A5058332057- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- Bone Tissue Engineering Materials
- Periodontal Regeneration and Treatments
- Wound Healing and Treatments
- Blood properties and coagulation
- Barrier Structure and Function Studies
- Electrospun Nanofibers in Biomedical Applications
- Erythrocyte Function and Pathophysiology
- Acute Ischemic Stroke Management
- Extracellular vesicles in disease
- Neurogenesis and neuroplasticity mechanisms
- Nanoparticles: synthesis and applications
- Brain Metastases and Treatment
- Human Mobility and Location-Based Analysis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Proteoglycans and glycosaminoglycans research
- Cerebrovascular and Carotid Artery Diseases
- Mesenchymal stem cell research
- Zebrafish Biomedical Research Applications
- Cell Adhesion Molecules Research
- Opportunistic and Delay-Tolerant Networks
- Titanium Alloys Microstructure and Properties
- Glioma Diagnosis and Treatment
Stomatology Hospital
2021-2024
Sun Yat-sen University
2021-2024
Renji Hospital
2019-2024
Shanghai Jiao Tong University
2019-2024
Hospital of Stomatology, Sun Yat-sen University
2023
State Key Laboratory of Oncogene and Related Genes
2021-2022
Shanghai Cancer Institute
2021-2022
Yunnan Institute of Parasitic Diseases
2018
Stroke, including ischemic stroke and hemorrhagic can cause massive neuronal death disruption of brain structure, which is followed by secondary inflammatory injury initiated pro-inflammatory molecules cellular debris. Phagocytic clearance debris microglia, the brain’s scavenger cells, pivotal for neuroinflammation resolution neurorestoration. However, microglia also exacerbate loss phagocytosing stressed-but-viable neurons in penumbra, thereby expanding area hindering neurofunctional...
Soft tissue integration is one major difficulty in the wide applications of metal materials soft tissue-related areas. The inevitable inflammatory response and subsequent fibrous reaction toward implant key for implant-soft integration. It great importance to modulate this inflammatory-fibrous response, which mainly mediated by multidirectional interaction between fibroblasts macrophages. In study, macrophages are induced generate M1 M2 macrophage immune microenvironments. Their cytokine...
The clinical efficacy of implanted biomaterials is often compromised by host immune recognition and subsequent foreign body responses (FBRs). During the implantation, inevitably come into direct contact with blood, absorbing blood protein forming clot. Many studies have been carried out to regulate adsorption, thus manipulating FBR. However, role clot surface fibrin films formed clotting shrinkage in reactions FBR ignored. Because principle film formation being relevant fibrinogen or factor...
Stroke is followed by an intricate immune interaction involving the engagement of multiple cells, including neutrophils. As one first responders recruited to brain, crucial roles neutrophils in ischemic brain damage are receiving increasing attention recent years. Notably, not homogenous, and yet there still a lack full knowledge about extent impact neutrophil heterogeneity. The biological understanding response both innate pathological conditions rapidly evolving as single-cell-RNA...
Metal materials have been widely applied clinically due to their superior mechanical properties. However, the integration of metallic implants with surrounding soft tissue remains challenging and may lead severe infections failure treatments. Development natural exemplar suggests that establishment around hard surfaces is a complex scenario associated coordination epithelial tissue, connective immune cells. In addition, influence peri-implant microenvironment on reparative process has...
Abstract Formation of blood clots, particularly the fibrin network and network‐mediated early inflammatory responses, plays a critical role in determining eventual tissue repair or regeneration following an injury. Owing to potential mediating clot‐immune it is great importance determine whether responses can be regulated via modulating parameters network. Since diameter D‐terminal fibrinogen molecule 9 nm, four different pore sizes (2, 8, 14, 20 nm) are rationally selected design mesoporous...
We collected 8700 mosquitoes in three sites China, which belonged to seven species. Their viromes were tested using metagenomic sequencing and bioinformatic analysis. The abundant viral sequences detected annotated belonging more than 50 taxonomic families. results verified by PCR, followed phylogenetic In the present study, we identified partial genes of dengue virus (DENV), a novel circovirus (CCV), densovirus (DNV), Japanese encephalitis (JEV), Wuhan mosquito (WMV) mosquitoes. Metagenomic...
Abstract Background Patients with malignancies have an increased risk of suffering ischemic stroke via several mechanisms such as coagulation dysfunction and other malignancy‐related effects well iatrogenic causes. Moreover, can be the first sign occult malignancy, termed malignancy‐associated (MAS). Therefore, timely diagnostic assessment targeted management this complex clinical situation are critical. Findings both malignancy atypical ages, factors, often exhibit symptoms multiple lesions...
Due to their good mechanical performances and high biocompatibility, all-ceramic materials are widely applied in clinics, especially orthopedic dental areas. However, the "hard" property negatively affects its integration with "soft" tissue, which greatly limits application soft tissue-related For example, implant abutments should be well integrated surrounding gingival tissue prevent invasion of bacteria. Mimicking dentine progress, we modified ion-exchange technology "activate" biological...
Metal implants holds significant promise for diverse fixed prostheses. However, their long-term reliability and broader application are hindered by challenges related to the disequilibrium at soft-hard tissue interface. By using anti-inflammatory (PDA/IL4) pro-inflammatory (PDA/LPS/IFNγ) coatings modulate distinct immune characteristics, we discovered a dynamic bioactive structure interface around metal implant, which have named 'Remodeling Triangle Area' (RTA). We further demonstrate that...
Abstract Erythrocytes are the dominant component of a blood clot in terms volume and number. However, longstanding compacted erythrocytes clots form physical barrier make fibrin mesh more anti‐fibrinolytic, thus impeding infiltration mesenchymal stem cells. The necrosis or lysis that not removed timely can also lead to release pro‐inflammatory toxic metabolites, interfering with bone regeneration. Proper bio‐elimination is essential for an undisturbed regeneration process. Here,...
Abstract Introduction Perivascular macrophages (PVMs) play pivotal roles in maintaining the physiological function of brain. Dysfunction PVMs is emerging as an important mechanism various disease conditions Methods In this work, we analyzed recent research advances PVMs, especially brain, from Web Science (WoS) core database using bibliometric analysis based on search terms “perivascular macrophages” and macrophage” October 27, 2021. Visualization collaboration were performed by Citespace...
Abstract Background The neurovascular unit (NVU) is emerging as a potential therapeutic target in neurological conditions, such stroke, brain injury, Alzheimer's disease, and Parkinson's disease; meanwhile, stroke the second leading cause of death globally. purpose study to analyze most influential articles, authors, countries, topics role NVU stroke. Methods Web Science (WoS) database was used for bibliometric analysis using search terms “Stroke” “Neurovascular unit” on January 1st, 2021....
With the advancement of Internet technology, network communication technology and mobile social applications, networks present booming development momentum. Meanwhile, due to popularity terminals such as smart phones variety PADs, it is feasible obtain relatively accurate tempo-spatial information from terminal holders. Therefore, inferring relationships among those people on basis their historical becomes one hottest research fields. In this paper, we aim infer relationship users according...
Perforating metal implants holds significant promise for diverse fixed prostheses and burgeoning human-machine interfaces. However, their long-term reliability broader application are hindered by challenges related to the imbalance at soft-hard tissue interface. Our study reveals an immune-rich anatomical region, termed 'Remodeling Triangle Area' (RTA), which is located nexus of implant interface, epithelial, connective bone highly interactive post-implantation. To further elicit RTA's...
Abstract Metal ions have regulatory activities of multi‐tissue regeneration but usually interrupt early coagulation, resulting in an abnormal hematoma structure that is not conducive to long‐term repair or regeneration. To address free metal immobilization during the coagulation phase and effectively promote ionic bioactivities through controlled macrophage uptake after ion “adjuvants” are required. [Si─O 4 ] tetrahedron has a unique coordination tetrahedral capture various adsorb plasma...