A5101776141- Healthcare and Venom Research
- Urban Transport and Accessibility
- Neuroinflammation and Neurodegeneration Mechanisms
- Liver Disease Diagnosis and Treatment
- Autopsy Techniques and Outcomes
- Pain Mechanisms and Treatments
- Hormonal and reproductive studies
- Endometriosis Research and Treatment
- Gestational Diabetes Research and Management
- Plant Pathogenic Bacteria Studies
- Atherosclerosis and Cardiovascular Diseases
- Antibiotics Pharmacokinetics and Efficacy
- Traditional Chinese Medicine Studies
- Vitamin K Research Studies
- Vitamin C and Antioxidants Research
- Inflammasome and immune disorders
- Cardiac and Coronary Surgery Techniques
- Melanoma and MAPK Pathways
- Urban Green Space and Health
- Antibiotic Resistance in Bacteria
- Ginkgo biloba and Cashew Applications
- Nicotinic Acetylcholine Receptors Study
- interferon and immune responses
- Acupuncture Treatment Research Studies
- Genomic variations and chromosomal abnormalities
Qingdao University
2011-2024
Shanghai Municipal Center For Disease Control Prevention
2022
First People's Hospital of Yunnan Province
2020
Beijing Luhe Hospital Affiliated to Capital Medical University
2016-2019
Jinhua Polytechnic
2013
Suzhou Traditional Chinese Medicine Hospital
2012
First People's Hospital of Jingzhou
2007
Melanocortin 4 receptor (MC4R) is implicated in the initiation and maintenance of neuropathic pain. Although effect MC4R on pain known, it remains unclear how mediates In vitro activates mitogen-activated kinase (MAPK). Accordingly, we investigate whether p38MAPK cascade vivo to trigger behavior Wistar rats after chronic constriction injury (CCI). Intrathecal injection antagonist HS014 (5 μg/day) at moment CCI for seven days attenuated thermal hyperalgesia mechanical allodynia. Similarly,...
Background: Neuropathic pain is characterised by spontaneous ongoing or shooting and evoked amplified responses after noxious non-noxious stimuli. develops as a result of lesions disease affecting the somatosensory nervous system either in periphery centrally. Melanocortin 4 receptor (MC4R) plays an important role initiation neuropathic but underlying mechanisms are still unclear. Methods: Adult male Wistar rats were given chronic constriction injury (CCI) sham operations. Part CCI...
Endometriosis (EMs) is one of the most common gynaecological diseases in women childbearing age. Astrocyte elevated gene-1 (AEG-1) associated with invasion, migration, apoptosis and prognosis various cancers. However, roles AEG-1 EMs its corresponding molecular mechanism are still unknown. In this study, animal models were established mice divided into two groups (n = 10): Sham group group. The cells isolated from model. gene was knocked down by shRNA, while SOCS1 siRNA. Histological...
Abstract Diabetes often induces bone loss and the dysregulation of gut microbiota (GM) is an important cause. Punicalagin (PU) was reported to regulate GM. Therefore, we hypothesized that PU could alleviate diabetes‐induced through GM their metabolites. In this study, high‐fat diet‐induced diabetic mice showed erosion poor biomechanical properties, while intake significantly improved condition mice. Further investigation revealed abundance some beneficial bacteria, such as Akkermansia...
To evaluate their prognosis, the damage by melamine on children's kidney and other organs, its influence development, was investigated.Nine hundred sixty-two Chinese children were divided into three groups: group A, 265 diagnosed with melamine-associated urolithiasis; B, 197 a history of melamine-contaminated milk powder consumption but without C, 500 healthy children. They examined at 0, 1, 3, 6 12 months. The factors influencing prognosis investigated. stone discharge monitored...
Human papillomavirus (HPV) has been identified as the primary etiological factor in cervical cancer well subsets of anogenital and oropharyngeal cancers. The two HPV viral oncoproteins, E6 E7, are uniquely consistently expressed all HPV-infected cells therefore promising targets for therapeutic vaccination. In order to achieve a synergistic antitumor anti-angiogenesis effect, we designed constructed novel DNA vaccine that can express 16 E6E7 fusion protein VEGFR2 same reading frame. A series...
Variants of the interleukin-1β (IL-1β) gene have been associated with type 2 diabetes (T2D) and coronary artery diseases (CAD). However, association IL-1β polymorphisms diabetic patients having CAD clinical manifestation has not studied yet. In this study, we aim to decipher role common promoter variants susceptibility/resistance development in T2D patients. (n = 134) or without 533) were enrolled. A total 513 essentially healthy individuals from same population included study as control....
Abstract Background The prevalence of liver complications is increasing among people living with HIV, and microbial translocation (MT) might play a vital role. We conducted prospective cohort study to evaluate the association between plasma biomarkers MT fibrosis (LF) HIV in southwest China. Method A total 665 were enrolled at baseline had least one follow‐up visit during 3‐year period. calculated Liver Fibrosis Index (FIB‐4) LF measured soluble CD14 (sCD14) lipopolysaccharide‐binding...
Objective Evaluated the feasibility, validity, and safety of mini-sternotomy off-pump coronary artery bypass grafting for triple-vessel disease. Methods One hundred sixty patients with disease were randomly assigned to undergo OPCABG or full-sternotomy. All operations performed by same surgeon, followed up from 12 16 months. Results There was no perioperative mortality conversion on-pump. The mean number grafts, new-onset atrial fibrillation statistical difference in both...