A5020916257- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Frailty in Older Adults
- Diet and metabolism studies
- Nutrition and Health in Aging
- Advanced Neuroimaging Techniques and Applications
- Liver Disease Diagnosis and Treatment
- Parkinson's Disease Mechanisms and Treatments
- Schizophrenia research and treatment
- Folate and B Vitamins Research
- Liver Disease and Transplantation
- Gout, Hyperuricemia, Uric Acid
- Health, Environment, Cognitive Aging
- Intensive Care Unit Cognitive Disorders
- Sleep and related disorders
- Balance, Gait, and Falls Prevention
- Bipolar Disorder and Treatment
- Advanced MRI Techniques and Applications
- Cardiovascular Health and Disease Prevention
- Neuroinflammation and Neurodegeneration Mechanisms
- Epilepsy research and treatment
- Genetic Associations and Epidemiology
- Blood properties and coagulation
- Advanced Glycation End Products research
- Abdominal vascular conditions and treatments
Qingdao Municipal Hospital
2022-2025
Qingdao University
2022-2025
Capital Medical University
2024-2025
Chengdu University of Traditional Chinese Medicine
2022
Abstract Background Blood-based biomarkers for dementia are gaining attention due to their non-invasive nature and feasibility in regular healthcare settings. Here, we explored the associations between 249 metabolites with all-cause (ACD), Alzheimer’s disease (AD), vascular (VaD) assessed predictive potential. Methods This study included 274,160 participants from UK Biobank. Cox proportional hazard models were employed investigate longitudinal dementia. The importance of these was quantified...
Abstract Inconsistent findings exist regarding the potential association between polluted air and Parkinson’s disease (PD), with unclear insights into role of inherited sensitivity. This study sought to explore link various pollutants PD risk, investigating whether genetic susceptibility modulates these associations. The population-based involved 312,009 initially PD-free participants complete genotyping data. Annual mean concentrations PM 2.5 , 10 NO 2 x were estimated, a polygenic risk...
Background C1q is a promoter of the classical pathway complement and its massive expression may be associated with development Alzheimer's disease (AD). However, relationships between major pathological challenges, including amyloid-β (Aβ) tau deposition, remain undetermined in preclinical AD phase. Objective This study aims to investigate connections plasma CSF biomarkers. Methods The cognitively intact participants (N = 1264) from Chinese Biomarker LifestylE (CABLE) were categorized into...
There is emerging evidence that diet plays a key contributor to brain health, however, limited studies focused on the association of dietary inflammatory potential with disorders. This study aimed examine inflammation disorders in UK biobank. The prospective cohort used data from 2006 2010 Biobank, median follow-up duration for different outcomes ranging between 11.37 11.38. Dietary index and Energy-adjusted [DII EDII] were assessed through plausible recalls. Outcomes included (all-cause...
Abstract INTRODUCTION To examine the extent to which positron emission tomography (PET)‐, cerebrospinal fluid (CSF)‐, and plasma‐related amyloid‐β/tau/neurodegeneration (A/T/N) biomarkers are associated with Alzheimer's disease (AD) neuropathology at autopsy. METHODS A total of 100 participants who respectively underwent antemortem biomarker measurements postmortem were included in Disease Neuroimaging Initiative (ADNI). We examined associations PET‐, CSF‐, A/T/N combinations or alone AD...
Abstract The relationship between liver dysfunction and dementia has been researched extensively but remains poorly understood. In this study, we investigate the longitudinal cross‐sectional associations function diseases risk of incident dementia, impaired cognition, brain structure abnormalities using Cox proportion hazard model linear regression model. 431 699 participants with a mean 8.65 (standard deviation [SD] 2.61) years follow‐up were included from UK Biobank; 5542 all‐cause (ACD),...
Abstract Physical frailty and genetic factors are both risk for increased dementia; nevertheless, the joint effect remains unclear. This study aimed to investigated long-term relationship between physical frailty, risk, dementia incidence. A total of 274,194 participants from UK Biobank were included. We applied Cox proportional hazards regression models estimate association risks. Among (146,574 females [53.45%]; mean age, 57.24 years), 3,353 (1.22%) new-onset events recorded. Compared...
Abstract Background Previous studies have suggested a correlation between elevated levels of β 2 -microglobulin (B2M) and cognitive impairment. However, the existing evidence is insufficient to establish conclusive relationship. This study aims analyze link plasma B2M cerebrospinal fluid (CSF) Alzheimer’s disease (AD) biomarkers cognition. Methods To track dynamics in preclinical AD, 846 cognitively healthy individuals Chinese Biomarker LifestylE (CABLE) cohort were divided into four groups...
Abstract Introduction This study aimed to assess whether biomarkers related amyloid, tau, and neurodegeneration can accurately predict Alzheimer's disease (AD) neuropathology at autopsy in early late clinical stages. Methods We included 100 participants who had ante mortem biomarker measurements underwent post neuropathological examination. Based on diagnosis, were divided into non‐dementia dementia, as or Results Amyloid positron emission tomography (PET) cerebrospinal fluid (CSF) amyloid...
Frailty is a vulnerability state increasing the risk of many adverse health outcomes, but little known about effects frailty on neuropsychiatric health.
It has been reported that the risk of Alzheimer's disease (AD) could be predicted by Australian National University Alzheimer Disease Risk Index (ANU-ADRI) scores. However, among non-demented Chinese adults, correlations ANU-ADRI scores with cerebrospinal fluid (CSF) core biomarkers and cognition remain unclear. Individuals from Biomarker LifestyLE (CABLE) study were grouped into three groups (low/intermediate/high groups) based on their The multiple linear regression models conducted to...
Abstract Though previous studies revealed the potential associations of elevated levels plasma fibrinogen with dementia, there is still limited understanding regarding influence Alzheimer's disease (AD) biomarkers on these associations. We sought to investigate interrelationships among fibrinogen, cerebrospinal fluid (CSF) AD biomarkers, and cognition in non‐demented adults. included 1996 adults from Chinese Biomarker LifestylE (CABLE) study 337 Disease Neuroimaging Initiative (ADNI)...
Abstract Liver function has been suggested as a possible factor in the progression of Alzheimer's disease (AD) development. However, association between liver and cerebrospinal fluid (CSF) levels AD biomarkers remains unclear. In this study, we analyzed data from 1687 adults without dementia Chinese Biomarker LifestylE study to investigate differences pathological clinical groups, defined by 2018 National Institute on Aging‐Alzheimer's Association Research Framework. We also examined linear...
Background: The relationship between serum uric acid (UA) and Alzheimer’s disease (AD) risk still remained ambiguous despite extensive attempts. Objective: Via the two-sample Mendelian randomization (MR) design, we aimed to examine bidirectional causal relationships of UA, gout, AD. Methods: Genetic variants AD were extracted from published genome-wide association summary statistics. inverse-variance weighted (IVW, primary method), several sensitivity methods (MR-Egger, median, mode) used...
To investigate the long-term associations of physical frailty, genetic predisposition, and their combined effect on dementia risk.
Object: The study aims to determine whether multimorbidity status is associated with cerebrospinal fluid (CSF) biomarkers for neurodegenerative disorders. Methods: A total of 827 patients were enrolled from the Parkinson’s Progression Markers Initiative (PPMI) database, including 638 early-stage disease (PD) and 189 healthy controls (HCs). Multimorbidity was evaluated based on count long-term conditions (LTCs) pattern. Using linear regression models, cross-sectional longitudinal analyses...
Epilepsy, as a chronic noncommunicable disease with recurrent seizures, may be marker of deterioration or alteration in other underlying neurological diseases. This study aimed to investigate the relationship epilepsy brain function, common disorders, and their mechanisms.
Abstract Background The prevalence of dementia among adults with diabetes represents a significant health challenge. Current risk assessment tools are not tailored to the diabetic population. This study aims develop more precise predictive models for patients using extensive blood proteomics. Method prospective cohort utilized UK Biobank data, encompassing baseline assessments from 2006 2010 and follow‐up until September 1, 2023. Excluding individuals pre‐existing dementia, we included 3015...
Cardiometabolic multimorbidity is associated with an increased risk of dementia, but the pathogenic mechanisms linking them remain largely undefined. We aimed to assess associations cardiometabolic cerebrospinal fluid (CSF) biomarkers Alzheimer's disease (AD) pathology enhance our understanding underlying and AD. This study included 1464 cognitively intact participants from Chinese Biomarker LifestylE (CABLE) database. diseases (CMD) are a group interrelated disorders such as hypertension,...