A5101916017- Pain Management and Opioid Use
- Microbial Natural Products and Biosynthesis
- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Histone Deacetylase Inhibitors Research
- Pediatric Pain Management Techniques
- Plant-Microbe Interactions and Immunity
- Plant Disease Resistance and Genetics
- Genetics and Neurodevelopmental Disorders
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Cancer survivorship and care
- Enzyme Catalysis and Immobilization
- Catalysis for Biomass Conversion
- Pain Mechanisms and Treatments
- Circular RNAs in diseases
- Adenosine and Purinergic Signaling
- Management of metastatic bone disease
- Plant biochemistry and biosynthesis
- Opioid Use Disorder Treatment
- Pharmacogenetics and Drug Metabolism
- Bone and Dental Protein Studies
- Sirtuins and Resveratrol in Medicine
- Lymphoma Diagnosis and Treatment
- Cancer Mechanisms and Therapy
Peking University
2024
Shanghai International Medical Center
2021-2022
China Jiliang University
2020-2022
Shanghai Jiao Tong University
2012-2019
XinHua Hospital
2013-2019
Xinhua Translational Institute for Cancer Pain
2017
The University of Texas MD Anderson Cancer Center
2006
Hepatocellular carcinoma (HCC) is the most common type of liver cancer. HDAC6 a transcriptional regulator histone deacetylase family, subfamily 2. Previous studies have shown that plays critical roles in transcription regulation, cell cycle progression and developmental events. However, its biological development HCC remain largely unexplored. In present study, we found mRNA protein levels were up‐regulated tissues lines. The proinflammatory cytokines, which human microenvironment, increased...
// Hong-Wei Hua 1, * , Feng Jiang 2, Qian Huang 2 Zhijun Liao Gang Ding 1 Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 200092, China Department Oncology, Chongming Branch, 202150, These authors have contributed equally this work Correspondence to: Ding, e-mail: dinggangcm@126.com Keywords: Hepatocellular carcinoma, β-catenin, MicroRNA, MicroRNA-153, WWOX Received: September 19, 2014 Accepted: December 16, Published: February 02, 2015 ABSTRACT Persistent...
Cancer has become increasingly prevalent in China over the past few decades. Among factors that determine quality of life cancer patients, pain commonly been recognized as a most critical one; it could also lead to ineffective treatment cancer. Driven by need for better management our research team developed mobile-based Intelligent Pain Management System (IPMS).Our objective was design, develop, and test IPMS facilitate real-time recording timely intervention among patients with pain. The...
Secreted protein, acidic and rich in cysteine (SPARC), a calcium-binding matricellular glycoprotein, is implicated the progression of many cancers. Currently, there growing evidence for important functions SPARC variety cancers its role cancer depends on tumor types. In this study, we reported negatively regulated glucose metabolism hepatocellular carcinoma (HCC). Overexpression inhibited uptake lactate product through downregulation key enzymes metabolism. On other hand, knock down reversed...
Background: This study explored the related factors that influence recurrence time of glioblastomas (GBM).Methods: A retrospective recurrent GBM patients with surgical resection was performed. Recurrence analyzed using Kaplan–Meier survival curves. The Cox regression model used to investigate possible associated time.Results: total 176 (113 males and 63 females) were enrolled in study, a median age 57 years (range, 19–76 years). From this cohort, 18 (10.2%) had gross (GTR), 53 (30.1%)...
The nucleoside antibiotic toyocamycin (TM) is a potential fungicide that can control plant diseases, and it has become an attractive target for research. Streptomyces diastatochromogenes 1628, TM-producing strain, was isolated by our laboratory considered to be potent industrial producer of TM. Recently, the putative TM biosynthetic gene cluster (toy cluster) in S. 1628 found genome sequencing. In this study, role toy biosynthesis investigated heterologous expression, deletion,...
Objective The aim of this study was to establish a nomogram model for predicting the risk short-term recurrence in glioma patients. Methods clinical data recurrent patients were summarized and analyzed study. Univariate multivariate logistic regression analyses performed analyze correlation between after operation. A established based on results. Results total 175 with enrolled, 53 (STR) group (recurrent time ≤6 months) 122 long-term (LTR) ≥36 months). analysis revealed that age at...
Applying 10 Hz (α-rate) sensory stimulation, not 5 (θ-rate), prior to introducing novel speech-print pairs can reset the phase of θ oscillations and enhance associative learning. This rapid gain indicates coordinated mechanisms regulate attentional/cognitive resources (α oscillations) facilitate memory storage (θ early in The present findings may inform educational practices for children with reading difficulties.
4524 Background: It is unclear whether the overall survival (OS) of patients with localized esophageal adenocarcinoma (LEA) Barrett’s (Barrett’s-positive) and those LEA without (Barrett’s-negative) following preoperative chemoradiation different. Based on anticipated differences in biology, we hypothesized that two groups will have a different OS, if large cohort analyzed. Methods: In this retrospective analysis, who had surgery were selected. Apart from age, gender, baseline clinical stage,...
Objective To investigate the relationship between plasma IL-6,ACE level and DVH parameters radiation pneumonitis,and to evaluate its clinical value on prediction of pneumonitis.Methods 60 patients with locally advanced non-small cell lung cancer unresectable or unwilling surgical resection routinely received three-dimensional conformal therapy.Before radiotherapy,radiotherapy beginning 1 week,2 weeks,3 weeks,4 weeks,5 weeks,6 weeks,8 weeks 12 weeks,enzyme-linked immunosorbent assay (ELISA)...
目的 探讨心理干预辅助治疗转移性骨肿瘤相关癌痛的临床疗效。 方法 将在上海新华医院崇明分院肿瘤科进行镇痛治疗的转移性骨肿瘤患者30例采用随机数字表法分为干预组和对照组，每组15例。干预组采用世界卫生组织（WHO）推荐的三阶梯镇痛治疗加心理干预方法，对照组单纯采用WHO推荐的三阶梯镇痛治疗方法。将患者日最高疼痛强度≤3分且爆发性疼痛<3次，记为1个疼痛控制有效日，比较两组患者的癌痛控制情况。 结果 90...
Abstract Purpose IDH1-wt glioblastoma patients with TERTp-mut had the worst prognosis, and no effective management strategy was established after tumor recurrence. The median overall survival (OS) of recurrent GBM who only received supportive therapy approximately 1.0 month. We reported outcomes (rGBM) treated anlotinib combined temozolomide (ACTT), to explore rGBM. Methods clinical data 14 rGBM ACTT collected. Therapeutic efficacy adverse effects were evaluated in every 2 months treatment....