A5086013643- SARS-CoV-2 and COVID-19 Research
- Mass Spectrometry Techniques and Applications
- Acoustic Wave Resonator Technologies
- Alzheimer's disease research and treatments
- Epigenetics and DNA Methylation
- Silk-based biomaterials and applications
- Radiomics and Machine Learning in Medical Imaging
- Amino Acid Enzymes and Metabolism
- Advanced Proteomics Techniques and Applications
- Medical Imaging Techniques and Applications
- Cancer Research and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Molecular Junctions and Nanostructures
- Liver Disease Diagnosis and Treatment
- Heparin-Induced Thrombocytopenia and Thrombosis
- Cardiac Imaging and Diagnostics
- Protein Degradation and Inhibitors
- Advanced X-ray and CT Imaging
- Lymphadenopathy Diagnosis and Analysis
- PI3K/AKT/mTOR signaling in cancer
- Folate and B Vitamins Research
- TGF-β signaling in diseases
- Supramolecular Self-Assembly in Materials
- RNA Interference and Gene Delivery
- Phytochemicals and Antioxidant Activities
Kaohsiung Medical University
2008-2024
Kaohsiung Medical University Chung-Ho Memorial Hospital
2014-2024
Fifth Hospital of Shijiazhuang
2024
Kaohsiung Veterans General Hospital
2019-2023
Min-Hwei College of Health Care Management
2021-2023
Korea Institute of Toxicology
2023
Sun Yat-sen University
2021
Taipei Medical University
2019-2020
National Health Research Institutes
2019-2020
Institute of Biological Chemistry, Academia Sinica
2019
Canine distemper (CD) is one of the most contagious and lethal viral diseases in dogs. Despite widespread use vaccines, prevalence CD virus (CDV) has increased at an alarming rate recent years. In this phylodynamic study, we investigated spatiotemporal modes dispersal, demographic trends, effectiveness vaccines for CDV. A total 188 full-length CDV hemagglutinin (H) gene sequences dataset were subjected to recombination analysis, including seven from modified live vaccine (MLV) strains 12...
It is becoming increasingly evident that certain phytochemicals possess cancer chemopreventive properties. In this study, the antiproliferative activity of extracts from different parts jaboticaba ( Myrciaria cauliflora ) plant was evaluated for its effect on human oral carcinoma cell lines. The cytotoxicities various extract concentrations were examined and 50% maximal inhibitory concentration (IC 50 determined. Water seeds showed concentration-dependent effects. Annexin V/propidium iodide...
Abstract High somatic cell counts in milk caused by mastitis significantly influence the quality of and result substantial annual economic loss. This study evaluated beneficial effects melatonin (MT) on count (SCC) cows. To examine SCC, one hundred twenty cows were divided into four groups based SCC. In each group, half treated with (S.C.). Melatonin treatment reduced explore potential mechanism, 20 relatively high SCC selected to evaluate biochemical immunological profiles their blood after...
Chloroquine (CQ) and its derivative, hydroxychloroquine (HCQ), have attracted wide attention for treating coronavirus disease 2019 (COVID-19). However, conflicting outcomes been found in COVID-19 clinical trials after treatment with CQ or HCQ. To date, it remains uncertain whether HCQ are beneficial antiviral drugs combating COVID-19. We performed a systematic review to depict the efficacy of The guidelines PRISMA were used conduct this review. searched through articles from PubMed, Web...
Alzheimer's disease (AD) is the most common cause of dementia in late life. It difficult to precisely diagnose AD at early stages, making biomarker search essential for further developments. The objective this study was identify protein biomarkers associated with aluminum ions toxicity (AD-like toxicity) a human neuroblastoma cell model, SH-SY5Y and assess potential prevention by NAP (NAPVSIPQ). Complete proteomic techniques were implemented. Four proteins identified as up-regulated ion...
Mass vaccination against coronavirus disease 2019 (COVID-19) is a global health strategy to control the COVID-19 pandemic. With increasing number of vaccinations, vaccine-associated lymphadenopathy (C19-VAL) has been frequently reported. Current findings emphasize characteristics C19-VAL. The mechanism C19-VAL complicated explore. Accumulated reports separately show that incidence associated with receiver age and gender, reactive change within lymph nodes (LN), etc. We constructed systematic...
The purpose of this study was to develop the pathway silk fibroin (SF) biopolymer surface induced cell membrane protein activation. Fibroblasts were used as an experimental model evaluate responses cellular proteins by material using a mass spectrometry-based profiling system. covered multiwalled carbon nanotubes (CNTs) and SF increase area, enhance adhesion biopolymer, promote rate proliferation. amount adhered fibroblasts on CNTs/SF electrodes quartz crystal microbalance (QCM) greatly...
Since countries commenced COVID-19 vaccination around the world, many vaccine-related adverse effects have been reported. Among them, short-term memory loss with autoimmune encephalitis (AE) was reported as a rare effect. case numbers are limited, this brief report may draw attention of medical community to uncommon effect and serve reference for future vaccine improvement. However, given high risk outcomes when infected SARS-CoV-2 clearly favorable safety/tolerability profile existing...
Increasing human Adenovirus (HAdV) infections complicated with acute respiratory distress syndrome (ARDS) even fatal outcome were reported in immunocompetent adolescent and adult patients. Here, we characterized the cytokine/chemokine expression profiles of patients ARDS during HAdV infection identified biomarkers for disease severity/progression. Forty-eight cytokines/chemokines plasma samples from 19 HAdV-infected (ten ARDS) measured analyzed combination clinical indices. Immunocompetent...
Hepatitis C virus (HCV) infection can cause permanent liver damage and hepatocellular carcinoma, deaths related to HCV have recently increased. Chronic is often undiagnosed such that the remains infective transmissible. Identifying early essential for limiting its spread, but distinguishing individuals who require further tests very challenging. Besides identifying high-risk populations, an optimal subset of indices routine examination needed identify screening candidates. Therefore, this...
Abstract Characterized with a high recurrence rate and low detection rate, prevention is the best approach to reduce mortality in hepatocellular carcinoma (HCC). The overexpression of Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 2 (PREX2) observed various tumors, including HCC; frequent PREX2 mutations melanoma are associated invasiveness. We sought identify somatic functional changes mutational signatures PREX2. Genomic DNA sequencing was performed 68 HCC samples...
Hepatocellular carcinoma (HCC) is among the ten most commonly diagnosed cancers and fourth leading cause of cancer-related death. Patients with hepatitis B virus (HBV) infection are prone to developing chronic liver diseases (i.e., fibrosis cirrhosis), HBV X antigen plays an important role in development HCC. The difficulty detecting HCC at early stages one main reasons that death rate approximates incidence rate. regulators controlling downstream protein expression from unclear. Mass...
The cell responses to biopolymer surface at the early adhesion stages can be critical for survival. purpose of this research was assess formation hyaluronic acid (HA) surface, fibroblasts were used as an experimental model evaluate cellular proteins induced by materials using a mass spectrometry-based profiling system. Surfaces covered multi-walled carbon nanotubes (CNT), chitosan (CS), and HA increase area, enhance promote rate proliferation. amount adhered on CNT/CS/HA electrodes quartz...
Background: angiotensin-converting enzyme (ACE) gene insertion/deletion (indel) polymorphism is considered a biomarker for Alzheimer's disease (AD). However, the associations of ACE and protein level to AD are undetermined among Taiwanese.
Technetium-99 (<sup>99</sup>Tc) is a key nuclide, produced by the fission of uranium-235 (<sup>235</sup>U) and plutonium-239 (<sup>239</sup>Pu), through cascade decay process, one kind target element in environmental analysis due to its long half-life (<italic>t</italic><sub>1/2</sub> = 2.1 × 10<sup>5</sup> years).