A5101434881- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- RNA modifications and cancer
- Nutrition and Health in Aging
- Innovations in Medical Education
- MicroRNA in disease regulation
- Mechanisms of cancer metastasis
- Muscle metabolism and nutrition
- Kruppel-like factors research
- Magnesium in Health and Disease
- Clinical Nutrition and Gastroenterology
- Circular RNAs in diseases
- Mycobacterium research and diagnosis
- Parathyroid Disorders and Treatments
- Evaluation and Optimization Models
- Ginkgo biloba and Cashew Applications
- Muscle Physiology and Disorders
- Medical Education and Admissions
- Endoplasmic Reticulum Stress and Disease
- Regulation of Appetite and Obesity
- Bariatric Surgery and Outcomes
- Safety and Risk Management
- Facial Trauma and Fracture Management
- Diet and metabolism studies
- Oral and gingival health research
West China Medical Center of Sichuan University
2023-2025
Zhengzhou University
2024
Sichuan University
2006-2024
State Key Laboratory of Biotherapy
2019-2024
Second Xiangya Hospital of Central South University
2019-2021
Central South University
2019-2021
West China Hospital of Sichuan University
2015-2016
Chengdu University
2016
Cangzhou Central Hospital
2016
Metabolic dysfunction-associated fatty liver disease (MAFLD) is a major cause of liver-related morbidity and mortality, contributing to both cardiovascular non-cardiovascular deaths. The Body Roundness Index (BRI) Systemic Immune-Inflammation (SII) have emerged as predictors adverse outcomes in metabolic diseases. This study investigates the association between BRI, SII, mortality risk MAFLD patients. A nationwide retrospective cohort was conducted using data from NHANES database (January...
ABSTRACT Sarcopenia is a known risk factor for cardiovascular disease (CVD) in individuals with diabetes or prediabetes, but the impact of changes sarcopenia status on CVD remains unclear. This study aimed to examine how between baseline and second follow‐up survey, conducted 2 years later, influence developing incident CVD. Incident was identified based self‐reported physician diagnoses heart disease, such as angina, myocardial infarction, failure, stroke. Cox proportional hazard models...
The incidence of thyroid carcinoma has obviously been rising throughout the world during past ten years.
Abstract Vaccines have proven effective in protecting populations against COVID-19, including the recombinant COVID-19 vaccine (Sf9 cells), first approved protein China. In this positive-controlled trial with 85 adult participants cells group: n = 44; CoronaVac 41), we evaluated safety, immunogenicity, and protective effectiveness of a heterologous boost Sf9 adults who had been vaccinated inactivated vaccine, found post-booster adverse events rate 20.45% group 31.71% ( p 0.279), within 28...
GSK3α and GSK3β are two GSK3 isoforms with 84% overall identity 98% in their catalytic domains. plays important roles the pathogenesis of cancer, while has long been considered a functionally redundant protein GSK3β. Few studies have specifically investigated functions GSK3α. In this study, unexpectedly, we found that expression GSK3α, but not GSK3β, was significantly correlated survival colon cancer patients 4 independent cohorts. To decipher profiled phosphorylation substrates uncovered...
Objective: The manuscript investigates the relation between adiponectin gene (ADIPOQ) polymorphisms and type 2 diabetes mellitus (T2DM) in a Chinese population. Methods: We designed case-control study involving 340 normal glucose tolerant (NGT) subjects patients. Three SNPs (rs182052, rs1501299, rs7627128) were genotyped by TaqMan methods. Results: found that rs7627128, rs1501299 rs182052 significantly associated with T2DM. Haplotypes analysis indicated frequency of haplotypes A-A-T was...
Fibroblast growth factor (FGF) and tumor factor-β (TGFβ) have emerged as pivotal regulators during the progression of osteosarcoma (OS). LHX9 is one crucial transcription controlled by FGF, however, its function in OS has not been investigated yet.The expression LHX9, FRS2, BMP4, TGF-beta R1, SMAD2, beta-catenin metastasis-related proteins was measured real-time quantitative PCR (RT-qPCR) Western blot. CCK-8 assay colony formation were employed to determine proliferation cells, while scratch...
Gastrointestinal stromal tumor (GIST) is a common sarcoma of gastrointestinal tract (GIT) with high metastatic and recurrence rates, but the proteomic features are still less understood. Here we performed systematic quantitative proteome profiling GIST from 13 patients classified into very low/low, intermediate risk subgroups. An extended cohort (n = 131) was used for immunohistochemical validation proteins interest. In total, 9177 were quantified, covering 55.9% GIT transcriptome The Human...
Abstract Magnesium (Mg) deficiency is associated with increased risk and malignancy in colorectal cancer (CRC), yet the underlying mechanisms remain elusive. Here, we used genomic, proteomic, phosphoproteomic data to elucidate impact of Mg on CRC. Genomic analysis identified 160 genes higher mutation frequencies Low-Mg tumors, including key driver such as KMT2C ERBB3. Unexpectedly, initiation CRC, TP53 APC, displayed High-Mg tumors. Additionally, proteomic indicated that low content tumors...
Given the increasing complexity of transportation systems and critical need for effective safety oversight, this study aims to evaluate improve supervision (TSS) system in Henan Province, China. Based on questionnaire data from relevant units China, a three-level index effectiveness TSS consisting 4 criterion-level indicators 25 factory-level is established. By combining analytic hierarchy process (AHP) grey theory, hierarchical evaluation model constructed current situation Province. The...
Emerging studies have explored the prognostic value of MIR31HG in cancers, but its role remains elusive. Herein, we aimed to summarize potential this study.Several databases were searched for literature retrieval on Dec 5, 2019. Overall and subgroup analyses conducted measure relationship between expression clinical outcomes. Moreover, GEPIA was applied validation tumor patients TCGA dataset.Overall, seventeen with 2573 enrolled. Compared counterparts, those high tended shorter RFS. Notably,...
Long noncoding RNAs (lncRNAs) have critical regulatory functions in biological and pathological activities during osteosarcoma progression. It is important to elucidate the expression pattern reveal underlying mechanisms of newly identified lncRNAs.Herein, we screened differentially expressed lncRNAs tumors cell lines using lncRNA microarray. The candidate was further verified by qRT-PCR, association gene with clinicopathological features evaluated Kyoto Encyclopedia Genes Genomes (KEGG)...
Abstract Mental disorders are associated with dysregulated metabolism, but comprehensive investigations of their metabolic similarities and differences clinical relevance few. Here, based on the plasma metabolome lipidome subcohort1, comprising 100 healthy participants, 55 cases anxiety, 52 persons depression, 41 individuals comorbidity, which from WCHAT, a perspective cohort study community‐dwelling older adults aged over 50, multiple metabolites as potential risk factors mental were...
Homeobox B7 (HOXB7), a member of the HOX gene family, plays role in tumorigenesis. However, until now expression status and HOXB7 osteosarcoma remain unclear. Therefore, present study aimed to investigate functional mechanism osteosarcoma. Our results demonstrated that was overexpressed cell lines. Downregulation significantly inhibited proliferation vitro, as well attenuated xenograft tumor growth vivo. also migration invasion cells. Furthermore, downregulation suppressed protein levels...
Abstract Background Emerging studies have explored the prognostic value of MIR31HG in cancers, but its role remains elusive. Herein, we aimed to summarize potential this study. Methods Several databases were searched for literature retrieval on Dec 5, 2019. Overall and subgroup analyses conducted measure relationship between expression clinical outcomes. Moreover, GEPIA was applied validation tumor patients TCGA dataset. Results Overall, seventeen with 2,573 enrolled. Compared counterparts,...
Innovation is the lifeline of medical education reform in new era. Based on strategic goals Healthy China Initiative, we presented this paper practical experience Department General Practice, West Hospital, Sichuan University. We proposed construction an integrated model general practitioner (GP) core competency training program consisting 4 components, service, management, education, and academic ability. The integration "generalist-specialist" "hospital-community health service center"...
Abstract Magnesium (Mg) deficiency is associated with increased risk and malignancy of colorectal cancer (CRC), yet the underlying mechanisms remain elusive. Here we used genomic, proteomic, phosphoproteomic data to elucidate impact Mg on CRC. Genomic analysis identified 160 genes higher mutation frequencies in Low-Mg tumors, including key driver such as KMT2C ERBB3 . Unexpectedly, initiation CRC, TP53 APC , displayed High-Mg tumors. Additionally, proteomics phosphoproteomics indicated that...
Background: Previous studies have indicated a potential correlation between renal function and risk of cancer. However, establishing causal relationship is challenging. To address this, we employed Mendelian randomization (MR), novel method that utilizes genotype data to simulate randomized trial groups, investigate whether there the esophageal cancer (EC) risk. Methods: MR analysis was conducted with individual-level on EC from UK Biobank published dataset. Genetic instruments were derived...
Chronic insomnia is a common yet often overlooked issue in primary health care. This study investigated the knowledge, attitude, and practices of chronic management among general practitioners (GPs).