A5040399308- Cancer-related molecular mechanisms research
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Traditional Chinese Medicine Studies
- Circular RNAs in diseases
- Advanced Nanomaterials in Catalysis
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- Cancer-related gene regulation
Nanjing University of Chinese Medicine
2022-2025
Shantou University
2013-2014
First Affiliated Hospital of Shantou University Medical College
2013-2014
Purpose: Metastatic non-small cell lung cancer (NSCLC) remains a global health threat, with patients facing inevitable disease progression despite standard-of-care therapy. Prior studies showed Platycodin D (PD)-induced cycle arrest and apoptosis in NSCLC via RNA regulatory network, yet elucidating PD's mechanisms is challenging the real world. Methods: Biological effects of PD on lines A549 PC-9 were assessed through vitro assays, encompassing apoptosis, proliferation, colony formation,...
Selective activation of Pt(IV) prodrugs within tumors has emerged as a promising strategy in tumor treatment. Although progress been made with photo- and ultrasound-activated prodrugs, concerns remain over the non-specific photosensitizers (PS) potential for phototoxicity chemical toxicity. In this study, sequential dual-locked nano-prodrug that can be activated by both acidic microenvironment light was developed. The prodrug prepared conjugating PS-locked to polymeric core, which then...
Non-small-cell lung cancer (NSCLC) is one of the most fatal malignant tumors harmful to human health. Previous studies report that Platycodin D (PD) exhibits anti-tumor effects in multiple cancers, including NSCLC, but underlying mechanisms are largely unknown. Accumulating evidence indicates non-coding RNAs (ncRNAs) participate NSCLC disease progression, link between PD and ncRNAs poorly elucidated. Here, we used whole transcriptome sequencing systematically investigate RNAs-associated...
Objective To compare the levels of lipids and uric acid in diabetic healthy subjects.Methods 300 cases diabetes our hospital were selected as observation group,and subjects same period control group.Serum indexes two groups analyzed by Hitachi 7600 automatic biochemical analyzer.The serum acid,total cholesterol triglyceride compared.Results The level group was higher than that group,without statistically significant difference (P ＞ 0.05).The incidences high significantly those ＜...
Image 1.
Objective To explore the prevalence rate of fatty liver and hyperlipidemia risk factors.Methods Retrospectively analyzed clinical data 1,300 physical examinees in our hospital from June 2011 to 2013.Analyzed factors.Results There were 96 cases examinees.The was 7.38％.The men 11.38％,while that women 2.77％,with significant difference (P ＜ 0.05).The gradually increased as patients' age.Risk factors involved smoking,drinking,obesity so on.Conclusions Male patients significantly more than female...
Objective To investigate the relevance of uric acid (UA) levels elderly who took physical examination and other related clinical diseases.Methods 2428 patients examinations in our hospital from January 2012 to July 2013 were chosen.Blood pressure,blood glucose,blood lipid,coronary disease uricemia detected analyzed statistically.Results As age grown,the incidence hyperuricemia trended raise; The can supervene hypertension,hyperglycemia,hyperlipidemia,coronary heart correlative diseases,the...