A5020901564- Asthma and respiratory diseases
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Cholinesterase and Neurodegenerative Diseases
- Olfactory and Sensory Function Studies
- Health, Environment, Cognitive Aging
- Autophagy in Disease and Therapy
- Nicotinic Acetylcholine Receptors Study
- Neurological Disease Mechanisms and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- RNA modifications and cancer
- Functional Brain Connectivity Studies
- Acute Myocardial Infarction Research
- Bioactive natural compounds
- Berberine and alkaloids research
- Ion Channels and Receptors
- Grey System Theory Applications
- Forecasting Techniques and Applications
- Inflammation biomarkers and pathways
- Poxvirus research and outbreaks
- Shoulder and Clavicle Injuries
- Cancer, Stress, Anesthesia, and Immune Response
- Trace Elements in Health
- Curcumin's Biomedical Applications
- Synthesis of Indole Derivatives
Qingdao University
2024-2025
Qingdao Municipal Hospital
2024-2025
University of Freiburg
2023-2024
Shaoguan University
2024
Jinan University
2005-2024
Guangdong University of Technology
2021-2024
Air Force Medical University
2019
University of Hong Kong - Shenzhen Hospital
2018
University of Hong Kong
2018
Guangdong Pharmaceutical University
2017
Racemic salbutamol ((RS)-sal), which consist of the same amount (R)-sal and (S)-sal, has been used for asthma COPD due to its bronchodilation effect. However, effect on repeated dextran sulfate sodium (DSS)-induced chronic colitis not yet investigated. In this study evaluated potential (R)-, (S)-, (RS)-sal in mice with DSS-induced investigated underlying mechanisms. Here, we verified that was significantly attenuated by (R)-sal, evidenced notably mitigated body weight loss, disease activity...
(1) Background: Differentiated podocytes are particularly vulnerable to oxidative stress and cellular waste products. The disease-related loss of postmitotic is a direct indicator renal disease progression aging. Podocytes use highly specific regulated networks autophagy endocytosis that counteract the increasing number damaged protein aggregates help maintain homeostasis. Here, we demonstrate ARFIP2 regulator mitophagy in both vitro vivo. (2) Methods: In recent molecular regulatory network...
This study investigates the associations between modified triglyceride-glucose (TyG) indices and triglyceride-to-high-density lipoprotein (TG/HDL) ratio, which are recognized as simple surrogate indicators of insulin resistance, with all-cause cause-specific mortality. A cohort 410,515 participants from UK Biobank was analyzed. Cox proportional hazard models restricted cubic spline regression analyses were employed to examine relationships TyG index, TyG-body mass index (TyG-BMI), TyG-waist...
The relationship between the low-density lipoprotein/high-density lipoprotein (LDL/HDL) ratio, an indicator of lipid metabolism and assessment cardiovascular disease (CVD) risk, Alzheimer's (AD) is unclear. Multivariable Cox regression analyses were used to examine association LDL/HDL ratio risk AD. Multiple linear mixed effects models assess associations cognitive function, AD pathology, brain structure. Mediation examined pathology's potential mediating role cognition. Higher correlated...
The dietary index for gut microbiota was associated with a reduced risk of stroke, inflammation partially mediating this association.
Abstract BiPO 4 ‐coated LiNi 0.8 Co 0.15 Al 0.05 O 2 (NCA) cathode material is prepared by a precipitation method. Scanning electron microscope and X‐ray diffraction results demonstrate that the morphology structure of NCA are not affected layer. Transmission microscopy analysis indicates thickness layer about 10 nm. Electrochemical properties investigated in different voltage ranges. The show wider charge discharge cut‐off is, larger specific capacity with initial 325.0 mAh g −1 within...
Background: Patients with transient ischemic attack (TIA) or stroke demonstrate an increased risk of cognitive dysfunction. Accumulating evidence indicates that cerebrovascular disease (ICVD) may interact the amyloid/tau/neurodegeneration (AT[N]) biomarkers to promote dementia. However, precise pathological mechanisms remain be fully characterized. Objective: To elucidate interrelationships among ICVD, ATN in cerebrospinal fluid (CSF), and cognition. Methods: A total 2524 participants were...
The nanodrug delivery system-based nasal spray (NDDS-NS) can bypass the blood-brain barrier and deliver drugs directly to brain, offering unparalleled advantages in treatment of central nervous system (CNS) diseases. However, current design NNDS-NS is excessively focused on mucosal absorption while neglecting impact deposition nose-to-brain drug delivery, resulting an unsatisfactory efficiency. In this study, effect dispersion medium viscosity NDDS-NS was elucidated. optimized formulation F5...
The purple sweet potato, Ipomoea batatas, belongs to the family Convolvulaceae. It is one of most widely consumed tubers in Asia and found many dishes. Many people with diabetes eat potato help reduce blood glucose China.To predict ultrasonic conditions for getting optimal vitro antioxidant antiglycated activity extracted polysaccharides from (I. batatas) tubers, artificial neural network (ANN) regression models was used this study.The quantified by evaluating hydroxyl radical scavenging...
Background Patients with lung adenocarcinoma (LUAD) often develop a poor prognosis. Currently, researches on prognostic and immunotherapeutic capacity of aneuploidy-related genes in LUAD are limited. Methods Genes related to aneuploidy were screened based bulk RNA sequencing data from public databases using Spearman method. Next, univariate Cox Lasso regression analyses performed establish an riskscore (ARS) model. Results derived bioinformatics analysis further validated cellular...
Introduction: The purpose of this study was to test whether local filling a novel strontium-containing hydroxyapatite (Sr-HA) bone cement can augment the fixation locking plate system in cadaveric proximal humeral facture model. Materials and Methods: Twelve pairs formalin-treated humeri were used. One side each pair for cemented group, while other control group. mineral density (BMD) samples tested. A 3-part model created then reduced fixed by system. In most 4 screw holes filled with 0.5...
Butyrylcholinesterase (BChE) is detected in plaques preferentially Alzheimer’s disease (AD) and may be associated with stress disorders. However, the physiological function of BChE central nervous system remains to further investigated. knockout (KO) mice wild-type (WT) orally or intranasal administration (R)-bambuterol were used explore effect on behavior changes. a specific reversible inhibitor BChE. The changes evaluated compared among 3–10 month old mice. Our finding showed that KO...
The form of selenium appears to be important for preventing cancer in humans. Here, we evaluated levels the serum and bone tissue samples from osteosarcoma patients using atomic absorption spectrometry. vitro effects Se-methylselenocysteine (Se-MSC) on growth, cell cycle status, apoptosis cells were assessed WST-1 assay, Hoechst 33342/propidium iodide staining, flow cytometry, respectively. In cases, mean normal 0.08 mg/kg 0.03 mg/kg, respectively (P < 0.05). Serum non-osteosarcoma cases...
The cutaneous symptom of the paraneoplastic erythroderma can be only a malignancy. Although many cases associated with malignancies have been reported, pathogenesis cancer related is still unclear. Herein we presented patient large cell neuroendocrine carcinoma (LCNEC) lung and contemporary severe erythroderma. suffered from skin erythema scaling all over body lesions recovered completely after 3 weeks surgery. Strong expression neuron-specific enolase (NSE, 2+ positive) was found in both...