (AST) relies time and labor-intensive phenotypic assays, which lag behind current diagnostic workflow N. gonorrhoeae identification...
Non-small-cell lung cancer (NSCLC) is one of the most fatal malignant tumors harmful to human health. Previous studies report that Platycodin D (PD) exhibits anti-tumor effects in multiple cancers, including NSCLC, but underlying mechanisms are largely unknown. Accumulating evidence indicates non-coding RNAs (ncRNAs) participate NSCLC disease progression, link between PD and ncRNAs poorly elucidated. Here, we used whole transcriptome sequencing systematically investigate RNAs-associated...
An optical touch panel integrated with fingerprint recognition function has been proposed and confirmed. Through tactical design slanted grating appropriate pitch, efficient coupling of waveguide mode for sensing sufficient non‐overlapping area detecting were obtained simultaneously, meaning great potential intelligent devices.
Glial fibrillary acidic protein astrocytopathy (GFAP-A) is a rare autoimmune disease of the central nervous system that was newly reported in 2016. Previous studies have speculated pathological mechanism and clinical outcome GFAP-A lie demyelination system, but due to limitations MR, this conclusion has not been further confirmed from perspective neuroimaging. A non-invasive, quantitative measurement would be clinically valuable, given its critical role mediating GFAP-A. Here, we report case...
Objective The aim of this study was to establish a nomogram model for predicting the risk short-term recurrence in glioma patients. Methods clinical data recurrent patients were summarized and analyzed study. Univariate multivariate logistic regression analyses performed analyze correlation between after operation. A established based on results. Results total 175 with enrolled, 53 (STR) group (recurrent time ≤6 months) 122 long-term (LTR) ≥36 months). analysis revealed that age at...
Introduction: The changes in the number and function of regulatory T cells (Tregs) are thought to play important roles pathogenesis generalized myasthenia gravis (gMG). Previous studies have suggested decrease FoxP3 + Treg MG development. However, there is no study on pathophysiological mechanism − Treg, especially Tr1 cells, gMG patients. Therefore, this was conducted reveal effect pathophysiology gMG. Methods: Thirteen patients with twelve healthy volunteers were enrolled study. titer...
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