A5036150768- Atherosclerosis and Cardiovascular Diseases
- Lipoproteins and Cardiovascular Health
- Nanoparticle-Based Drug Delivery
- Cell Adhesion Molecules Research
- MicroRNA in disease regulation
- Erythrocyte Function and Pathophysiology
- Blood groups and transfusion
- Extracellular vesicles in disease
- Cholesterol and Lipid Metabolism
- Phagocytosis and Immune Regulation
- Lipid Membrane Structure and Behavior
- Angiogenesis and VEGF in Cancer
- Proteoglycans and glycosaminoglycans research
- Hemoglobinopathies and Related Disorders
- Protease and Inhibitor Mechanisms
- Fatty Acid Research and Health
- RNA Interference and Gene Delivery
- Seaweed-derived Bioactive Compounds
- Protein purification and stability
- Adipokines, Inflammation, and Metabolic Diseases
- Surfactants and Colloidal Systems
- Advanced Biosensing Techniques and Applications
- Machine Learning in Materials Science
- Eicosanoids and Hypertension Pharmacology
- Cancer therapeutics and mechanisms
AbbVie (United States)
2020-2021
University of Twente
2015-2018
Icahn School of Medicine at Mount Sinai
2016-2018
Utrecht University
2013-2017
University of Oxford
2016
University Medical Center Utrecht
2013
Abstract Cells release nano-sized membrane vesicles that are involved in intercellular communication by transferring biological information between cells. It is generally accepted cells at least three types of extracellular (EVs): apoptotic bodies, microvesicles and exosomes. While a wide range putative functions have been attributed to exosomes, they assumed represent homogenous population EVs. We hypothesized the existence subpopulations exosomes with defined molecular compositions...
Hyaluronan is a biologically active polymer, which can be formulated into nanoparticles. In our study, we aimed to probe atherosclerosis-associated inflammation by using hyaluronan nanoparticles and determine whether they ameliorate atherosclerosis. (HA-NPs) were prepared reacting amine-functionalized oligomeric (HA) with cholanic ester labeled fluorescent or radioactive label. HA-NPs characterized in vitro several advanced microscopy methods. The targeting properties biodistribution of...
Immunological complexity in atherosclerosis warrants targeted treatment of specific inflammatory cells that aggravate the disease. With initiation large phase III trials investigating immunomodulatory drugs for atherosclerosis, cardiovascular disease enters a new era. We here propose radically different approach: implementing and evaluating vivo combinatorial library nanoparticles with distinct physiochemical properties differential immune cell specificities. The library's are based on...
This study sought to develop an integrative positron emission tomography (PET) with magnetic resonance imaging (MRI) procedure for accurate atherosclerotic plaque phenotyping, facilitated by clinically approved and nanobody radiotracers. Noninvasive characterization of atherosclerosis remains a challenge in clinical practice. The limitations current diagnostic methods demonstrate that, addition morphology composition, disease activity needs be evaluated. We screened 3 radiotracers targeted...
Inflammation, oxidative stress, and uncontrolled cell proliferation are common key features of chronic inflammatory diseases, such as atherosclerosis cancer. ω3 polyunsaturated fatty acids (PUFAs; also known omega3 or fish oil) have beneficial effects against inflammation upon dietary consumption. However, these cannot be fully exploited unless diets enriched with high concentrations oil supplements over long periods time. Here, a nanomedicine-based approach is presented for delivering...
Atherosclerosis is a leading cause of worldwide morbidity and mortality whose management could benefit from novel targeted therapeutics. Nanoparticles are emerging as drug delivery systems in chronic inflammatory disorders. To optimally exploit nanomedicines, understanding their biological behavior crucial for further development clinically relevant efficacious nanotherapeutics intended to reduce plaque inflammation. Here, three i.e., high-density lipoprotein ([S]-HDL), polymeric micelles...
Abstract Understanding the formation process of nanoparticles is utmost importance to improve their design and production. This especially holds true for self‐assembled whose processes have been largely overlooked. Herein, we present a new technology that integrates microfluidic‐based nanoparticle synthesis method Förster resonance energy transfer (FRET) microscopy imaging visualize self‐assembly in real time. Applied different systems, example, nanoemulsions, drug‐loaded block‐copolymer...
Active targeting of nanoparticles through surface functionalization is a common strategy to enhance tumor delivery specificity. However, active strategies tend work against long polyethylene glycol's shielding effectiveness and associated favorable pharmacokinetics. To overcome these limitations, we developed matrix metalloproteinase-2 sensitive surface-converting glycol coating. This coating prevents nanoparticle-cell interaction in the bloodstream, but, once exposed metalloproteinase-2,...
This work presents an end-to-end approach for assessing the absolute bioavailability of highly hydrophobic, poorly water-soluble compounds that exhibit high nonspecific binding using venetoclax as a model drug. The utilizes stable labeled i.v. microdose and requires fewer resources compared with traditional approaches use radioactive 14 C-labeled compounds. internal standard were synthesized, then formulation was developed. In clinical study, female subjects received single oral dose 100 mg...
The objective of our work was to investigate the effects different types nanoparticles on endothelial (HUVEC) and monocytic cell functions. We prepared tested 14 nanosystems comprising liposomes, lipid nanoparticles, polymer, iron oxide nanoparticles. Some contained targeting, therapeutic, or contrast agent(s). effect particles (0–400 µg/mL) endothelial-monocytic interactions in response TNF-α investigated using an arterial bifurcation model dynamic monocyte adhesion assay. Spontaneous HUVEC...
Abstract Understanding the formation process of nanoparticles is utmost importance to improve their design and production. This especially holds true for self‐assembled whose processes have been largely overlooked. Herein, we present a new technology that integrates microfluidic‐based nanoparticle synthesis method Förster resonance energy transfer (FRET) microscopy imaging visualize self‐assembly in real time. Applied different systems, example, nanoemulsions, drug‐loaded block‐copolymer...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)