A5083610437- Epigenetics and DNA Methylation
- Genetic Associations and Epidemiology
- Gut microbiota and health
- Gestational Diabetes Research and Management
- Pregnancy and preeclampsia studies
- Bioinformatics and Genomic Networks
- Assisted Reproductive Technology and Twin Pregnancy
- Birth, Development, and Health
- Diet and metabolism studies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Dementia and Cognitive Impairment Research
- Liver Disease Diagnosis and Treatment
- Health disparities and outcomes
- Tryptophan and brain disorders
- Acute Ischemic Stroke Management
- Folate and B Vitamins Research
- Ovarian function and disorders
- Chronic Disease Management Strategies
- Pregnancy-related medical research
- Apelin-related biomedical research
- Genomics and Rare Diseases
- Fire effects on ecosystems
- Genomic variations and chromosomal abnormalities
- Vector-Borne Animal Diseases
- Health, Environment, Cognitive Aging
Fudan University
2022-2025
Huashan Hospital
2022-2025
Shanghai Center for Brain Science and Brain-Inspired Technology
2024-2025
Jishou University
2022-2024
Beijing University of Civil Engineering and Architecture
2024
Kunming University of Science and Technology
2024
Central South University
2016-2024
State Key Laboratory of Medical Neurobiology
2022-2024
University of Michigan–Ann Arbor
2024
Shanghai Medical College of Fudan University
2024
Abstract Background Blood-based biomarkers for dementia are gaining attention due to their non-invasive nature and feasibility in regular healthcare settings. Here, we explored the associations between 249 metabolites with all-cause (ACD), Alzheimer’s disease (AD), vascular (VaD) assessed predictive potential. Methods This study included 274,160 participants from UK Biobank. Cox proportional hazard models were employed investigate longitudinal dementia. The importance of these was quantified...
Large-scale proteomics studies can refine our understanding of health and disease enable precision medicine. Here, we provide a detailed atlas 2,920 plasma proteins linking to diseases (406 prevalent 660 incident) 986 health-related traits in 53,026 individuals (median follow-up: 14.8 years) from the UK Biobank, representing most comprehensive proteome profiles date. This revealed 168,100 protein-disease associations 554,488 protein-trait associations. Over 650 were shared among at least 50...
Previous studies have shown that gut microbiota (GM) and microbiota-derived metabolites are associated with gestational diabetes mellitus (GDM). However, the causal associations need to be treated caution due confounding factors reverse causation.This study obtained genetic variants from genome-wide association including GM (N = 18,340), GM-derived 7,824), GDM (5,687 cases 117,89 controls). To examine association, several methods were utilized, inverse variance weighted, maximum likelihood,...
Socioeconomic status (SES) is a critical factor in determining health outcomes and influenced by genetic environmental factors. However, our understanding of the structure SES remains incomplete. Here, we conducted large-scale exome study markers (household income, occupational status, educational attainment, social deprivation) 350,770 individuals. For rare coding variants, identified 56 significant associations gene-based collapsing tests, unveiling 7 additional SES-associated genes ( NRN1...
While increasing peripheral mechanisms related to chronic pain, the plasma proteomics profile associated with it and its prognosis remains elusive. This study utilizes 2923 proteins pain of 51 644 participants from UK Biobank finds 474 linked in six sites: head, neck or shoulder, back, stomach abdominal, hip, knee, 11 sharing across sites. The identified are largely enriched immune metabolic pathways highly expressed tissues like lungs small intestines. Phenome-wide analysis highlights...
Criminal police officers are viewed as having a very tiring and stressful job, one that is closely correlated with work disability other factors might impair quality of life. Few studies have addressed the issue health-related life (HRQoL) in this population. Thus, study aimed to assess HRQoL criminal compared general adult population identify determinants associated HRQoL. Based on cross-sectional 281 China, we used EuroQol five-dimension three-level (EQ-5D-3L) scale, Self-Rating Anxiety...
Recent studies have shown that gut microbiota (GM) is related to hypertensive disorders in pregnancy (HDP). However, the causal relationship needs be treated with caution due confounding factors and reverse causation.We obtained genetic variants from genome-wide association including GM (N = 18,340) MiBioGen Consortium as well HDP (7,686 cases/115,893 controls) specific subtypes FinnGen Consortium. Then, Inverse variance weighted, maximum likelihood, weighted median, MR-Egger, MR.RAPS...
Abstract Mounting evidence has shown that gut microbiota (GM) is related to hypertensive disorders in pregnancy (HDP), however, most studies only focused on one time point pregnancy. In this study, we conducted a nested case–control study utilizing follow-up cohort, resulting the collection of 47 HDP patients and 30 healthy controls. The GM profiles were explored using 16S rRNA sequencing at three points during diversity analysis showed no significant difference between controls, found 21...
Background Mounting evidence has demonstrated the associations between gut microbiota, microbiota-derived metabolites, and cerebrovascular diseases (CVDs). The major categories of CVD are ischemic stroke (IS), intracerebral hemorrhage (ICH), subarachnoid (SAH). However, causal relationship is still unclear. Methods A two-sample Mendelian randomization (MR) study was conducted leveraging summary data from genome-wide association studies. inverse variance-weighted, maximum likelihood, weighted...
Childhood obesity (CO) is an increasing public health issue. Mounting evidence has shown that gut microbiota (GM) closely related to CO. However, the causal association needs be treated with caution due confounding factors and reverse causation.Data were obtained from Microbiome Genome Consortium for GM as well Early Growth Genetics childhood body mass index (CBMI). Inverse variance weighted, maximum likelihood, weighted median, MR.RAPS methods applied examine association. Then replication...
Fetal macrosomia is defined as a birthweight ≥4000 g and causes harm to pregnant women fetuses. Studies reported that the maternal intestinal microbiome plays key role in establishment, growth, development of fetal microbiome. However, whether there relationship between gut microbiota remains unclear. Our study aimed identify may be related occurrence macrosomia, explore possible mechanisms by which it establish prediction model determine feasibility predicting early microbiota. We conducted...
Abstract INTRODUCTION The heritability of Alzheimer's disease (AD) is estimated to be 58%–79%. However, known genes can only partially explain the heritability. METHODS Here, we conducted gene‐based exome‐wide association study (ExWAS) rare variants and single‐variant ExWAS common variants, utilizing data 54,569 clinically diagnosed/proxy AD related dementia (ADRD) 295,421 controls from UK Biobank. RESULTS Gene‐based identified 11 predicting a higher ADRD risk, including five novel ones,...
Our previous studies have demonstrated that the urotensin (UII) and its receptor are up-regulated in skeletal muscle of mice with type II diabetes mellitus (T2DM), but significance UII insulin resistance remains unknown. The purpose this study was to investigate effect on NADPH oxidase glucose transport signaling pathways T2DM C2C12 mouse myotube cells. KK/upj-AY/J (KK) were divided into following groups: KK group, saline treatment for 2 weeks; KK+ urantide daily 30 µg/kg body weight...
Abstract Live birth is the most important concern for assisted reproductive technology (ART) patients. Therefore, in medical centre, obstetricians often need to answer following question: “What are chances that I will have a healthy baby after ART treatment?” To date, our no reference on which base this question. Our research aimed solve problem by establishing prediction models of live Between January 1, 2010, and May 2017, we conducted retrospective cohort study women undergoing treatment...
Abstract Genome-wide DNA methylation profiling have been used to find maternal CpG sites related the occurrence of gestational diabetes mellitus (GDM). However, none these differential found has verified in a larger sample. Here, our aim was evaluate whether first trimester changes target peripheral blood pregnancy women predict subsequent development GDM. This nested case–control study based upon an early follow-up cohort (ChiCTR1900020652). Target were extracted from published literature...
Previous studies have reported inconsistent associations between chronic kidney disease (CKD) and dementia.To evaluate whether CKD is a risk factor for dementia compare the performance of different measures calculating estimated glomerular filtration rate (eGFR).275,167 participants from UK Biobank were included eGFR at baseline was calculated using serum creatinine (eGFRcr), cystatin C (eGFRcys), creatinine-cystatin equations (eGFRcr-cys). Restricted cubic splines Cox regression models...
China has had explosive growth in ischemic stroke (IS) burden with significant ethnic and geographic disparities. The aim of this study was to explore the possible combination effect between gut microbiota traditional potentially modifiable risk factors for IS among two minorities (Tujia Miao) Han population. Herein, we first used 16 S rRNA sequencing compare microbial compositions 82 patients first-ever vs. normal controls (NCs) Han, Tujia, Miao people 1 May 2018 30 April 2019, from Xiangxi...
In the production of fireworks, various pollutants including particles metals and organic compounds are released into environment. Although adverse effects these air known, impact on pregnant women residing in this area remains to be determined. The aim study was examine association between maternal exposure fireworks chemicals frequency preterm birth Liuyang, China. Maternal estimated at residential district level assessed using factory density, which defined as number factories per 1000...
The aim of this study was to describe the size and shape gravida-0 uteri in infertile Chinese Han women according age, height, body mass index (BMI).Registered data obtained from Department Reproductive Medicine, Xiangya Hospital Central South University, were collected analyzed. length, width, anteroposterior diameter nonpregnant aged 20 45 years measured by transvaginal ultrasonography. Statistical analyses among different populations conducted using a 1-way analysis variance or...