A5001557249- Electrospun Nanofibers in Biomedical Applications
- Silk-based biomaterials and applications
- Nanoparticle-Based Drug Delivery
- Blood properties and coagulation
- Polymer Surface Interaction Studies
- Advanced Drug Delivery Systems
- Hemoglobin structure and function
- Bone Tissue Engineering Materials
- Tissue Engineering and Regenerative Medicine
- Protease and Inhibitor Mechanisms
- RNA Interference and Gene Delivery
- Acoustic Wave Resonator Technologies
- Advanced Proteomics Techniques and Applications
- Erythrocyte Function and Pathophysiology
- Cell Adhesion Molecules Research
- Hydrogels: synthesis, properties, applications
- Blood transfusion and management
- Advanced Sensor and Energy Harvesting Materials
- Diabetes, Cardiovascular Risks, and Lipoproteins
- biodegradable polymer synthesis and properties
- Peptidase Inhibition and Analysis
- Hemoglobinopathies and Related Disorders
- Retinal Diseases and Treatments
- Immune Response and Inflammation
- Nerve injury and regeneration
National Yang Ming Chiao Tung University
2014-2024
National Yang Ming University Hospital
2017-2021
Chung Yuan Christian University
2000-2020
University of Oklahoma
1991-2016
National Yunlin University of Science and Technology
2005-2014
Taipei Medical University
2012
University of Science and Technology
2011
Korea University of Science and Technology
2011
Yulin University
2011
National Taiwan University
1999-2004
Ischemia/reperfusion (I/R) injury causes the generation of many ROS such as H2O2 and leads to vascular thrombosis, which tissue damage.In this investigation, poly (lactideco-glycolide) (PLGA)-based nanoparticles are used for their anticoagulant antioxidant properties in therapy.Both heparin glutathione entrapped on PLGA-stearylamine by layer-by-layer interactions.The drug release rate is successfully controlled with only 10.3% released after 96 hours. An H2O2-responsive platform also...
Abstract Bone is a flexible and electro active tissue that vulnerable to various traumatic injuries. The self-healing of damaged bone towards reconstruction limited due the lack proper niche compliances. Nevertheless, classical grafting techniques like autograft/allograft for repair pose challenges bacterial infections donor-site morbidity with unsatisfactory outcomes. use appropriate biomaterial osteogenic potential can meet these challenges. In this regard, bioactive glass ceramics widely...
Abstract: To improve endothelial cell adhesion and growth on the surface of polyethylene glycol modified polyurethane (PU‐PEG), adhesive peptide Gly‐Arg‐Gly‐Asp (GRGD) was photochemically grafted to surface. The GRGD‐N‐Succinimidyl‐6‐[4′‐azido‐2′‐nitrophenylamino]hexanoate (SANPAH) a PU‐PEG performed by adsorption subsequent ultraviolet irradiation. Fourier transform infrared spectra (FTIR) electron spectroscopy for chemical analysis (ESCA) confirmed GRGD form PU‐PEG‐GRGD composition...
Silk fibroin (SF) and hyaluronic acid (HA) were crosslinked by horseradish peroxidase (HRP)/H2O2, 1,4-Butanediol di-glycidyl ether (BDDE), respectively, to produce HA/SF-IPN (interpenetration network) (HS-IPN) hydrogels. HS-IPN hydrogels consisted of a SF strain with high content tyrosine (e.g., A) increased viscoelastic modules compared those low contents B C). Increasing the quantities in HS7-IPN weight ratio HA/SF, 5:7) In addition, mean pores size scaffolds model around 38.96 ± 5.05 μm...
The purpose of this study was to develop the pathway silk fibroin (SF) biopolymer surface induced cell membrane protein activation. Fibroblasts were used as an experimental model evaluate responses cellular proteins by material using a mass spectrometry-based profiling system. covered multiwalled carbon nanotubes (CNTs) and SF increase area, enhance adhesion biopolymer, promote rate proliferation. amount adhered fibroblasts on CNTs/SF electrodes quartz crystal microbalance (QCM) greatly...
Hyaluronic acid/silk fibroin (HA/SF or HS) hydrogels with remarkable mechanical characteristics have been reported as tissue engineering biomaterials. Herein, the addition of dopamine/polydopamine (DA/PDA) to HS develop multifunctional HA/PDA/SF (or HDS) for delivery drugs such N-acetyl-L-cysteine (NAC) from nasal brain is examined. DA-dependent functions HDS highly adhesive forces, photothermal response (PTR) effects generated by near infrared (NIR) irradiation, and anti-oxidative were...
Abstract To explore the application of PCL for engineering soft tissues, surface was first embedded in an amphiphilic moiety and then grafted with RGD peptide to enhance growth rate human endothelial cells (HUVEC) on surface. graft cell‐adhesive surface, etched by selected solvent only nanometer‐scale disturbance, simultaneously DSPE‐PEG [di‐stearoyl‐phosphatidyl‐ethanolamine‐methoxy‐poly (ethylene glycol)] moiety. Then PCL‐PEG photochemically GRGD form PCL‐PEG‐RGD modified surfaces were...
Abstract: To improve the adhesion and growth of endothelial cells on chitosan, different concentrations cell adhesive peptide, Gly‐Arg‐Gly‐Asp (GRGD), were photochemically grafted to its surface. After GRGD‐SANPAH (N‐Succinimidyl‐6‐4′‐azido‐2′‐nitrophenylamino]—hexanoate) solutions formed, they chitosan surfaces by performing surface adsorption peptide subsequent ultraviolet (UV) irradiation induce photoreaction. The efficiency for GRGD was higher than 80%, as semiquantitatively analyzed a...
Abstract Accelerated thrombolysis by pressure‐driven permeation has been demonstrated in vitro and vivo animal models using plasminogen activators (PAs) encapsulated liposomes or PEG microparticles. Recent reports have also described acceleration of tissue type PA (t‐PA) PLGA nanoparticles (NPs) coated with chitosan (CS) CS‐GRGD interactions between the NPs blood clots. However, through dissolving patterns aforementioned microparticles NPs, which may be clinically relevant to recovery status...