A5101631268- Hydrogen's biological and therapeutic effects
- Aluminum Alloys Composites Properties
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- NF-κB Signaling Pathways
- Additive Manufacturing and 3D Printing Technologies
- Advanced Glycation End Products research
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Cerebrovascular and genetic disorders
- Inflammasome and immune disorders
- Hydrogels: synthesis, properties, applications
- Ginseng Biological Effects and Applications
- Graphene research and applications
- Macrophage Migration Inhibitory Factor
- Signaling Pathways in Disease
- Genomics, phytochemicals, and oxidative stress
- Circadian rhythm and melatonin
- Cardiovascular Function and Risk Factors
- Cardiac Fibrosis and Remodeling
- Sleep and Wakefulness Research
- Breast Cancer Treatment Studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Skin Diseases and Diabetes
Nanjing Normal University
2024
China Pharmaceutical University
2024
Nanjing Medical University
2018-2023
Changzhou No.2 People's Hospital
2023
Huaian First People’s Hospital
2012-2021
Xuzhou Medical College
2020
Second People’s Hospital of Huai’an
2020
Guangxi Medical University
2017
First Affiliated Hospital of GuangXi Medical University
2017
Vascular calcification is a significant predictor of coronary heart disease events, stroke, and lower-limb amputation. Advanced glycation end-products (AGEs) play key role in the development vascular calcification. However, Nε-carboxymethyl-lysine (CML), major active ingredient heterogeneous AGEs, atherosclerotic diabetic patients underlying mechanism remain unclear. Hence, CML transmission pathway cascade were investigated present study. In vivo vitro investigations performed. study I, 45...
Circular RNA (circRNA) is a special category of non-coding that has garnered increasing attention in the exploration lipid metabolism. However, functional regulation mechanisms circRNAs obesity diseases remain unclear. By whole transcriptome sequencing, total 164 circular RNAs were found to exhibit differential expression between lean and obese individuals. RT-qPCR was used detect significant circMAPK9 individuals, it closely related BMI. Western blot, triglyceride detection, Oil Red O...
Myocardial infarction (MI), caused by continuous ischemia and hypoxia of the coronary artery, is one major causes human mortality. This study aimed to investigate role notoginsenoside R1 (NGR1) in MI therapy. In vitro vivo models were established hypoxia/reoxygenation (H/R)-treatment H9C2 cells through ligation left anterior descending artery rats, respectively. CCK-8 EdU assays performed measure cell viability proliferation, Flow cytometry terminal deoxynucleotidyl transferase dUTP nick end...
Destruction of insulin caused by the gastric microenvironment and rapid deactivation pose inevitable barriers to oral macromolecular absorption, especially for most peptide protein drugs. In this study, we developed high-density sodium alginate microspheres composed magnesium oxide urease address these challenges. These aim anchor mucus layer induce microenvironmental liquefaction, thereby enhancing retention protection insulin. The sedimentation test confirmed capability Ins/Ur/MgO@SA...
Objective . To investigate the expression and prognostic value of LncRNA FAF in patients with coronary heart disease. Patients Methods 97 disease who came to our hospital were selected as research group (RG), healthy people for physical examination during same period control (CG). The serum FAF, plasma homocysteine (HCY), lipoprotein A (Lp‐a), tumor necrosis factor α (TNF‐ ), high‐sensitivity C‐reactive protein (hsCRP) two groups detected, their correlations analyzed. Then, predictive risk...
This study aimed to investigate the role of ginsenoside Rh1 in regulating proliferation, apoptosis, and oxidative stress oxidized low-density lipoprotein (ox-LDL)-treated human vascular endothelial cells (VECs) underlying mechanisms. VECs were treated with ox-LDL generate an vitro atherosclerosis model. The effect on cell viability proliferation was examined by MTT colony formation assays, respectively, apoptosis determined flow cytometry transferase dUTP nick end-labeling assay. levels...
Abstract OBJECTIVES Acute myocardial infarction (AMI) is a leading cause of morbidity and mortality worldwide. Post-AMI cardiac remodelling closely related to the prognosis AMI. The excess inflammatory responses could promote remodelling. Tumour necrosis factor receptor-associated factor-interacting protein with forkhead-associated domain (TIFA) has been identified as nuclear (NF)-κB activator, which plays key role in activation NF-κB signalling pathway. goal this research was investigate...
Abstract Background Trace elements function as essential cofactors that are involved in various biochemical processes mammals. Autophagy is vital for nutrient supplement, which an important Zeitegber the circadian homeostasis heart. Here, we considered possibility autophagy, well cardiomyocyte clock and glycolysis interlinked. Detrimental effects were observed when cardiac system exposed to bromine containing drugs. This study investigated mechanisms of bromide on glycolytic metabolism H9C2...
To investigate the expression changes of high mobility group box-1 (HMGB-1) and tissue factor (TF) their correlation in serum sepsis rat models.30 rats were divided into sham-operated group, 15 control group. The cecal ligation puncture method was used to make animal model with abdominal infection induced by sepsis. There among which they 3 subgroups at different time points after modeling (after 6 hours, 12 24 hours). Cardiac function indicators each subgroup monitored, including heart rate...
Abstract Background Trace elements function as essential cofactors that are involved in various biochemical processes mammals. Autophagy is vital for nutrient supplement, which an important Zeitegber the circadian homeostasis heart. Here, we considered possibility autophagy, well cardiomyocyte clock and glycolysis interlinked. Detrimental effects were observed when cardiac system exposed to bromine containing drugs. This study investigated mechanisms of bromide on glycolytic metabolism H9C2...
Abstract Background: Trace elements function as essential cofactors that are involved in various biochemical processes mammals. Autophagy is vital for nutrient supplement, which an important Zeitegber the circadian homeostasis heart. Here, we considered possibility autophagy, well cardiomyocyte clock and glycolysis interlinked. Detrimental effects were observed when cardiac system exposed to bromine containing drugs. This study investigated mechanisms of bromide on glycolytic metabolism H9C2...