A5109743617- Flood Risk Assessment and Management
- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Hydrological Forecasting Using AI
- Diagnosis and treatment of tuberculosis
- Image and Signal Denoising Methods
Chongqing University of Science and Technology
2024
Northwest University
2023-2024
Air Force Medical University
2023-2024
Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains the leading cause of mortality a single infectious agent in world. M. tuberculosis infection could also result clinical chronic infection, known as latent TB (LTBI). Compared to current limited treatment, several subunit vaccines showed immunotherapeutic effects and were included trials. In this study, vaccine Ag85B with novel mucosal adjuvant c-di-AMP (Ag85B:c-di-AMP) was delivered intranasally persistent H37Ra mouse model,...
To prepare a lipid nanoparticle (LNP)-based subunit vaccine of Mycobacterium tuberculosis (Mtb) antigen EsxV and study its immunological characteristics, the LNP containing c-di-AMP (EsxV: C: L) was prepared by thin film dispersion method, encapsulation rate, morphology, particle size, surface charge polyphase index were measured. BALB/c mice immunized with EsxV: L nasal drops. The levels serum mucosal antibodies, transcription secretion cytokines in lung spleen, proportion T cell subsets...