A5100699576- Advanced biosensing and bioanalysis techniques
- CRISPR and Genetic Engineering
- Fatty Acid Research and Health
- Cleft Lip and Palate Research
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- dental development and anomalies
- Biosensors and Analytical Detection
- Electrochemical Analysis and Applications
- Laser Applications in Dentistry and Medicine
- Metabolism and Genetic Disorders
- Aquaculture Nutrition and Growth
- Dental materials and restorations
- Protein Degradation and Inhibitors
- Craniofacial Disorders and Treatments
- Dental Radiography and Imaging
- Dental Erosion and Treatment
- Orthodontics and Dentofacial Orthopedics
- MicroRNA in disease regulation
- Advanced Nanomaterials in Catalysis
- Infant Nutrition and Health
- interferon and immune responses
- Peptidase Inhibition and Analysis
- Mesenchymal stem cell research
- Photoreceptor and optogenetics research
Sichuan University
2009-2025
Nanjing University
2022-2025
Affiliated Hospital of North Sichuan Medical College
2024
Shanxi Medical University
2021-2024
Fujian Agriculture and Forestry University
2024
First People's Hospital of Yunnan Province
2024
Xi'an Jiaotong University
2023
Jinan University
2023
Shaanxi Provincial People's Hospital
2023
Capital Medical University
2023
Abstract Objectives The study endeavors to undertake a bibliometric analysis on molar distalization, with the objective of illuminating its evolutionary trajectory, current status, and prognosticating future research hotspots trends. Material methods A comprehensive exploration literature distalization was carried out by conducting search in Web Science (WOS) core database University Hong Kong Electronic Library. for topic terms employed included “molar distalization,” distalisation,” “move...
Cardiovascular involvement is a rare but severe complication of Epstein-Barr virus (EBV) infections. Patients with chronic active EBV (CAEBV) are at increased risk developing cardiovascular complications and have poor prognosis. Here, we report the case pediatric patient CAEBV EBV- hemophagocytic lymphohistiocytosis (HLH) complicated giant coronary artery aneurysm (CAA) thrombosis, Valsalva sinus aneurysm, ascending aorta dilation seven years after disease onset. A previously healthy...
Sustainable and high-level new urbanization cannot be achieved without the drive of technological innovation. By collecting data from 282 prefecture-level cities in China 2007 to 2020, this paper used a two-way fixed effects model spatial Durbin analyze influence mechanisms spillover innovation on respectively. The research conclusions are as follows: (1) Technological affects positively heterogeneously due geographical location, city ranking, size. threshold test reflects that impact has...
Orthogonal therapy that combines CRISPR-based gene editing and prodrug-based chemotherapy is a promising approach to combat multidrug-resistant cancer. However, its potency precisely regulate different therapeutic modalities
Bioorthogonal conjugation reactions such as strain-promoted azide-alkyne cycloaddition (SPAAC) have become increasingly popular in recent years, they enable site-specific labeling of complex biomolecules. However, despite a number improvements to cyclooctyne design, reaction rates for SPAAC remain significantly lower than those the related copper-catalyzed (CuAAC) reaction. Here we explore micellar catalysis means increase rate between and hydrophobic azide. We find that anionic cationic...
To investigate the effect of oligodeoxynucleotides (ODNs) on differentiation rat bone marrow mesenchymal stem cells (BMSCs) to osteoblasts, in order find a candidate ODN with potential for treatment periodontitis, series ODNs were designed and selected test their promotion BMSCs osteoblasts vitro repair periodontal tissue rats periodontitis. It was found that MT01, one sequences human mitochondrial DNA, stimulated proliferation BMSCs, mRNA expression bone-associated factors including Runx2,...
The paper explored the regulatory role of oligodeoxynucleotides (ODNs) with specific sequences in proliferation and activation osteoblast, using human osteoblast-like cell line MG 63 as model. Through administration ODNs to cells at a concentration 1.0 μg/mL, ODN MT01 positive effects on osteoblast was selected from 11 different by methyl thiazolyl tetrazolium (MTT) assay alkaline phosphatase (ALP) activity measurement. To get deeper insight into molecular mechanism, treatment expression...
In modern society, the incidence of cancer, inflammatory diseases, nervous system metabolic and cardiovascular diseases is on rise. These not only cause physical mental suffering for patients, but also place an enormous burden society. Early, non-invasive diagnosis these can reduce pain patients social stress. There urgent need advanced materials methods disease marker detection, large-scale screening, early diagnosis. Biomimetic medical are synthetic designed to be biocompatible or...
CRISPR-based biosensing technology has been emerging as a revolutionary diagnostic tool for many disease-related biomarkers. In particular, RspCas13d, newly identified RNA-guided Cas13d ribonuclease derived from Ruminococcus sp., shown great promise accurate and sensitive detection of RNA due to its sequence-specific recognition robust collateral trans-cleavage activity. However, utility is limited detecting nucleic-acid-related To address this limitation, herein we present proof-of-concept...
Abstract CRISPR‐LbuCas13a has emerged as a revolutionary tool for in vitro diagnosis. Similar to other Cas effectors, LbuCas13a requires Mg 2+ maintain its nuclease activity. However, the effect of divalent metal ions on trans‐cleavage activity remains less explored. Herein, we addressed this issue by combining experimental and molecular dynamics simulation analysis. In studies showed that both Mn Ca could replace cofactors LbuCas13a. contrast, Ni , Zn Cu or Fe inhibits cis‐ trans‐ cleavage...
The aim of this analysis was to investigate the historical development, current status, and research hot spots related maxillary protraction in treatment hypoplasia.The term "TS = protraction" used search for articles Web Science Core Collection at library Capital Medical University. results were analysed using CiteSpace6.2.R1 software, including examination annual publication trends author, country, institution, keywords.A total 483 papers included study. publications showed an overall...
A CRISPR–Cas13a-powered autocatalytic cleavage circuit (CRISPR-ACC) for ultrasensitive and specific detection of a circadian clock gene was developed.
Real-time dynamic imaging of immunoactivation-related cytokines is crucial for evaluating the efficacy immune checkpoint blockade therapy and optimizing treatment regimen. We introduce herein a spatiotemporally controlled nanodevice that allows in situ photoactivated interferon-gamma (IFN-γ) secretion from T cells vitro vivo. The constructed by rational engineering an aptamer-embedded, UV-cleavable PC-DNA probe further integration with upconversion nanoparticles- CRISPR-Cas12a-enhanced...
Abstract Proteolysis‐targeting chimeras (PROTACs) have accelerated drug development; however, some challenges still exist owing to their lack of tumor selectivity and on‐demand protein degradation. Here, we developed a miR NA‐ i nitiated ssembled pre‐PRO TAC (miRiaTAC) platform that enables the activation termination target degradation in cell type‐specific manner. Using miRNA‐21 as model, engineered DNA hairpins labeled with JQ‐1 pomalidomide facilitated modular assembly DNA‐encoded...
Background: A large number of studies and clinical cases show that an ideal prognosis for mouth function cannot be obtained without sufficient reasonable postsurgical functional exercise after jaw fracture. However, no unifying criteria exist on with The study was designed to explore effective methods Materials Methods: One hundred seventeen inpatients fracture between August 2005 2006 were subjects in this study. Sequential used recover patients' gape degree, chewing, so on. Gape degree...
Abstract To investigate the microenvironment composition of gliomas and associated clinical significance, we analyzed single-cell RNA sequencing bulk RNA-seq data from glioma samples. Cell trajectory analysis identified five trajectories with distinct cell states corresponding trajectory-related genes (TRGs). TRG-based clustering segregated patients different overall survival, clinicopathological features, immune infiltration status, checkpoint gene (ICG) expression levels. Notably, a worse...