A5102879780- Microbial Natural Products and Biosynthesis
- Fungal Biology and Applications
- Chemical synthesis and alkaloids
- Phytochemistry and Bioactive Compounds
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Marine Sponges and Natural Products
- Microbial Community Ecology and Physiology
- Cancer Research and Treatments
- Synthesis and biological activity
- Drug Transport and Resistance Mechanisms
- Pesticide Exposure and Toxicity
- Plant-Microbe Interactions and Immunity
- Chemical Synthesis and Analysis
- Immune cells in cancer
- Pharmacological Effects of Natural Compounds
- Nanoplatforms for cancer theranostics
- Microbial Metabolic Engineering and Bioproduction
- Veterinary medicine and infectious diseases
- HIV/AIDS drug development and treatment
- Biochemical and Molecular Research
- RNA and protein synthesis mechanisms
- HIV Research and Treatment
- Pharmacology and Obesity Treatment
- Synthetic Organic Chemistry Methods
Xiamen University
2014-2024
Lianyungang Oriental Hospital
2024
Mutations in a Plasmodium de-ubiquitinase UBP1 have been linked to antimalarial drug resistance. However, the UBP1-mediated drug-resistant mechanism remains unknown. Through selection, genetic mapping, allelic exchange, and functional characterization, here we show that simultaneous mutations of two amino acids (I1560N P2874T) yoelii can mediate high-level resistance mefloquine, lumefantrine, piperaquine. Mechanistically, double are shown impair cytoplasmic aggregation de-ubiquitinating...
Aspertetranones A–D (1–4), four new highly oxygenated putative rearranged triketide-sesquiterpenoid meroterpenes, were isolated from the marine algal-associated fungus Aspergillus sp. ZL0-1b14. On basis of a comprehensive spectroscopic analysis, planar structures aspertetranones determined to possess an unusual skeleton in terpenoid part. The relative and absolute configurations assigned on NOESY X-ray crystallography, circular dichroism spectroscopy. Compounds 1–4 evaluated for...
Ephedra-type alkaloids represent a large class of natural and synthetic phenylpropanolamine molecules with great pharmaceutical values. However, the existing methods typically rely on chemical approaches to diversify N -group modification alkaloids. Herein, we report 2-step enzymatic assembly line for creating structurally diverse replace conventional steps. We first identified new carboligase from Bacillus subtilis ( Bs AlsS, acetolactate synthase) as robust catalyst yield different...
Two new ring A ‐cleaved lanostane‐type triterpenoids, glometenoid ( 1 ) and B 2 ), together with four known steroids, (20 S ,22 E ,24 R )‐ergosta‐7,22‐dien‐3 β ,5 α ,6 ‐triol 3 (3 ,8 )‐ergosta‐6,22‐diene‐3,5,8‐triol 4 5 ‐epidioxy‐22 ‐ergosta‐6,22‐dien‐3 ‐ol ergosterol 6 were isolated from the endophytic fungus Glomerella sp. F00244. Their structures elucidated by comprehensive spectroscopic analyses of NMR MS data. antimicrobial activities evaluated against pathogenic bacteria Bacillus...
The step- and atom-efficient dimerization strategy is frequently used in nature to build structural complexity diversity. We propose the rationale features of versatile monomers that are responsible for "diversity through dimerization". Using 5-FAM-maleimide combined with a UHPLC-MS/MS-FBMN workflow, we successfully identified diverse set dimeric natural products from fungus Panus rudis F01315, which all four complex 4'5-ring scaffolds derived one monomeric epoxyquinol endowed functional
A synthesis program for structurally complex macrocycles is very challenging. Herein, we propose a biosynthesis pathway of the pyranylated cyclodepsipeptide verucopeptin to make enough supply and diversify by genetic manipulation one-step semisynthesis. The relies on intrinsic reactivity interchangeable hemiketal pyrane opened keto along with adjacent alkene. Biological evaluation verucopeptin-oriented analogs delivers potent AMP-activated protein kinase (AMPK) agonist, antibacterial agent,...
Ephedra-type alkaloids represent a large class of natural and synthetic phenylpropanolamine molecules with great pharmaceutical values. However, the existing methods typically reply on chemical approaches to diversify N-group modification alkaloids. Herein, we report two-step enzymatic assembly line for creating structurally diverse alkaloids, replace conventional steps. We first identified new carboligase from Bacillus subtilis (BsAlsS, acetolactate synthase) as robust catalyst yield...
Bacterial membrane vesicles (BMVs) are crucial biological vehicles for facilitating interspecies and interkingdom interactions. However, the extent mechanisms of BMV involvement in bacterial-algal communication remain elusive. This study provides evidence BMVs delivering cargos to targeted microalgae. Membrane (MVs) from Chitinimonas prasina LY03 demonstrated an algicidal profile similar strain LY03. Further investigation revealed Tambjamine LY2, effective compound, selectively packaged into...
Abstract Acquiring detailed spatial information about intratumor microbiota in situ is challenging, which leaves 3D distributions of within entire tumors largely unexplored. Here, a modified iDISCO‐CUBIC tissue clearing and D‐amino acid microbiome labeling‐based (miCDaL) strategy are proposed, that integrates labeling, clearing, whole‐mount imaging to enable visualization indigenous microbiota. Leveraging resolution centimeter‐scale depth, the biogeography successfully charted across various...
Homo- or heterodimeric compounds that affect dimeric protein function through interaction between monomeric moieties and subunits can serve as valuable sources of potent selective drug candidates. Here, we screened an in-house natural product collection, panepocyclinol A (PecA) emerged a STAT3 inhibitor with profound anti-tumor efficacy. Through cross-linking C712/C718 residues in separate monomers two distinct Michael receptors, PecA inhibits DNA binding affinity transcription activity....
Objective: To analyze the efficacy of reduced glutathione (GSH) in emergency treatment patients with organophosphorus pesticide poisoning (AOPP). Methods: A total 100 AOPP admitted to department between January 2022 and 2024 were selected randomly divided into two groups. The observation group (n = 50) received GSH combined conventional treatment, while reference alone. overall efficacy, serum indicators, adverse reaction rates compared. Results: exhibited a higher compared (P < 0.05)....
Abstract isolation, structure elucidation, antimicrobial and cytotoxic activities of two new triterpenoids, called glometenoid A (I) B (II), together with four known ergostane‐type steroids