Lin Shen

ORCID: 0000-0002-9147-592X
Publications
Citations
Views
---
Saved
---
About
Contact & Profiles
Research Areas
  • Systemic Sclerosis and Related Diseases
  • Advanced biosensing and bioanalysis techniques
  • Reproductive System and Pregnancy
  • Birth, Development, and Health
  • Pregnancy and preeclampsia studies
  • Mast cells and histamine
  • Microbial Fuel Cells and Bioremediation
  • Advanced Nanomaterials in Catalysis
  • Connective Tissue Growth Factor Research
  • Adipokines, Inflammation, and Metabolic Diseases
  • Mine drainage and remediation techniques
  • Ear and Head Tumors
  • Educational Reforms and Innovations
  • Regulation of Appetite and Obesity
  • Drug-Induced Adverse Reactions
  • Blood properties and coagulation
  • Endoplasmic Reticulum Stress and Disease
  • Advancements in Transdermal Drug Delivery
  • interferon and immune responses
  • Autoimmune Bullous Skin Diseases
  • Single-cell and spatial transcriptomics
  • Climate Change and Health Impacts
  • Obesity, Physical Activity, Diet
  • Anaerobic Digestion and Biogas Production
  • Pregnancy and Medication Impact

Chinese Academy of Sciences
2025

First Affiliated Hospital of Nanchang University
2025

Guangzhou Institute of Geochemistry
2025

Guangdong Academy of Sciences
2025

University of Chinese Academy of Sciences
2025

Nanchang University
2025

First Affiliated Hospital of Jiangxi Medical College
2025

Sun Yat-sen University
2020-2024

Shaanxi Provincial People's Hospital
2024

Shanxi Medical University
2024

Our previous study suggested that SEB exposure in pregnant rats could lead to the change of T cells subpopulation both peripheral blood and thymus offspring rats. However, rarely is known about influence on cell spleens was intravenously administered at gestational day 16 this study. The percentages, vivo vitro responses CD4 CD8 were investigated with flow cytometry. prenatal obviously increased splenic percentages neonates adult rats, reduced fifth After re-stimulated or vitro, stimulation...

10.1186/s12866-016-0921-2 article EN cc-by BMC Microbiology 2017-01-03

Periodontitis is a chronic inflammatory disease caused by plaque. In order to remove pathogens and promote tissue repair, the following steps need be taken simultaneously: localizing diseased area, improving anaerobic microenvironment, as well addressing anti-inflammatory osteogenic needs. This study aims address these issues developing responsive near-infrared-IIb nanozyme system (DMUP), assembled from lanthanide-doped down-converted nanoparticles multi-enzymatically active nanozyme. DMUP...

10.1186/s12951-025-03270-9 article EN cc-by-nc-nd Journal of Nanobiotechnology 2025-03-08

Carbonaceous materials, including activated carbon and pyrolytic carbon, have been recognized for about over a decade as effective electron shuttles or conductive materials in promoting microbial Fe(III) mineral reduction. However, recent studies reveal inhibitory effects, sparking debates their overall impact. We hypothesized that the physical contact between bacteria is an overlooked yet critical factor determining whether promotes inhibits Using systems containing Shewanella oneidensis...

10.1021/acs.est.4c14024 article EN Environmental Science & Technology 2025-04-10

Abstract RIG‐I is associated with the occurrence and development of many tumors. However, role in radiotherapy chemotherapy NPC has not been reported to date. In our study, expression was significantly reduced chemoradiotherapy‐resistant tissues cells compared that therapy‐sensitive cells. increased nonresistant cells, including CNE1 CNE2, a dose‐dependent manner increasing drug concentration or dose. overexpression promoted sensitivity leading cellular apoptosis proapoptotic factors BAX...

10.1002/cam4.2501 article EN cc-by Cancer Medicine 2019-08-28

To determine the alteration of peripheral T and B cell subsets in patients with systemic sclerosis (SSc) to evaluate their correlation progression SSc. We recruited 47 SSc 45 healthy controls (HCs) this study. Demographic clinical data were then collected. Flow cytometry was used detect proportions 44 different circulating blood. The proportion total cells (p = .043) decreased patients, together similar frequencies cells, CD4+ CD8+ both groups. Several differed significantly between these...

10.1111/1756-185x.15145 article EN International Journal of Rheumatic Diseases 2024-04-01

Anti-cancer therapy is crucial in cancer prevention and anti-cancer, thus, highly sensitive methods for detecting biomarkers are essential early diagnosis. Herein, an electrochemical aptamer biosensor based on the CRISPR-Cas12a system was constructed detection of tumor biomarker MUC1 mucin. The sensitivity significantly prompted by enzyme-catalyzed signal amplification, selectivity improved dual recognition to crRNA-Cas12a aptamer. Glucose oxidase (GOD) loaded surface magnetic Fe

10.1039/d4an00595c article EN The Analyst 2024-01-01

Venous thromboembolism (VTE) is a substantial contributor to the global burden of disease. Observational studies have suggested that leisure sedentary behaviours (LSB) are related risk VTE; however, causal role LSB in VTE remains unclear.

10.1186/s12872-023-03395-5 article EN cc-by BMC Cardiovascular Disorders 2023-07-18

In the production of fireworks, various pollutants including particles metals and organic compounds are released into environment. Although adverse effects these air known, impact on pregnant women residing in this area remains to be determined. The aim study was examine association between maternal exposure fireworks chemicals frequency preterm birth Liuyang, China. Maternal estimated at residential district level assessed using factory density, which defined as number factories per 1000...

10.1080/15287394.2017.1415579 article EN Journal of Toxicology and Environmental Health 2018-01-16

The effects of α - tocopherol nicotinate on hemorheological properties and retinal microcirculation in non-insulin dependent diabetes mellitus (NIDDM) were investigated. Seven female NIDDM with retinopathy orally administered nicotinat

10.3233/ch-1995-15509 article EN Clinical Hemorheology and Microcirculation 1995-01-01

This Letter reports the first measurement of oscillation amplitude and frequency reactor antineutrinos at Daya Bay via neutron capture on hydrogen using 1958 days data. With over 3.6 million signal candidates, an optimized candidate selection, improved treatment backgrounds efficiencies, refined energy calibration, response model for capture-on-hydrogen sensitive region, relative $\overline{\nu}_{e}$ rates spectra variation among near far detectors gives $\mathrm{sin}^22\theta_{13} =...

10.48550/arxiv.2406.01007 preprint EN arXiv (Cornell University) 2024-06-03

<h3>Background:</h3> Primary Sjögren's syndrome (pSS) is a heterogeneous systemic autoimmune disease marked with varied clinical manifestations and diversified treatment response, potentially due to different pathogeneses among patients. <h3>Objectives:</h3> Our study aimed clarify the etiology molecular variation of target organ, salivary glands (SGs), in pSS by stratifying them into distinguishable subgroups, which could inform choices pSS. <h3>Methods:</h3> Large-scale transcriptomic...

10.1136/annrheumdis-2024-eular.4701 article EN Annals of the Rheumatic Diseases 2024-06-01

Rationale: Stevens–Johnson syndrome (SJS) is a rare but severe skin-mucosal reaction with high mortality rate. It characterized by sudden, painful blistering lesions on the skin, often accompanied fever and systemic toxicity. Lesions typically appear dorsal surfaces of hands, feet, forearms, legs, soles feet. They can also affect conjunctiva, oral mucosa, labial vaginal mucosa. Patients may experience complications such as pneumonia, comorbidities, liver renal failure. Patient concerns: A...

10.1097/md.0000000000039531 article EN cc-by-nc Medicine 2024-09-06

Cancer can educate platelets by altering transcriptome profiles. However, the exact education mechanism remains unclear, and variability of tumor-educated platelet (TEP) has not been investigated. In this study, we aimed to build a stratification system for TEP based on machine learning (ML) data-driven patterns This study included samples from 1,628 cancer participants European United States populations, including 18 different most prevalent types cancer. Gaussian mixture model (GMM) was...

10.1016/j.fmre.2023.09.004 article EN cc-by Fundamental Research 2023-11-01

To investigate the change of blood pressure in patients with hypertensive disorders pregnancy after delivery and risk factors.In a retrospective cohort study, we collected subjects from villages towns Liuyang by cluster sampling method. Before enrolling this cohort, all had established health records January 2010 to December 2011. We medical maternal care manuals as our data materials, focusing on well related features. compared differences recovery rate postpartum different kinds antenatal...

10.11817/j.issn.1672-7347.2014.03.003 article EN PubMed 2014-03-01
Coming Soon ...