A5041802206- Analytical Methods in Pharmaceuticals
- Analytical Chemistry and Chromatography
- Antibiotics Pharmacokinetics and Efficacy
- PARP inhibition in cancer therapy
- Glioma Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Peptidase Inhibition and Analysis
- Pesticide Residue Analysis and Safety
- Phytochemistry and biological activity of medicinal plants
- Pharmacological Effects and Assays
- Analytical chemistry methods development
- Radiomics and Machine Learning in Medical Imaging
- Inflammatory mediators and NSAID effects
- Bioactive Compounds and Antitumor Agents
- Analytical Chemistry and Sensors
- Drug Transport and Resistance Mechanisms
- Essential Oils and Antimicrobial Activity
- Natural product bioactivities and synthesis
- Morinda citrifolia extract uses
- Phytochemicals and Antioxidant Activities
- Prostate Cancer Treatment and Research
- Plant chemical constituents analysis
- Immune cells in cancer
- Neuropeptides and Animal Physiology
UCLA Jonsson Comprehensive Cancer Center
2021-2025
University of California, Los Angeles
2020-2025
Molecular Theranostics (United States)
2022-2025
University of Chieti-Pescara
2013-2023
UCLA Health
2021
University of Basilicata
2021
New York University
2018-2020
Memorial Sloan Kettering Cancer Center
2015-2019
Advanced Imaging Research (United States)
2019
NYU Langone Health
2018
Abstract Tissue macrophage numbers vary during health versus disease. Abundant inflammatory macrophages destruct tissues, leading to atherosclerosis, myocardial infarction and heart failure. Emerging therapeutic options create interest in monitoring patients. Here we describe positron emission tomography (PET) imaging with 18 F-Macroflor, a modified polyglucose nanoparticle high avidity for macrophages. Due its small size, Macroflor is excreted renally, prerequisite the isotope flourine-18....
Fibroblast activation protein (FAP)–expressing cancer-associated fibroblasts confer treatment resistance and promote metastasis immunosuppression. Because FAP is overexpressed in many cancers, radiolabeled molecules targeting are studied for their use as pancancer theranostic agents. This study aimed to establish the spectrum of expression across various cancers by immunohistochemistry explore whether <sup>68</sup>Ga inhibitor (FAPi)–46 PET biodistribution faithfully reflects from resected...
The University of California Los Angeles (UCLA) and San Francisco (UCSF) codeveloped 68Ga-PSMA-11 by conducting a bicentric pivotal phase 3 clinical trial for PET imaging prostate cancer. On December 1, 2020, 2 separate new drug applications (NDAs) submitted each institution (NDA 212642 UCLA NDA 212643 UCSF) were approved the Food Drug Administration as first prostate-specific membrane antigen (PSMA)-positive lesions in men with This article briefly describes background, development,...
This study sought to develop an integrative positron emission tomography (PET) with magnetic resonance imaging (MRI) procedure for accurate atherosclerotic plaque phenotyping, facilitated by clinically approved and nanobody radiotracers. Noninvasive characterization of atherosclerosis remains a challenge in clinical practice. The limitations current diagnostic methods demonstrate that, addition morphology composition, disease activity needs be evaluated. We screened 3 radiotracers targeted...
A nanoimmunotherapy reduces inflammation in mouse, rabbit, and pig models of atherosclerosis.
The DNA repair enzyme poly(ADP-ribose) polymerase 1 (PARP-1) is overexpressed in glioblastoma, with overall low expression healthy brain tissue. Paired the availability of specific small molecule inhibitors, PARP-1 a near-ideal target to develop novel radiotherapeutics induce damage and apoptosis cancer cells, while sparing <b>Methods:</b> We synthesized an <sup>131</sup>I-labeled therapeutic investigated its pharmacology vitro vivo. A subcutaneous tumor model was used quantify retention...
Recently, various approaches have been addressed to improve chromatographic performance in terms of sensitivity or selectivity, from the development novel on-line (or off-line) enrichment methodologies, improvement stationary-phase type and multidimensional chromatography, more performing detectors such as tandem mass spectrometry (MS/MS), nuclear magnetic resonance (NMR), infrared (IR). For analysis complex matrices (e.g., biological fluids, plant extracts, food, environmental samples),...
Several studies have shown that xanthones obtained from Garcinia Mangostana (GM) remarkable biological activities. α-mangostin (α-MG) is the main constituent of fruit hull GM. findings suggested SIRT-1, a nuclear histone deacetylase, could influence cellular function by inhibition NF-kB signaling. ROS can inhibit SIRT-1 activity initiating oxidative modifications on its cysteine residues, and suppression enhances NF-κB signaling resulting in inflammatory responses. The goals present study...
Abstract Introduction: Glioblastoma (GBM) is the most common and aggressive primary brain tumor. The 5-year survival rate only 4% despite current standard treatment approaches of surgery, chemotherapy, radiation. Fibroblast Activation Protein (FAP)-targeted radioligand therapy (RLT) has emerged as a potential alternative to traditional radiation methods. FAP protein highly expressed in Cancer-Associated Fibroblasts (CAFs) on GBM cells. It can be targeted by radiolabeled molecules for...
Abstract Background Prostate cancer (PC) has a 34% 5-year survival rate after progressing to metastatic castration-resistant prostate (mCRPC), which occurs in 20–30% of cases. Treatments like chemotherapy, immunotherapy, and PSMA-targeted radioligand therapy (RLT) show promise, but challenges remain with tumor resistance, side effects, dose-limiting toxicity kidneys bone marrow. This study investigated the hematotoxicity, treatment efficacy, recovery [ 177 Lu]Lu-PSMA-617 225 Ac]Ac-PSMA-617...
Abstract Introduction – Rhamnus alpinus L. (Rhamnaceae), a traditional plants in the flora of Abruzzo region, is known to contain active anthraquinone secondary metabolites. However, content anthraquinones varies among R. samples depending on collection season and site. Thus, using simple, reliable accurate analytical methods for determination extracts allows comparative study different extraction. Objective After partial validation an HPLC method simultaneous five anthraquinones,...