A5101562313- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- RNA modifications and cancer
- Intracranial Aneurysms: Treatment and Complications
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Cancer Mechanisms and Therapy
- SARS-CoV-2 and COVID-19 Research
- Circular RNAs in diseases
- Moyamoya disease diagnosis and treatment
- Long-Term Effects of COVID-19
- Cerebrovascular and Carotid Artery Diseases
- Hematopoietic Stem Cell Transplantation
- COVID-19 Clinical Research Studies
- Breast Cancer Treatment Studies
- Ferroptosis and cancer prognosis
- Gastric Cancer Management and Outcomes
- Cancer Cells and Metastasis
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Genomics and Diagnostics
- Chronic Lymphocytic Leukemia Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Angiogenesis and VEGF in Cancer
- Head and Neck Cancer Studies
- PI3K/AKT/mTOR signaling in cancer
First Affiliated Hospital of Wenzhou Medical University
2015-2025
Longgang Central Hospital
2025
Wenzhou Medical University
2015-2025
Shenzhen Institutes of Advanced Technology
2023-2025
University of Chinese Academy of Sciences
2023-2025
Chinese Academy of Sciences
2025
Changchun University of Science and Technology
2020-2024
Renji Hospital
2024
Shanghai Jiao Tong University
2017-2024
China Medical University
2020
The CD44 isoform containing variant exon v6 (CD44v6) plays an important role in the progression, metastasis, and prognosis of colorectal cancer (CRC). Recently, it was found that CD44v6 is involved acquired drug resistance. This study aimed to investigate molecular mechanism resistance CRC cells chemotherapy. A stable overexpression model SW480 established via lentiviral transduction. chemosensitivity 5-fluorouracil (5-FU) oxaliplatin (L-OHP) determined by cell counting kit (CCK)-8, lactate...
MAPT-AS1, a long non-coding RNA, has not been reported in any previous research about its function cancers. In this study, we investigated the role of MAPT-AS1 progression and paclitaxel resistance breast cancer, regulation between natural comparable sense transcripts MAPT.We analysed cancer patients' clinical information explored by gain- loss-of assays vitro vivo. The MAPT was confirmed gene expression analysis rescue assays. To verify hypothesis that might form duplex structure, performed...
Background: Hypocalcemia is one of the most common postoperative complications following thyroid surgery in clinical practice. The occurrence hypocalcemia mainly attributed to hypoparathyroidism when parathyroid glands are devascularized, injured, or dissected during surgery. aim this study was analyze risk factors for and thyroidectomy. Patients methods: A total 278 patients who underwent were analyzed retrospectively. Univariate analysis multivariable logistic regression performed discover...
Breast cancer is the most common malignancy in women and underlying mechanism of breast cell metastasis still far from uncover. Integrin subunit alpha 7 (ITGA7) a functioning protein. It has been detected many malignancies. But function ITGA7 not clear. Our aim to explore expression its role cancer.Real-time PCR was performed determine BC tissues normal adjacent tissues. The specific functions lines (MDA-MB-231 BT-549) transfected with small interfering RNA were determined through migration,...
Psoriasis is an inflammatory skin disease mediated by multiple immune cells, including T macrophages, and dendritic which exhibit complex pathologies limited clinical treatment. Here, we found that salt‐inducible kinase 1 (SIK1) was upregulated in the imiquimod (IMQ)‐induced psoriasis mouse model. This increment may be due to a higher level of interleukin‐17, promoted expression SIK1 keratinocytes. Inhibition activity using small molecular inhibitor (HG‐9‐91‐01 or YKL‐06‐062) dramatically...
The implementation of COVID-19 policy and the rapid development SARS-CoV-2 vaccines in early pandemic significantly contained numerous outbreaks reduced severity mortality COVID-19. However, population immunity induced by existing was insufficient to prevent outbreaks. host wide spread Omicron variants its influence on emerging are attracting broad attention. In this study, a clinical data analysis patients indicated that pre-vaccination inflammatory responses mitigated cases caused natural...
For women, breast cancer is the most commonly diagnosed and leading cause of women deaths due to cancer. In recent years, increasing long noncoding RNA (lncRNA) has been discovered be related tumorigenesis, progression, prognosis. FOXD3‐AS1 a lncRNA identified as cancer‐promoting gene in glioma. By analysing expression The Cancer Genome Atlas (TCGA) database, we found that significantly high tumour comparing with normal tissue. And patients low had greater survival probability, smaller size,...
Non–small cell lung cancer (NSCLC) accounts for approximately 80–85% of all cancers and is usually diagnosed at an advanced stage with poor prognosis. Targeted therapy has produced unprecedented outcomes in patients NSCLC as a number oncogenic drivers have been found. Crizotinib, selective small-molecule inhibitor, widely used the treatment ALK gene rearrangements. A recent study also shown that (S)-enantiomer crizotinib exhibits anticancer activity by targeting protein mutT homologue...
Abstract Malignant glioma is the most common brain cancer with dismal outcomes. Individual variation of patients’ survival times remarkable. Here, we investigated transcriptome and promoter methylation differences between patients malignant short (less than one year) long (more three years) in CGGA (Chinese Glioma Genome Atlas), validated TCGA (The Cancer Atlas) to identify genes whose expression levels showed high concordance prognosis patients, as well played an important role progression....
Abstract Lenvatinib, a multi-kinase inhibitor, has been approved as first-line treatment for advanced hepatocellular carcinoma (HCC), but its efficacy is limited. We have shown previously that lenvatinib and epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) combination therapy overcomes resistance in HCC with high level of EGFR expression (EGFR ). present here the results single-arm, open-label, exploratory study plus EGFR-TKI gefitinib patients to (NCT04642547; n = 30)....
Studies have showed that lead was associated with human health. However, the effects of on thyroid functions are inconsistent, and studies based Chinese population fragmentary. To evaluate correlation between different diseases, we conducted a hospital-based study. Ninety-six papillary carcinoma (PTC), 10 nodular goiter (NG), 7 adenoma (TA) patients were recruited from First Affiliated Hospital Wenzhou Medical University, China. Serum triiodothyronine (T3), free (FT3), thyroxin (FT4),...
To investigate the mRNA expression and clinical significance of structural maintenance chromosomes protein 4 (SMC4) in breast cancer. A total 23 paired samples were sequenced, data from Cancer Genome Atlas analyzed. SMC4 level was significantly upregulated cancer tissues (P < 0.001). Patients with high had poor survival = 0.012). Subgroup analyses show that nontriple negative (non-TNBC) patients, expression, older age (>65), progesterone receptor, advanced stages (III-IV) independent risk...
Objective To analyze the benefits and prognostic factors after surgical resection of pulmonary metastases from colorectal cancer (CRC). Methods From Jan. 2004 to 2015, continuous 88 cases diagnosed with CRC, including 15 synchronous 73 metachronous metastases, were analyzed in retrospective study. Results All these underwent curative 8 simultaneous surgery. The one-year, three-year five-year survival 93.4%, 60.2% 35.7%, respectively. 63 patients just have one metastasis, 25 more than...