A5101855924- Cancer-related molecular mechanisms research
- Neurological Disease Mechanisms and Treatments
- Nanoplatforms for cancer theranostics
- RNA modifications and cancer
- Acupuncture Treatment Research Studies
- Luminescence and Fluorescent Materials
- Circular RNAs in diseases
- Cancer, Lipids, and Metabolism
- RNA Research and Splicing
- Ubiquitin and proteasome pathways
- RNA and protein synthesis mechanisms
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- Lipid metabolism and biosynthesis
- Fibroblast Growth Factor Research
- Neuroblastoma Research and Treatments
- Porphyrin and Phthalocyanine Chemistry
- Advanced Fluorescence Microscopy Techniques
- Ferroptosis and cancer prognosis
- Biomarkers in Disease Mechanisms
- Barrier Structure and Function Studies
- PI3K/AKT/mTOR signaling in cancer
- Inflammasome and immune disorders
- Kruppel-like factors research
- Hippo pathway signaling and YAP/TAZ
Gansu University of Traditional Chinese Medicine
2016-2025
Baylor Genetics
2025
Baylor College of Medicine
2014-2025
Southern University of Science and Technology
2024
Nanchang University
2024
Third Affiliated Hospital of Nanchang University
2024
Shandong University of Traditional Chinese Medicine
2023
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2023
Universiti Putra Malaysia
2023
Wenzhou Medical University
2021
Three AIE-active Ir(<sc>iii</sc>) complexes that preferentially accumulate in the mitochondria of cancer cells through endocytosis were manifested a lit up photodynamic activity with efficient lethality towards and multicellular tumor spheroids under two-photon irradiation.
Compared to 2PE (two-photon excitation) microscopy, 3PE microscopy has superior spatial resolution, deeper tissue penetration, and less defocused interference. The design of suitable agents with a large Stokes shift, good three-photon absorption (3PA), subcellular targeting, fluorescence lifetime imaging (FLIM) properties, is challenging. Now, two IrIII complexes (3PAIr1 3PAIr2) were developed as efficient phosphorescence (3PP) agents. Calculations reveal that the introduction new group...
The endoplasmic reticulum (ER) is an indispensable organelle that undertakes the synthesis and export of proteins membrane lipids. Subtle interferences ER redox signaling pathway are very likely to cause ER-stress induced apoptosis. In view this, we herein present a series ER-targeted Ir(iii) complexes (Ir1-Ir3) as photodynamic therapy (PDT) photosensitizers with gradually extended conjugation area in main ligand, study correlation between PDT performance. results showed all these can...
Abstract Osteoarthritis (OA) is a prevalent degenerative joint disease whose pathogenesis remains unclear. The research aims to investigate the roles of Circ_0136474/miR‐127‐5p/MMP‐13 axis in OA. Differentially expressed circRNAs and miRNAs OA cartilage tissue were screened out visualized by R project based on RNA‐seq data microarray respectively. qRT‐PCR was carried for detection relative expression levels Circ_0136474, miR‐127‐5p, MMP‐13 other inflammatory factors Western blot analysis...
Herein we present a series of DCA-Ir(iii) co-drug complexes that preferentially accumulate in mitochondria and selectively cause cancer cell metabolic alterations were found to act synergy by sensitizing cells for PDT achieve cancer-specific enhanced two-photon the hypoxic environment multicellular tumor spheroids.
Abstract Long-chain acyl-CoA dehydrogenase (ACADL) is a mitochondrial enzyme that catalyzes the initial step of fatty acid oxidation, but role ACADL in tumor biology remains largely unknown. Here, we found was frequently downregulated hepatocellular carcinoma (HCC), and its low expression significantly correlated with poor clinical prognosis HCC patients. Restoring cells resulted cell cycle arrest growth suppression through suppressing Hippo/YAP signaling evidenced by decreased YAP nuclear...
A series of NIR-emitting Ir(<sc>iii</sc>) complexes were developed for multimodal imaging mitochondria under two-photon excitation.
Aberrant expression of heparanase (Hpa) is associated with apoor prognosis in ovarian and cervical cancer patients. Inhibitors Hpa can prevent the growth metastasis malignant tumor cells, suramin may be such a compound that has strong anti-proliferative effects on several kinds cells. We have therefore tested whether inhibiting effect cells due to downregulation expression.Suramin at 300-600 μg/ml significantly inhibited HO-8910 PM HeLa cell 24 h, both time-dependent dose-dependent manner,...
To observe the effect of heat-reinforcing needling on expression profile long non-coding RNA (LncRNA) in synovial tissue rabbits with cold-syndrome type rheumatoid arthritis (RA), so as to explore its mechanisms underlying improvement RA. A total 18 New Zealand were randomly divided into normal, model and (acupuncture) groups, 6 each group. The RA was established by injection mixed solution (emulsifier) ovalbumin powder(80 mg) + NaCl (20 mL) +Freund's complete adjuvant mL), combined cold...
Hepatocellular carcinoma (HCC) is one of the most malignant tumor types and has a high incidence mortality. Many miRNAs play important roles in development HCC. Identification these their targets increasingly urgent for better understandingof miRNA function both physiological pathological contexts. studies have shown that expression let-7 often downregulated process tumorigenesis, suggesting may participate this as an oncogene.Immunochemistry staining was used to observe let-7b HCC tissues....
Abstract We aimed to assess the clinicopathological features and determine prognostic factors of cervical adenocarcinoma (AC). Relevant data were extracted from surveillance, epidemiology end results database 2004 2015. The log-rank test Cox proportional hazard analysis subsequently utilized identify independent factors. A total 3102 patients identified. enrolled characterized by higher proportion early FIGO stage (stage I: 65.9%; II: 14.1%), low pathological grade (grade I/II: 49.1%) tumor...
Background. Hepatocellular carcinoma (HCC) is one of the common causes cancer resulting in death China. Here, we found that spindle- and kinetochore-associated complex subunit 1 (SKA1) a critical factor plays an essential role regulation HCC cell proliferation apoptosis. Methods. Using immunohistochemistry 38 tissues, showed expression SKA1 was upregulated tissues compared with normal tissues. Then, investigated effects SKA1-targeted small interfering RNA (siRNA) on apoptosis as cells. siRNA...
Abstract Osteosarcoma (OS) is a highly malignant tumor, and its dysregulated lipid metabolism associated with tumorigenesis unfavorable prognosis. Interestingly, long noncoding RNAs (lncRNAs) have emerged as pivotal regulators of metabolism, exerting notable impacts on tumor proliferation. Nevertheless, the involvement RPARP-AS1, novel metabolism-associated lncRNA, remains unexplored in context OS. This study aims to identify functionally relevant lncRNAs impacting OS proliferation seeks...
The multifunctional RNA-binding protein, CUGBP1, regulates splicing, stability and translation of mRNAs. Previous studies have shown that CUGBP1 is expressed at high levels in the liver, although its role hepatocellular carcinoma unknown. Our aim was to determine if could regulate growth.Expression were analyzed 70 hepatic 20 normal tissue samples by immunohistochemistry (IHC). Using lentivirus-mediated short hairpin RNA (shRNA), expression human HepG2 cells knocked-down. effect on cancer...
Abstract Compared to 2PE (two‐photon excitation) microscopy, 3PE microscopy has superior spatial resolution, deeper tissue penetration, and less defocused interference. The design of suitable agents with a large Stokes shift, good three‐photon absorption (3PA), subcellular targeting, fluorescence lifetime imaging (FLIM) properties, is challenging. Now, two Ir III complexes (3PAIr1 3PAIr2) were developed as efficient phosphorescence (3PP) agents. Calculations reveal that the introduction new...
the aim of this study was to evaluate prognostic significance preoperative serum lipid in patients with gallbladder cancer (GBC).ninety-nine GBC between October 2009 and December 2013 were reviewed retrospective study. Total cholesterol (TC), total triglyceride (TG), high density lipoprotein (HDL-C), low (LDL-C), apolipoprotein A (Apo-A), B (Apo-B) free fatty acids (FFA) measured before surgery. The correlation levels clinical data, including gender, age, tumor size, lymph nodes metastasis,...