A5102880815- Gut microbiota and health
- Mycobacterium research and diagnosis
- Gastrointestinal disorders and treatments
- Epigenetics and DNA Methylation
- Pancreatic and Hepatic Oncology Research
- Genomics and Phylogenetic Studies
- Diet and metabolism studies
- Power Systems and Renewable Energy
- Wind Turbine Control Systems
- Microbial Community Ecology and Physiology
- Inflammatory Bowel Disease
- Ruminant Nutrition and Digestive Physiology
- Probiotics and Fermented Foods
- Plasma Diagnostics and Applications
- Electrohydrodynamics and Fluid Dynamics
- Microbial Metabolic Engineering and Bioproduction
- Terahertz technology and applications
- Liver Disease and Transplantation
- Genetic Mapping and Diversity in Plants and Animals
- Molecular Biology Techniques and Applications
- Bioinformatics and Genomic Networks
- Bacterial Identification and Susceptibility Testing
- RNA and protein synthesis mechanisms
- Liver Disease Diagnosis and Treatment
- HVDC Systems and Fault Protection
Beijing Institute of Genomics
2023
University of Chinese Academy of Sciences
2023
Huazhong University of Science and Technology
2004-2022
ITRI International
2021
Industrial Technology Research Institute
2021
Fudan University
2020
Shanghai Center for Brain Science and Brain-Inspired Technology
2020
Hubei University of Science and Technology
2013
Abstract GMrepo (data repository for Gut Microbiota) is a database of curated and consistently annotated human gut metagenomes. Its main purpose to facilitate the reusability accessibility rapidly growing metagenomic data. This achieved by annotating microbial contents collected samples using state-of-art toolsets manual curation meta-data corresponding hosts. organizes according their associated phenotypes includes all possible related such as age, sex, country, body-mass-index (BMI) recent...
GMrepo (data repository for Gut Microbiota) is a database of curated and consistently annotated human gut metagenomes. Its main purposes are to increase the reusability accessibility metagenomic data, enable cross-project phenotype comparisons. To achieve these goals, we performed manual curation on meta-data organized datasets in phenotype-centric manner. v2 contains 353 projects 71,642 runs/samples, which significantly increased from previous version. Among 45,111 26,531 were obtained by...
Abstract Buffalo is an important livestock species. Here, we present a comprehensive metagenomic survey of the microbial communities along buffalo digestive tract. We analysed 695 samples covering eight different sites in three compartments (four-chambered stomach, intestine, and rectum). mapped ~85% raw sequence reads to 4,960 strain-level metagenome-assembled genomes (MAGs) 3,255 species-level MAGs, 90% which appear correspond new In addition, annotated over 5.8 million nonredundant...
Abstract Recent high-throughput omics techniques have produced a large amount of biological data. Visualization big data is essential to answer wide range problems. As concise but comprehensive strategy, heatmap can analyze and visualize high-dimensional heterogeneous biomolecular expression in an attractive artwork. In 2014, we developed stand-alone software package, Heat map Illustrator (HemI 1.0), which implemented three clustering methods seven distance metrics for illustration. Here,...
Diagnosis of subclinical renal rejection for early treatment can be difficult due to the stable serum creatinine levels. Although regarded as gold standard, biopsy is not deemed ideal cases where continuous monitoring required its invasiveness. Here, we present a case report transplant recipient with level but elevated donor-derived cell-free DNA (5.1%) who was monitored and response treatment, guided by testing during an extended period. Antibody revealed de novo donor-specific antibodies...
In recent decades, increasing evidence has strongly suggested that gut microbiota play an important role in many intestinal diseases including inflammatory bowel disease (IBD) and colorectal cancer (CRC). The composition of is thought to be largely shaped by interspecies competition for available resources also cooperative interactions. However, what extent the changes could attributed external factors such as diet choice internal mutual relationships among microbiota, respectively, are yet...
Gut microbes have been identified as potential markers in distinguishing patients from controls colorectal cancer, ulcerative colitis, and Crohn’s disease individually, whereas there lacks a systematic analysis to investigate the exclusive microbial shifts of these enteropathies with similar clinical symptoms. Our meta-analysis cross-disease comparisons consistent alterations each enteropathy, revealed ecosystems among marker bacteria distinct states, demonstrated necessity feasibility...
Abstract Background Compromised intestinal barrier (CIB) has been associated with many enteropathies, including colorectal cancer (CRC) and inflammatory bowel disease (IBD). We hypothesized that CIB could lead to increased host-derived contents epithelial cells into the gut, change its physio-metabolic properties, globally alter microbial community metabolic capacities. Results Consistently, we found host DNA (HDCs), calculated as percentage of metagenomic sequencing reads mapped genome,...
Microbial community classification enables identification of putative type and source the microbial community, thus facilitating a better understanding how taxonomic functional structure were developed maintained. However, previous models required trade-off between speed accuracy, faced difficulties to be customized for variety contexts, especially less studied contexts. Here, we introduced EXPERT based on transfer learning that enabled model adaptable in multiple with both high efficiency...
Abstract Biomarkers play an important role in various area such as personalized medicine, drug development, clinical care, and molecule breeding. However, existing animals’ biomarker resources predominantly focus on human diseases, leaving a significant gap non-human animal disease understanding breeding research. To address this limitation, we present BioKA (Biomarker Knowledgebase for Animals, https://ngdc.cncb.ac.cn/bioka), curated integrated knowledgebase encompassing multiple species,...
Abstract Microbial source tracking quantifies the potential origin of microbial communities, facilitates better understanding how taxonomic structure and community functions were formed maintained. However, previous methods involve a tradeoff between speed accuracy, have encountered difficulty in under many context-dependent settings. Here, we present EXPERT for context-aware tracking, which adopted Transfer Learning approach to profoundly elevate expand applicability enabling biologically...
Intelligent evaluation of carbon emission reduction level in thermal
Plasma jet devices generate plasmas in an open space (surrounding air) rather than lieu of confined discharge gaps. Hence, they can be used for direct treatment and there is also no limitation on the size object. However, to best our knowledge, dimensions plasma nozzles that have been reported literature are mainly very small (sub-millimeter several millimeters) making a large area difficult, only few jets developed. One way overcome this shortcoming use arrays. since individual plumes...
ABSTRACT Common intestinal diseases such as Crohn’s disease (CD), ulcerative colitis (UC) and colorectal cancer (CRC), share clinical symptoms altered gut microbes, necessitating cross-disease comparisons the use of multi-disease models. Here, we performed meta-analyses on thirteen fecal metagenome datasets three diseases. We identified 87 species 65 pathway markers that were consistently changed in multiple same According to their overall trends, grouped disease-enriched marker into...
Abstract Background Despite recent efforts, a single factor underlying the gut microbiota dysbiosis in intestinal diseases is not identified. We hypothesized that compromised barrier (CIB) could lead to increased host-derived contents including human cells gut, change its physio-metabolic properties, and globally alter their metabolic capacities. Results Consistently, we found DNA (HDCs), calculated as percentage of metagenomic sequencing reads mapped genome, were significantly elevated...
Wind power resources are remotely distributed in China. The fixed series compensation (FSC) is one of the traditional methods to solve problem long-distance transmission doubly-fed induction generators (DFIGs) based wind farm. introduction FSC will bring potential sub-synchronous oscillation (SSO) risks system. With development flexible AC system (FACTS), thyristor-controlled (TCSC) has become an effective substitute for due its suppression effect on oscillation. This paper mainly studied...
Abstract Background: Compromised intestinal barrier (CIB) has been associated with many enteropathies, including colorectal cancer (CRC) and inflammatory bowel disease (IBD). We hypothesized that CIB could lead to increased host-derived contents epithelial cells into the gut, change its physio-metabolic properties, globally alter microbial community metabolic capacities. Results: Consistently, we found host DNA (HDCs), calculated as percentage of metagenomic sequencing reads mapped genome,...
Abstract BackgroundCompromised intestinal barrier (CIB) has been associated with many enteropathies, including colorectal cancer (CRC) and inflammatory bowel disease (IBD). We hypothesized that CIB could lead to increased host-derived contents epithelial cells into the gut, change its physio-metabolic properties, globally alter microbial community metabolic capacities. ResultsConsistently, we found host DNA (HDCs), calculated as percentage of metagenomic sequencing reads mapped genome, were...